MovDisordV3, Main, Merge, bibRecord, 006F40

Caspase-3 activation in 1 -methyl-4-phenyl- 1, 2,3,6-tetrahydropyridine (MPTP)-treated mice

Identifieur interne : 006F40 ( Main/Merge ); précédent : 006F39; suivant : 006F41

Caspase-3 activation in 1 -methyl-4-phenyl- 1, 2,3,6-tetrahydropyridine (MPTP)-treated mice

Auteurs : Hélène Turmel [France] ; Andreas Hartmann [France] ; Karine Parain [France] ; Aicha Doubou [France] ; Anu Srinivasan [États-Unis] ; Yves Agid [France] ; Etienne C. Hirsch [France]

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0333747

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Activité enzymatique, Apoptose, Modèle animal, Pathogénie, Souris, Animal, Caspase 3.

English descriptors

KwdEn :
- Animal, Animal model, Apoptosis, Enzymatic activity, Mouse, Parkinson disease, Pathogenesis.

Abstract

In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1-methyl-4-phenylpyridinium (MPP⁺) may be mediated by caspase-3. To establish whether caspase-3 activation may indeed play a role in an in vivo model of PD, we studied caspase-3 activation in C57B1/6 mice subchronically intoxicated with MPTP. We show that caspase-3 activation peaks early, at days I and 2 after the end of MPTP intoxication. In contrast, pycnotic neurons persist until day 7 postintoxication, indicating that caspase-3 activation is an early and transient phenomenon in apoptotic death of DA neurons. We further demonstrate that loss of tyrosine hydroxylase (TH) immunoreactivity in this model is indeed due to cell loss rather than to loss of TH protein expression. We conclude that mice subchronically intoxicated with MPTP represent a valid PD model to study and manipulate caspase activation in vivo.

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Pascal:01-0333747

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>
) may be mediated by caspase-3. To establish whether caspase-3 activation may indeed play a role in an in vivo model of PD, we studied caspase-3 activation in C57B1/6 mice subchronically intoxicated with MPTP. We show that caspase-3 activation peaks early, at days I and 2 after the end of MPTP intoxication. In contrast, pycnotic neurons persist until day 7 postintoxication, indicating that caspase-3 activation is an early and transient phenomenon in apoptotic death of DA neurons. We further demonstrate that loss of tyrosine hydroxylase (TH) immunoreactivity in this model is indeed due to cell loss rather than to loss of TH protein expression. We conclude that mice subchronically intoxicated with MPTP represent a valid PD model to study and manipulate caspase activation in vivo.</div>
</front>
</TEI>
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<name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
<name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
<name sortKey="Parain, Karine" sort="Parain, Karine" uniqKey="Parain K" first="Karine" last="Parain">Karine Parain</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Srinivasan, Anu" sort="Srinivasan, Anu" uniqKey="Srinivasan A" first="Anu" last="Srinivasan">Anu Srinivasan</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Caspase-3 activation in 1 -methyl-4-phenyl- 1, 2,3,6-tetrahydropyridine (MPTP)-treated mice

Caspase-3 activation in 1 -methyl-4-phenyl- 1, 2,3,6-tetrahydropyridine (MPTP)-treated mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri