Gastric emptying time and gastric motility in patients with Parkinson's disease
Identifieur interne : 006C76 ( Main/Merge ); précédent : 006C75; suivant : 006C77Gastric emptying time and gastric motility in patients with Parkinson's disease
Auteurs : Ruth Hardoff [Israël] ; Michael Sula [Israël] ; Ada Tamir [Israël] ; Adrian Soil [Israël] ; Avi Front [Israël] ; Samich Badarna [Israël] ; Silvia Honigman [Israël] ; Nir Giladi [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-11.
English descriptors
- KwdEn :
Abstract
Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1203
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000535
- to stream Istex, to step Curation: 000535
- to stream Istex, to step Checkpoint: 003021
Links to Exploration step
ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title>
<author><name sortKey="Hardoff, Ruth" sort="Hardoff, Ruth" uniqKey="Hardoff R" first="Ruth" last="Hardoff">Ruth Hardoff</name>
</author>
<author><name sortKey="Sula, Michael" sort="Sula, Michael" uniqKey="Sula M" first="Michael" last="Sula">Michael Sula</name>
</author>
<author><name sortKey="Tamir, Ada" sort="Tamir, Ada" uniqKey="Tamir A" first="Ada" last="Tamir">Ada Tamir</name>
</author>
<author><name sortKey="Soil, Adrian" sort="Soil, Adrian" uniqKey="Soil A" first="Adrian" last="Soil">Adrian Soil</name>
</author>
<author><name sortKey="Front, Avi" sort="Front, Avi" uniqKey="Front A" first="Avi" last="Front">Avi Front</name>
</author>
<author><name sortKey="Badarna, Samich" sort="Badarna, Samich" uniqKey="Badarna S" first="Samich" last="Badarna">Samich Badarna</name>
</author>
<author><name sortKey="Honigman, Silvia" sort="Honigman, Silvia" uniqKey="Honigman S" first="Silvia" last="Honigman">Silvia Honigman</name>
</author>
<author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1203</idno>
<idno type="url">https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000535</idno>
<idno type="wicri:Area/Istex/Curation">000535</idno>
<idno type="wicri:Area/Istex/Checkpoint">003021</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Hardoff R:gastric:emptying:time</idno>
<idno type="wicri:Area/Main/Merge">006C76</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title>
<author><name sortKey="Hardoff, Ruth" sort="Hardoff, Ruth" uniqKey="Hardoff R" first="Ruth" last="Hardoff">Ruth Hardoff</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Nuclear Medicine, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sula, Michael" sort="Sula, Michael" uniqKey="Sula M" first="Michael" last="Sula">Michael Sula</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Neurology, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tamir, Ada" sort="Tamir, Ada" uniqKey="Tamir A" first="Ada" last="Tamir">Ada Tamir</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soil, Adrian" sort="Soil, Adrian" uniqKey="Soil A" first="Adrian" last="Soil">Adrian Soil</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Elgems (Elscint) Ltd., Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Front, Avi" sort="Front, Avi" uniqKey="Front A" first="Avi" last="Front">Avi Front</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Nuclear Medicine, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Badarna, Samich" sort="Badarna, Samich" uniqKey="Badarna S" first="Samich" last="Badarna">Samich Badarna</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Neurology, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Honigman, Silvia" sort="Honigman, Silvia" uniqKey="Honigman S" first="Silvia" last="Honigman">Silvia Honigman</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Neurology, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Neurology, Technion Institute of Technology, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Israël</country>
<wicri:regionArea>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv</wicri:regionArea>
<wicri:noRegion>Tel‐Aviv</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-11">2001-11</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1041">1041</biblScope>
<biblScope unit="page" to="1047">1047</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">83D5C8B08639E0394D6512B8A7B2579BD14F4F02</idno>
<idno type="DOI">10.1002/mds.1203</idno>
<idno type="ArticleID">MDS1203</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>gastric emptying</term>
<term>gastric motility</term>
<term>motor response fluctuations</term>
<term>radionuclide</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006C76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006C76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02 |texte= Gastric emptying time and gastric motility in patients with Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |