MovDisordV3, Main, Merge, bibRecord, 005301

In vitro models of multiple system atrophy

Identifieur interne : 005301 ( Main/Merge ); précédent : 005300; suivant : 005302

In vitro models of multiple system atrophy

Auteurs : Nadia Stefanova [Autriche] ; Markus Reindl [Autriche] ; Werner Poewe [Autriche] ; Gregor K. Wenning [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0457543

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Atrophie multisystématisée, Modèle, Inclusion.

English descriptors

KwdEn :
- Inclusion, Models, Multiple system atrophy, Nervous system diseases.

Abstract

α-Synuclein represents the major constituent of oligodendroglial cytoplasmic inclusions, the hallmark lesion of multiple system atrophy (MSA), a progressive disorder that is associated with selective degenerative cell loss in basal ganglia, cerebellum, brainstem, and spinal cord. The role of abnormal α-synuclein aggregation in oligodendroglial cells is still obscure, in particular, whether α-synuclein might impair oligodendroglial and, secondarily, neuronal integrity of those cells in the diseased brain. In an attempt to answer some of these questions, we have developed an "in vitro model of MSA" by expressing the wild-type or C-terminally truncated form of α-synuclein in glial cell cultures. With this simplified system, we have demonstrated that α-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001D72
to stream PascalFrancis, to step Curation: 000F49
to stream PascalFrancis, to step Checkpoint: 001E23

Links to Exploration step

Pascal:05-0457543

Le document en format XML

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<front><div type="abstract" xml:lang="en">α-Synuclein represents the major constituent of oligodendroglial cytoplasmic inclusions, the hallmark lesion of multiple system atrophy (MSA), a progressive disorder that is associated with selective degenerative cell loss in basal ganglia, cerebellum, brainstem, and spinal cord. The role of abnormal α-synuclein aggregation in oligodendroglial cells is still obscure, in particular, whether α-synuclein might impair oligodendroglial and, secondarily, neuronal integrity of those cells in the diseased brain. In an attempt to answer some of these questions, we have developed an "in vitro model of MSA" by expressing the wild-type or C-terminally truncated form of α-synuclein in glial cell cultures. With this simplified system, we have demonstrated that α-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

In vitro models of multiple system atrophy

In vitro models of multiple system atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri