Proton magnetic resonance spectroscopy in parkinson's disease and atypical parkinsonian disorders
Identifieur interne : 008305 ( Main/Merge ); précédent : 008304; suivant : 008306Proton magnetic resonance spectroscopy in parkinson's disease and atypical parkinsonian disorders
Auteurs : Federico [Italie] ; Isabella L. Simone [Italie] ; Vincenzo Lucivero [Italie] ; Giovanni Iliceto [Italie] ; Michele De Mari [Italie] ; Paolo Giannini [Italie] ; Domenico M. Mezzapesa [Italie] ; Alfredo Tarantino [Italie] ; Paolo Lamberti [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-11.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Aspartic Acid (metabolism), Atrophy (pathology), Cerebral Cortex (pathology), Choline (metabolism), Corpus Striatum (metabolism), Creatinine (metabolism), Female, Globus Pallidus (metabolism), Globus Pallidus (pathology), Humans, Levodopa (therapeutic use), Magnetic Resonance Spectroscopy, Magnetic resonance spectroscopy, Middle Aged, Multiple system atrophy, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease, Secondary (pathology), Parkinson's disease, Phosphocreatine (metabolism), Progressive supranuclear palsy, Protons (diagnostic use), Putamen (metabolism), Putamen (pathology), Supranuclear Palsy, Progressive (pathology).
- MESH :
- chemical , diagnostic use : Protons.
- chemical , metabolism : Aspartic Acid, Choline, Creatinine, Phosphocreatine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- metabolism : Corpus Striatum, Globus Pallidus, Putamen.
- pathology : Atrophy, Cerebral Cortex, Globus Pallidus, Parkinson Disease, Parkinson Disease, Secondary, Putamen, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Magnetic Resonance Spectroscopy, Middle Aged.
Abstract
Proton magnetic resonance spectroscopy (1H‐MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple‐system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age matched controls. The study assessed the level of N‐acetylaspartate (NAA), creatine–phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H‐MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.
Url:
DOI: 10.1002/mds.870120611
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ISTEX:614049B5D1E2ED7A5E8A34DBC34A3AF860C5D7A9Le document en format XML
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Mezzapesa</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Tarantino, Alfredo" sort="Tarantino, Alfredo" uniqKey="Tarantino A" first="Alfredo" last="Tarantino">Alfredo Tarantino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-11">1997-11</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="903">903</biblScope><biblScope unit="page" to="909">909</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">614049B5D1E2ED7A5E8A34DBC34A3AF860C5D7A9</idno><idno type="DOI">10.1002/mds.870120611</idno><idno type="ArticleID">MDS870120611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Aspartic Acid (metabolism)</term><term>Atrophy (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Choline (metabolism)</term><term>Corpus Striatum (metabolism)</term><term>Creatinine (metabolism)</term><term>Female</term><term>Globus Pallidus (metabolism)</term><term>Globus Pallidus (pathology)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Spectroscopy</term><term>Magnetic resonance spectroscopy</term><term>Middle Aged</term><term>Multiple system atrophy</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease, Secondary (pathology)</term><term>Parkinson's disease</term><term>Phosphocreatine (metabolism)</term><term>Progressive supranuclear palsy</term><term>Protons (diagnostic use)</term><term>Putamen (metabolism)</term><term>Putamen (pathology)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Protons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid</term><term>Choline</term><term>Creatinine</term><term>Phosphocreatine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Globus Pallidus</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Cerebral Cortex</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term><term>Putamen</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proton magnetic resonance spectroscopy (1H‐MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple‐system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age matched controls. The study assessed the level of N‐acetylaspartate (NAA), creatine–phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H‐MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.</div></front></TEI><double doi="10.1002/mds.870120611"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proton magnetic resonance spectroscopy in parkinson's disease and atypical parkinsonian disorders</title><author><name sortKey="Federico" sort="Federico" uniqKey="Federico" last="Federico">Federico</name></author><author><name sortKey="Simone, Isabella L" sort="Simone, Isabella L" uniqKey="Simone I" first="Isabella L." last="Simone">Isabella L. Simone</name></author><author><name sortKey="Lucivero, Vincenzo" sort="Lucivero, Vincenzo" uniqKey="Lucivero V" first="Vincenzo" last="Lucivero">Vincenzo Lucivero</name></author><author><name sortKey="Iliceto, Giovanni" sort="Iliceto, Giovanni" uniqKey="Iliceto G" first="Giovanni" last="Iliceto">Giovanni Iliceto</name></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name></author><author><name sortKey="Giannini, Paolo" sort="Giannini, Paolo" uniqKey="Giannini P" first="Paolo" last="Giannini">Paolo Giannini</name></author><author><name sortKey="Mezzapesa, Domenico M" sort="Mezzapesa, Domenico M" uniqKey="Mezzapesa D" first="Domenico M." last="Mezzapesa">Domenico M. Mezzapesa</name></author><author><name sortKey="Tarantino, Alfredo" sort="Tarantino, Alfredo" uniqKey="Tarantino A" first="Alfredo" last="Tarantino">Alfredo Tarantino</name></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:614049B5D1E2ED7A5E8A34DBC34A3AF860C5D7A9</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1002/mds.870120611</idno><idno type="url">https://api.istex.fr/document/614049B5D1E2ED7A5E8A34DBC34A3AF860C5D7A9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F26</idno><idno type="wicri:Area/Istex/Curation">001F26</idno><idno type="wicri:Area/Istex/Checkpoint">003900</idno><idno type="wicri:doubleKey">0885-3185:1997:Federico:proton:magnetic:resonance</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Proton magnetic resonance spectroscopy in parkinson's disease and atypical parkinsonian disorders</title><author><name sortKey="Federico" sort="Federico" uniqKey="Federico" last="Federico">Federico</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Simone, Isabella L" sort="Simone, Isabella L" uniqKey="Simone I" first="Isabella L." last="Simone">Isabella L. Simone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Lucivero, Vincenzo" sort="Lucivero, Vincenzo" uniqKey="Lucivero V" first="Vincenzo" last="Lucivero">Vincenzo Lucivero</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Iliceto, Giovanni" sort="Iliceto, Giovanni" uniqKey="Iliceto G" first="Giovanni" last="Iliceto">Giovanni Iliceto</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Giannini, Paolo" sort="Giannini, Paolo" uniqKey="Giannini P" first="Paolo" last="Giannini">Paolo Giannini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Mezzapesa, Domenico M" sort="Mezzapesa, Domenico M" uniqKey="Mezzapesa D" first="Domenico M." last="Mezzapesa">Domenico M. Mezzapesa</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Tarantino, Alfredo" sort="Tarantino, Alfredo" uniqKey="Tarantino A" first="Alfredo" last="Tarantino">Alfredo Tarantino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-11">1997-11</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="903">903</biblScope><biblScope unit="page" to="909">909</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">614049B5D1E2ED7A5E8A34DBC34A3AF860C5D7A9</idno><idno type="DOI">10.1002/mds.870120611</idno><idno type="ArticleID">MDS870120611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Magnetic resonance spectroscopy</term><term>Multiple system atrophy</term><term>Parkinson's disease</term><term>Progressive supranuclear palsy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proton magnetic resonance spectroscopy (1H‐MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple‐system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age matched controls. The study assessed the level of N‐acetylaspartate (NAA), creatine–phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H‐MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.</title><author><name sortKey="Federico, F" sort="Federico, F" uniqKey="Federico F" first="F" last="Federico">F. Federico</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neurology and Neuroradiology, University of Bari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Simone, I L" sort="Simone, I L" uniqKey="Simone I" first="I L" last="Simone">I L Simone</name></author><author><name sortKey="Lucivero, V" sort="Lucivero, V" uniqKey="Lucivero V" first="V" last="Lucivero">V. Lucivero</name></author><author><name sortKey="Iliceto, G" sort="Iliceto, G" uniqKey="Iliceto G" first="G" last="Iliceto">G. Iliceto</name></author><author><name sortKey="De Mari, M" sort="De Mari, M" uniqKey="De Mari M" first="M" last="De Mari">M. De Mari</name></author><author><name sortKey="Giannini, P" sort="Giannini, P" uniqKey="Giannini P" first="P" last="Giannini">P. Giannini</name></author><author><name sortKey="Mezzapesa, D M" sort="Mezzapesa, D M" uniqKey="Mezzapesa D" first="D M" last="Mezzapesa">D M Mezzapesa</name></author><author><name sortKey="Tarantino, A" sort="Tarantino, A" uniqKey="Tarantino A" first="A" last="Tarantino">A. Tarantino</name></author><author><name sortKey="Lamberti, P" sort="Lamberti, P" uniqKey="Lamberti P" first="P" last="Lamberti">P. Lamberti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9399213</idno><idno type="pmid">9399213</idno><idno type="doi">10.1002/mds.870120611</idno><idno type="wicri:Area/PubMed/Corpus">004568</idno><idno type="wicri:Area/PubMed/Curation">004568</idno><idno type="wicri:Area/PubMed/Checkpoint">004592</idno><idno type="wicri:Area/Ncbi/Merge">004E17</idno><idno type="wicri:Area/Ncbi/Curation">004E17</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E17</idno><idno type="wicri:doubleKey">0885-3185:1997:Federico F:proton:magnetic:resonance</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.</title><author><name sortKey="Federico, F" sort="Federico, F" uniqKey="Federico F" first="F" last="Federico">F. Federico</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neurology and Neuroradiology, University of Bari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Clinical Neurology and Neuroradiology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Simone, I L" sort="Simone, I L" uniqKey="Simone I" first="I L" last="Simone">I L Simone</name></author><author><name sortKey="Lucivero, V" sort="Lucivero, V" uniqKey="Lucivero V" first="V" last="Lucivero">V. Lucivero</name></author><author><name sortKey="Iliceto, G" sort="Iliceto, G" uniqKey="Iliceto G" first="G" last="Iliceto">G. Iliceto</name></author><author><name sortKey="De Mari, M" sort="De Mari, M" uniqKey="De Mari M" first="M" last="De Mari">M. De Mari</name></author><author><name sortKey="Giannini, P" sort="Giannini, P" uniqKey="Giannini P" first="P" last="Giannini">P. Giannini</name></author><author><name sortKey="Mezzapesa, D M" sort="Mezzapesa, D M" uniqKey="Mezzapesa D" first="D M" last="Mezzapesa">D M Mezzapesa</name></author><author><name sortKey="Tarantino, A" sort="Tarantino, A" uniqKey="Tarantino A" first="A" last="Tarantino">A. Tarantino</name></author><author><name sortKey="Lamberti, P" sort="Lamberti, P" uniqKey="Lamberti P" first="P" last="Lamberti">P. Lamberti</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Aspartic Acid (metabolism)</term><term>Atrophy (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Choline (metabolism)</term><term>Corpus Striatum (metabolism)</term><term>Creatinine (metabolism)</term><term>Female</term><term>Globus Pallidus (metabolism)</term><term>Globus Pallidus (pathology)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Spectroscopy</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease, Secondary (pathology)</term><term>Phosphocreatine (metabolism)</term><term>Protons (diagnostic use)</term><term>Putamen (metabolism)</term><term>Putamen (pathology)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Protons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid</term><term>Choline</term><term>Creatinine</term><term>Phosphocreatine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Globus Pallidus</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Cerebral Cortex</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term><term>Putamen</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proton magnetic resonance spectroscopy (1H-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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