MovDisordV3, Main, Merge, bibRecord, 006765

Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm

Identifieur interne : 006765 ( Main/Merge ); précédent : 006764; suivant : 006766

Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm

Auteurs : Martin Sommer [Allemagne] ; Diane Ruge [Allemagne] ; Frithjof Tergau [Allemagne] ; Wolfgang Beuche [Allemagne] ; Eckart Altenmüller [Allemagne] ; Walter Paulus [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0583929

Descripteurs français

Pascal (Inist)
- Dystonie, Main, Blépharospasme, Stimulation, Magnétique, Voie transcrânienne, Excitabilité, Cortex cérébral, Représentation, Motricité, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Blepharospasm, Cerebral cortex, Dystonia, Excitability, Exploration, Hand, Human, Magnetic, Motricity, Representation, Stimulation, Transcranial route.

Abstract

We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.

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Pascal:02-0583929

Le document en format XML

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<term>Excitabilité</term>
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<term>Motricité</term>
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<front><div type="abstract" xml:lang="en">We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm

Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri