Quality of life outcomes following surgical treatment of Parkinson's disease
Identifieur interne : 006672 ( Main/Merge ); précédent : 006671; suivant : 006673Quality of life outcomes following surgical treatment of Parkinson's disease
Auteurs : Alastair Gray [Royaume-Uni] ; Lain Mcnamara [Royaume-Uni] ; Tipu Aziz [Royaume-Uni] ; Ralph Gregory [Royaume-Uni] ; Peter Bain [Royaume-Uni] ; Joanna Wilson [Royaume-Uni] ; Richard Scott [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
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- KwdEn :
Abstract
We assessed the impact of surgical treatment of Parkinson's disease on quality of life using generic quality of life instruments and utility scores. The Medical Outcomes Study short form health survey SF-36 and Parkinson's Disease Questionnaire PDQ-39 were used before and 3-6 months after surgery to assess quality of life, and the results were converted into utility valuations. Ninety-seven patients were studied; 33 underwent unilateral thalamotomy, 33 unilateral pallidotomy, 20 bilateral pallidotomy, six subthalamic nucleus (STN) lesions, four mixed lesions and in one case bilateral STN stimulation. All dimensions of the SF-36 except role mental and mental health showed statistically significant improvement following surgery. The PDQ-39 recorded significant improvements in the mobility, stigma, and bodily discomfort dimensions. The rating scale and time trade-off scales showed statistically significant gains in utility of 8% and 3%, respectively. Gains were particularly marked in the bilateral pallidotomy group. Differences in patient characteristics and selection made direct comparisons between procedures unreliable. Quality of life in patients with advanced Parkinson's disease is amenable to measurement; such measurement provides tentative evidence of significant gains in quality of life following some neurosurgical procedures.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Quality of life outcomes following surgical treatment of Parkinson's disease</title>
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<author><name sortKey="Mcnamara, Lain" sort="Mcnamara, Lain" uniqKey="Mcnamara L" first="Lain" last="Mcnamara">Lain Mcnamara</name>
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<series><title level="j" type="main">Movement disorders</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Electrical stimulus</term>
<term>Evolution</term>
<term>Exeresis</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Prognosis</term>
<term>Psychometrics</term>
<term>Quality of life</term>
<term>Subthalamic nucleus</term>
<term>Thalamus</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Qualité vie</term>
<term>Exérèse</term>
<term>Thalamus</term>
<term>Pallidum</term>
<term>Noyau sousthalamique</term>
<term>Stimulus électrique</term>
<term>Evolution</term>
<term>Traitement</term>
<term>Pronostic</term>
<term>Psychométrie</term>
<term>Adulte</term>
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<front><div type="abstract" xml:lang="en">We assessed the impact of surgical treatment of Parkinson's disease on quality of life using generic quality of life instruments and utility scores. The Medical Outcomes Study short form health survey SF-36 and Parkinson's Disease Questionnaire PDQ-39 were used before and 3-6 months after surgery to assess quality of life, and the results were converted into utility valuations. Ninety-seven patients were studied; 33 underwent unilateral thalamotomy, 33 unilateral pallidotomy, 20 bilateral pallidotomy, six subthalamic nucleus (STN) lesions, four mixed lesions and in one case bilateral STN stimulation. All dimensions of the SF-36 except role mental and mental health showed statistically significant improvement following surgery. The PDQ-39 recorded significant improvements in the mobility, stigma, and bodily discomfort dimensions. The rating scale and time trade-off scales showed statistically significant gains in utility of 8% and 3%, respectively. Gains were particularly marked in the bilateral pallidotomy group. Differences in patient characteristics and selection made direct comparisons between procedures unreliable. Quality of life in patients with advanced Parkinson's disease is amenable to measurement; such measurement provides tentative evidence of significant gains in quality of life following some neurosurgical procedures.</div>
</front>
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<orgName><li>Université d'Oxford</li>
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<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gray, Alastair" sort="Gray, Alastair" uniqKey="Gray A" first="Alastair" last="Gray">Alastair Gray</name>
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<name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name>
<name sortKey="Bain, Peter" sort="Bain, Peter" uniqKey="Bain P" first="Peter" last="Bain">Peter Bain</name>
<name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name>
<name sortKey="Mcnamara, Lain" sort="Mcnamara, Lain" uniqKey="Mcnamara L" first="Lain" last="Mcnamara">Lain Mcnamara</name>
<name sortKey="Scott, Richard" sort="Scott, Richard" uniqKey="Scott R" first="Richard" last="Scott">Richard Scott</name>
<name sortKey="Scott, Richard" sort="Scott, Richard" uniqKey="Scott R" first="Richard" last="Scott">Richard Scott</name>
<name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name>
<name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name>
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