Genetic polymorphisms of superoxide dismutase in Parkinson's disease
Identifieur interne : 006C75 ( Main/Merge ); précédent : 006C74; suivant : 006C76Genetic polymorphisms of superoxide dismutase in Parkinson's disease
Auteurs : Federico M. Farin [États-Unis] ; Yolanda Hitosis [États-Unis] ; Sarah E. Hallagan [États-Unis] ; John Kushleika [États-Unis] ; James S. Woods [États-Unis] ; Patricia S. Janssen [États-Unis] ; Terri Smith-Weller [États-Unis] ; Gary M. Franklin [États-Unis] ; Phillip D. Swanson [États-Unis] ; Harvey Checkoway [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-07.
English descriptors
Abstract
Oxidative stress reactions may contribute to the pathogenesis of Parkinson's disease (PD). The superoxide dismutases potentially play significant roles in PD by detoxifying superoxide radical. We developed genomic DNA and cDNA‐based sequencing assays to identify genetic variants in the copper/zinc superoxide dismutase (SOD1) and manganese superoxide dismutase (SOD2) genes. No genetic variants were detected in the gene encoding SOD1 in DNA from 45 idiopathic PD cases and 49 controls from a population‐based case‐control study. However, we identified a previously described polymorphism of the mitochondrial targeting sequence consisting of a C47T in exon 2 of SOD2, which results in an alanine to valine substitution. We analyzed this SOD2 variant in DNA from 155 cases and 231 controls from the same study, using an allele‐specific fluorogenic 5′ nuclease assay, and found no differences in the distributions of allelic frequencies. These results indicate that SOD gene variants do not contribute to PD pathogenesis. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1153
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003212
- to stream Istex, to step Curation: 003212
- to stream Istex, to step Checkpoint: 003020
Links to Exploration step
ISTEX:4AEF194DCCFBF08819F9C42836D59A9BEAC3DDD6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic polymorphisms of superoxide dismutase in Parkinson's disease</title>
<author><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M." last="Farin">Federico M. Farin</name>
</author>
<author><name sortKey="Hitosis, Yolanda" sort="Hitosis, Yolanda" uniqKey="Hitosis Y" first="Yolanda" last="Hitosis">Yolanda Hitosis</name>
</author>
<author><name sortKey="Hallagan, Sarah E" sort="Hallagan, Sarah E" uniqKey="Hallagan S" first="Sarah E." last="Hallagan">Sarah E. Hallagan</name>
</author>
<author><name sortKey="Kushleika, John" sort="Kushleika, John" uniqKey="Kushleika J" first="John" last="Kushleika">John Kushleika</name>
</author>
<author><name sortKey="Woods, James S" sort="Woods, James S" uniqKey="Woods J" first="James S." last="Woods">James S. Woods</name>
</author>
<author><name sortKey="Janssen, Patricia S" sort="Janssen, Patricia S" uniqKey="Janssen P" first="Patricia S." last="Janssen">Patricia S. Janssen</name>
</author>
<author><name sortKey="Smith Eller, Terri" sort="Smith Eller, Terri" uniqKey="Smith Eller T" first="Terri" last="Smith-Weller">Terri Smith-Weller</name>
</author>
<author><name sortKey="Franklin, Gary M" sort="Franklin, Gary M" uniqKey="Franklin G" first="Gary M." last="Franklin">Gary M. Franklin</name>
</author>
<author><name sortKey="Swanson, Phillip D" sort="Swanson, Phillip D" uniqKey="Swanson P" first="Phillip D." last="Swanson">Phillip D. Swanson</name>
</author>
<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4AEF194DCCFBF08819F9C42836D59A9BEAC3DDD6</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1153</idno>
<idno type="url">https://api.istex.fr/document/4AEF194DCCFBF08819F9C42836D59A9BEAC3DDD6/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003212</idno>
<idno type="wicri:Area/Istex/Curation">003212</idno>
<idno type="wicri:Area/Istex/Checkpoint">003020</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Farin F:genetic:polymorphisms:of</idno>
<idno type="wicri:Area/Main/Merge">006C75</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Genetic polymorphisms of superoxide dismutase in Parkinson's disease</title>
<author><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M." last="Farin">Federico M. Farin</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Hitosis, Yolanda" sort="Hitosis, Yolanda" uniqKey="Hitosis Y" first="Yolanda" last="Hitosis">Yolanda Hitosis</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Hallagan, Sarah E" sort="Hallagan, Sarah E" uniqKey="Hallagan S" first="Sarah E." last="Hallagan">Sarah E. Hallagan</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kushleika, John" sort="Kushleika, John" uniqKey="Kushleika J" first="John" last="Kushleika">John Kushleika</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Woods, James S" sort="Woods, James S" uniqKey="Woods J" first="James S." last="Woods">James S. Woods</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Janssen, Patricia S" sort="Janssen, Patricia S" uniqKey="Janssen P" first="Patricia S." last="Janssen">Patricia S. Janssen</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Smith Eller, Terri" sort="Smith Eller, Terri" uniqKey="Smith Eller T" first="Terri" last="Smith-Weller">Terri Smith-Weller</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Franklin, Gary M" sort="Franklin, Gary M" uniqKey="Franklin G" first="Gary M." last="Franklin">Gary M. Franklin</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Swanson, Phillip D" sort="Swanson, Phillip D" uniqKey="Swanson P" first="Phillip D." last="Swanson">Phillip D. Swanson</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-07">2001-07</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="705">705</biblScope>
<biblScope unit="page" to="707">707</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">4AEF194DCCFBF08819F9C42836D59A9BEAC3DDD6</idno>
<idno type="DOI">10.1002/mds.1153</idno>
<idno type="ArticleID">MDS1153</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>genetic polymorphisms</term>
<term>oxidative stress</term>
<term>superoxide dismutase</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Oxidative stress reactions may contribute to the pathogenesis of Parkinson's disease (PD). The superoxide dismutases potentially play significant roles in PD by detoxifying superoxide radical. We developed genomic DNA and cDNA‐based sequencing assays to identify genetic variants in the copper/zinc superoxide dismutase (SOD1) and manganese superoxide dismutase (SOD2) genes. No genetic variants were detected in the gene encoding SOD1 in DNA from 45 idiopathic PD cases and 49 controls from a population‐based case‐control study. However, we identified a previously described polymorphism of the mitochondrial targeting sequence consisting of a C47T in exon 2 of SOD2, which results in an alanine to valine substitution. We analyzed this SOD2 variant in DNA from 155 cases and 231 controls from the same study, using an allele‐specific fluorogenic 5′ nuclease assay, and found no differences in the distributions of allelic frequencies. These results indicate that SOD gene variants do not contribute to PD pathogenesis. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006C75 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006C75 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:4AEF194DCCFBF08819F9C42836D59A9BEAC3DDD6 |texte= Genetic polymorphisms of superoxide dismutase in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |