Executive cognitive deficits in Primary dystonia
Identifieur interne : 006004 ( Main/Merge ); précédent : 006003; suivant : 006005Executive cognitive deficits in Primary dystonia
Auteurs : Richard B. Scott [Royaume-Uni] ; Ralph Gregory [Royaume-Uni] ; Joanna Wilson [Royaume-Uni] ; Sarah Banks [Royaume-Uni] ; Anna Turner [Royaume-Uni] ; Simon Parkin [Royaume-Uni] ; Nir Giladi [Israël] ; Carol Joint [Royaume-Uni] ; Tipu Aziz [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2003.
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Abstract
Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well-preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional-executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra-dimensional set-shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia.
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Scott</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Russell-Cairns Unit, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph 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aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Centre</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Joint, Carol" sort="Joint, Carol" uniqKey="Joint C" first="Carol" last="Joint">Carol Joint</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 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Scott</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Russell-Cairns Unit, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Russell-Cairns Unit, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Banks, Sarah" sort="Banks, Sarah" uniqKey="Banks S" first="Sarah" last="Banks">Sarah Banks</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Russell-Cairns Unit, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Turner, Anna" sort="Turner, Anna" uniqKey="Turner A" first="Anna" last="Turner">Anna Turner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Russell-Cairns Unit, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Parkin, Simon" sort="Parkin, Simon" uniqKey="Parkin S" first="Simon" last="Parkin">Simon Parkin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Centre</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>7 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Joint, Carol" sort="Joint, Carol" uniqKey="Joint C" first="Carol" last="Joint">Carol Joint</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Oxford Movement Disorder Group, Radcliffe Infirmary</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Dystonia</term><term>Exploration</term><term>Human</term><term>Neuropsychological test</term><term>Primary</term><term>Psychometrics</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Primaire</term><term>Trouble cognition</term><term>Test neuropsychologique</term><term>Psychométrie</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well-preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional-executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra-dimensional set-shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia.</div></front></TEI><affiliations><list><country><li>Israël</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Scott, Richard B" sort="Scott, Richard B" uniqKey="Scott R" first="Richard B." last="Scott">Richard B. Scott</name></region><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name><name sortKey="Banks, Sarah" sort="Banks, Sarah" uniqKey="Banks S" first="Sarah" last="Banks">Sarah Banks</name><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name><name sortKey="Joint, Carol" sort="Joint, Carol" uniqKey="Joint C" first="Carol" last="Joint">Carol Joint</name><name sortKey="Parkin, Simon" sort="Parkin, Simon" uniqKey="Parkin S" first="Simon" last="Parkin">Simon Parkin</name><name sortKey="Scott, Richard B" sort="Scott, Richard B" uniqKey="Scott R" first="Richard B." last="Scott">Richard B. Scott</name><name sortKey="Turner, Anna" sort="Turner, Anna" uniqKey="Turner A" first="Anna" last="Turner">Anna Turner</name><name sortKey="Turner, Anna" sort="Turner, Anna" uniqKey="Turner A" first="Anna" last="Turner">Anna Turner</name><name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name></country><country name="Israël"><noRegion><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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