Glutathione‐S‐transferase‐1 and interleukin‐1β gene polymorphisms in Japanese patients with Parkinson's disease
Identifieur interne : 004F91 ( Main/Merge ); précédent : 004F90; suivant : 004F92Glutathione‐S‐transferase‐1 and interleukin‐1β gene polymorphisms in Japanese patients with Parkinson's disease
Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ryuji Kaji [Japon] ; Katsuhito Yasuno [Japon] ; Hideshi Kawakami [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-07.
Descripteurs français
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Female, Genotype, Glutathione Transferase (genetics), Humans, Interleukin-1 (genetics), Japan (epidemiology), Japan (ethnology), Linkage Disequilibrium, Male, Middle Aged, Parkinson Disease (genetics), Parkinson's disease (PD), Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, RNA, Messenger (biosynthesis), Reverse Transcriptase Polymerase Chain Reaction (methods), age at onset, glutathione‐S‐transferase‐1 (GST‐1), interleukin‐1β (IL‐1β), polymorphism.
- MESH :
- chemical , biosynthesis : RNA, Messenger.
- chemical , genetics : Glutathione Transferase, Interleukin-1.
- geographic , epidemiology : Japan.
- geographic , ethnology : Japan.
- genetics : Parkinson Disease.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Female, Genotype, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length.
Abstract
We studied genetic polymorphisms in the glutathione‐S‐transferase‐1 (GST‐1) gene region and the interleukin‐1β (IL‐1β) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL‐1β genotype has affected the age at onset of PD patients, no contribution of the GST‐1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20477
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<front><div type="abstract" xml:lang="en">We studied genetic polymorphisms in the glutathione‐S‐transferase‐1 (GST‐1) gene region and the interleukin‐1β (IL‐1β) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL‐1β genotype has affected the age at onset of PD patients, no contribution of the GST‐1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons. © 2005 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">We studied genetic polymorphisms in the glutathione-S-transferase-1 (GST-1) gene region and the interleukin-1beta (IL-1beta) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL-1beta genotype has affected the age at onset of PD patients, no contribution of the GST-1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons.</div>
</front>
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