Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease.
Identifieur interne : 001229 ( Ncbi/Checkpoint ); précédent : 001228; suivant : 001230Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease.
Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno ; Ryuji Kaji ; Katsuhito Yasuno ; Hideshi KawakamiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
Descripteurs français
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Female, Genotype, Glutathione Transferase (genetics), Humans, Interleukin-1 (genetics), Japan (epidemiology), Japan (ethnology), Linkage Disequilibrium, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, RNA, Messenger (biosynthesis), Reverse Transcriptase Polymerase Chain Reaction (methods).
- MESH :
- chemical , biosynthesis : RNA, Messenger.
- chemical , genetics : Glutathione Transferase, Interleukin-1.
- geographic , epidemiology : Japan.
- geographic , ethnology : Japan.
- genetics : Parkinson Disease.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Female, Genotype, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length.
Abstract
We studied genetic polymorphisms in the glutathione-S-transferase-1 (GST-1) gene region and the interleukin-1beta (IL-1beta) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL-1beta genotype has affected the age at onset of PD patients, no contribution of the GST-1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons.
DOI: 10.1002/mds.20477
PubMed: 15834859
Affiliations:
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pubmed:15834859Le document en format XML
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uniqKey="Yasuno K" first="Katsuhito" last="Yasuno">Katsuhito Yasuno</name></author><author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20477</idno><idno type="RBID">pubmed:15834859</idno><idno type="pmid">15834859</idno><idno type="wicri:Area/PubMed/Corpus">003072</idno><idno type="wicri:Area/PubMed/Curation">003072</idno><idno type="wicri:Area/PubMed/Checkpoint">003117</idno><idno type="wicri:Area/Ncbi/Merge">001229</idno><idno type="wicri:Area/Ncbi/Curation">001229</idno><idno type="wicri:Area/Ncbi/Checkpoint">001229</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease.</title><author><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Center, Konan Hospital, Shiga, Japan. ma-nishi@vmail.plala.or.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Clinical Research Center, Konan Hospital, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name></author><author><name sortKey="Yasuno, Katsuhito" sort="Yasuno, Katsuhito" uniqKey="Yasuno K" first="Katsuhito" last="Yasuno">Katsuhito Yasuno</name></author><author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Chi-Square Distribution</term><term>Female</term><term>Genotype</term><term>Glutathione Transferase (genetics)</term><term>Humans</term><term>Interleukin-1 (genetics)</term><term>Japan (epidemiology)</term><term>Japan (ethnology)</term><term>Linkage Disequilibrium</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic</term><term>Polymorphism, Restriction Fragment Length</term><term>RNA, Messenger (biosynthesis)</term><term>Reverse Transcriptase Polymerase Chain Reaction (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutathione Transferase</term><term>Interleukin-1</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Japan</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Japan</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Chi-Square Distribution</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Polymorphism, Restriction Fragment Length</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied genetic polymorphisms in the glutathione-S-transferase-1 (GST-1) gene region and the interleukin-1beta (IL-1beta) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL-1beta genotype has affected the age at onset of PD patients, no contribution of the GST-1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name><name sortKey="Yasuno, Katsuhito" sort="Yasuno, Katsuhito" uniqKey="Yasuno K" first="Katsuhito" last="Yasuno">Katsuhito Yasuno</name></noCountry><country name="Japon"><noRegion><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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