Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
Identifieur interne : 006765 ( Main/Merge ); précédent : 006764; suivant : 006766Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm
Auteurs : Martin Sommer [Allemagne] ; Diane Ruge [Allemagne] ; Frithjof Tergau [Allemagne] ; Wolfgang Beuche [Allemagne] ; Eckart Altenmüller [Allemagne] ; Walter Paulus [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 002632
- to stream PascalFrancis, to step Curation: 000689
- to stream PascalFrancis, to step Checkpoint: 002726
Links to Exploration step
Pascal:02-0583929Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm</title>
<author><name sortKey="Sommer, Martin" sort="Sommer, Martin" uniqKey="Sommer M" first="Martin" last="Sommer">Martin Sommer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruge, Diane" sort="Ruge, Diane" uniqKey="Ruge D" first="Diane" last="Ruge">Diane Ruge</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tergau, Frithjof" sort="Tergau, Frithjof" uniqKey="Tergau F" first="Frithjof" last="Tergau">Frithjof Tergau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Music Physiology and Performing Arts Medicine, Hannover University of Music and Drama</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0583929</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0583929 INIST</idno>
<idno type="RBID">Pascal:02-0583929</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002632</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000689</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002726</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Sommer M:intracortical:excitability:in</idno>
<idno type="wicri:Area/Main/Merge">006765</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm</title>
<author><name sortKey="Sommer, Martin" sort="Sommer, Martin" uniqKey="Sommer M" first="Martin" last="Sommer">Martin Sommer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruge, Diane" sort="Ruge, Diane" uniqKey="Ruge D" first="Diane" last="Ruge">Diane Ruge</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tergau, Frithjof" sort="Tergau, Frithjof" uniqKey="Tergau F" first="Frithjof" last="Tergau">Frithjof Tergau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Music Physiology and Performing Arts Medicine, Hannover University of Music and Drama</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blepharospasm</term>
<term>Cerebral cortex</term>
<term>Dystonia</term>
<term>Excitability</term>
<term>Exploration</term>
<term>Hand</term>
<term>Human</term>
<term>Magnetic</term>
<term>Motricity</term>
<term>Representation</term>
<term>Stimulation</term>
<term>Transcranial route</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Main</term>
<term>Blépharospasme</term>
<term>Stimulation</term>
<term>Magnétique</term>
<term>Voie transcrânienne</term>
<term>Excitabilité</term>
<term>Cortex cérébral</term>
<term>Représentation</term>
<term>Motricité</term>
<term>Exploration</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Basse-Saxe</li>
</region>
<settlement><li>Göttingen</li>
<li>Hanovre</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Sommer, Martin" sort="Sommer, Martin" uniqKey="Sommer M" first="Martin" last="Sommer">Martin Sommer</name>
</region>
<name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name>
<name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name>
<name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
<name sortKey="Ruge, Diane" sort="Ruge, Diane" uniqKey="Ruge D" first="Diane" last="Ruge">Diane Ruge</name>
<name sortKey="Tergau, Frithjof" sort="Tergau, Frithjof" uniqKey="Tergau F" first="Frithjof" last="Tergau">Frithjof Tergau</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006765 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006765 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= Pascal:02-0583929 |texte= Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |