MovDisordV3, Main, Merge, bibRecord, 005A23

Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT

Identifieur interne : 005A23 ( Main/Merge ); précédent : 005A22; suivant : 005A24

Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT

Auteurs : Ulrike Sommer [Allemagne] ; Thomas Hummel [Allemagne] ; Katja Cormann [Allemagne] ; Antje Mueller [Allemagne] ; Johannes Frasnelli [Allemagne] ; Joachim Kropp [Allemagne] ; Heinz Reichmann [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0581921

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Dépistage, Exploration ultrason, Parkinson maladie, Tomoscintigraphie émission monophotonique, Photon.

English descriptors

KwdEn :
- Medical screening, Nervous system diseases, Parkinson disease, Photon, Single photon emission tomography, Sonography.

Abstract

Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether "idiopathic" olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with ¹²³I-FP-CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow-up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future.

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to stream PascalFrancis, to step Curation: 000C77
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Pascal:04-0581921

Le document en format XML

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<author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
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<author><name sortKey="Frasnelli, Johannes" sort="Frasnelli, Johannes" uniqKey="Frasnelli J" first="Johannes" last="Frasnelli">Johannes Frasnelli</name>
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<author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Medical screening</term>
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<term>Sonography</term>
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<term>Dépistage</term>
<term>Exploration ultrason</term>
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<front><div type="abstract" xml:lang="en">Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether "idiopathic" olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with <sup>123</sup>
I-FP-CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow-up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Sommer, Ulrike" sort="Sommer, Ulrike" uniqKey="Sommer U" first="Ulrike" last="Sommer">Ulrike Sommer</name>
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<name sortKey="Cormann, Katja" sort="Cormann, Katja" uniqKey="Cormann K" first="Katja" last="Cormann">Katja Cormann</name>
<name sortKey="Frasnelli, Johannes" sort="Frasnelli, Johannes" uniqKey="Frasnelli J" first="Johannes" last="Frasnelli">Johannes Frasnelli</name>
<name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name>
<name sortKey="Kropp, Joachim" sort="Kropp, Joachim" uniqKey="Kropp J" first="Joachim" last="Kropp">Joachim Kropp</name>
<name sortKey="Mueller, Antje" sort="Mueller, Antje" uniqKey="Mueller A" first="Antje" last="Mueller">Antje Mueller</name>
<name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT

Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri