Neurophysiological investigations in patients with primary writing tremor
Identifieur interne : 006380 ( Main/Merge ); précédent : 006379; suivant : 006381Neurophysiological investigations in patients with primary writing tremor
Auteurs : Nicola Modugno [Italie] ; Yusaku Nakamura [Italie] ; Sven Bestmann [Royaume-Uni] ; Antonio Curra [Italie] ; Alfredo Berardelli [Italie] ; John Rothwell [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-11.
English descriptors
- KwdEn :
- Aged, Cerebral Cortex (physiopathology), Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), Electromyography, Essential Tremor (diagnosis), Essential Tremor (physiopathology), Female, H-Reflex (physiology), Handwriting, Humans, Magnetics (diagnostic use), Male, Median Nerve (physiopathology), Middle Aged, Muscle, Skeletal (innervation), Neural Inhibition (physiology), Radial Nerve (physiopathology), Synaptic Transmission (physiology), Tachycardia, Paroxysmal, Tremor (diagnosis), Tremor (physiopathology), essential tremor, primary writing tremor, reciprocal inhibition, transcranial magnetic stimulation, writer's cramp.
- MESH :
- diagnosis : Dystonic Disorders, Essential Tremor, Tremor.
- diagnostic use : Magnetics.
- innervation : Muscle, Skeletal.
- physiology : H-Reflex, Neural Inhibition, Synaptic Transmission.
- physiopathology : Cerebral Cortex, Dystonic Disorders, Essential Tremor, Median Nerve, Radial Nerve, Tremor.
- Aged, Electromyography, Female, Handwriting, Humans, Male, Middle Aged, Tachycardia, Paroxysmal.
Abstract
The pathophysiology of primary writing tremor (PWT) is still unknown: it has been classified as a focal form of essential tremor and as a tremulous form of writer's cramp. We studied cortical and spinal excitability in patients with PWT and compared the results with published data of patients with essential tremor, and writer's cramp. We used electrical stimulation of median and radial nerve to study reciprocal inhibition of forearm antagonist muscles and paired transcranial magnetic stimulation at short and long interstimulus intervals (ISIs) to assess intracortical excitability. Both studies were conducted on patients with PWT and on control subjects. The early (presynaptic) and late (disynaptic) phases of reciprocal inhibition were normal as was intracortical excitability at short and long ISIs. Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10292
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<front><div type="abstract" xml:lang="en">The pathophysiology of primary writing tremor (PWT) is still unknown: it has been classified as a focal form of essential tremor and as a tremulous form of writer's cramp. We studied cortical and spinal excitability in patients with PWT and compared the results with published data of patients with essential tremor, and writer's cramp. We used electrical stimulation of median and radial nerve to study reciprocal inhibition of forearm antagonist muscles and paired transcranial magnetic stimulation at short and long interstimulus intervals (ISIs) to assess intracortical excitability. Both studies were conducted on patients with PWT and on control subjects. The early (presynaptic) and late (disynaptic) phases of reciprocal inhibition were normal as was intracortical excitability at short and long ISIs. Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor. © 2002 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The pathophysiology of primary writing tremor (PWT) is still unknown: it has been classified as a focal form of essential tremor and as a tremulous form of writer's cramp. We studied cortical and spinal excitability in patients with PWT and compared the results with published data of patients with essential tremor, and writer's cramp. We used electrical stimulation of median and radial nerve to study reciprocal inhibition of forearm antagonist muscles and paired transcranial magnetic stimulation at short and long interstimulus intervals (ISIs) to assess intracortical excitability. Both studies were conducted on patients with PWT and on control subjects. The early (presynaptic) and late (disynaptic) phases of reciprocal inhibition were normal as was intracortical excitability at short and long ISIs. Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor. © 2002 Movement Disorder Society</div>
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<author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
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<author><name sortKey="Rothwell, John" sort="Rothwell, John" uniqKey="Rothwell J" first="John" last="Rothwell">John Rothwell</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002" type="published">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Dystonic Disorders (diagnosis)</term>
<term>Dystonic Disorders (physiopathology)</term>
<term>Electromyography</term>
<term>Essential Tremor (diagnosis)</term>
<term>Essential Tremor (physiopathology)</term>
<term>Female</term>
<term>H-Reflex (physiology)</term>
<term>Handwriting</term>
<term>Humans</term>
<term>Magnetics (diagnostic use)</term>
<term>Male</term>
<term>Median Nerve (physiopathology)</term>
<term>Middle Aged</term>
<term>Muscle, Skeletal (innervation)</term>
<term>Neural Inhibition (physiology)</term>
<term>Radial Nerve (physiopathology)</term>
<term>Synaptic Transmission (physiology)</term>
<term>Tachycardia, Paroxysmal</term>
<term>Tremor (diagnosis)</term>
<term>Tremor (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonic Disorders</term>
<term>Essential Tremor</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic use" xml:lang="en"><term>Magnetics</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>H-Reflex</term>
<term>Neural Inhibition</term>
<term>Synaptic Transmission</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Dystonic Disorders</term>
<term>Essential Tremor</term>
<term>Median Nerve</term>
<term>Radial Nerve</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Electromyography</term>
<term>Female</term>
<term>Handwriting</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Tachycardia, Paroxysmal</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">The pathophysiology of primary writing tremor (PWT) is still unknown: it has been classified as a focal form of essential tremor and as a tremulous form of writer's cramp. We studied cortical and spinal excitability in patients with PWT and compared the results with published data of patients with essential tremor, and writer's cramp. We used electrical stimulation of median and radial nerve to study reciprocal inhibition of forearm antagonist muscles and paired transcranial magnetic stimulation at short and long interstimulus intervals (ISIs) to assess intracortical excitability. Both studies were conducted on patients with PWT and on control subjects. The early (presynaptic) and late (disynaptic) phases of reciprocal inhibition were normal as was intracortical excitability at short and long ISIs. Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor.</div>
</front>
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