MovDisordV3, Main, Merge, bibRecord, 004C83

Changes in motor subtype and risk for incident dementia in Parkinson's disease

Identifieur interne : 004C83 ( Main/Merge ); précédent : 004C82; suivant : 004C84

Changes in motor subtype and risk for incident dementia in Parkinson's disease

Auteurs : Guido Alves [Norvège] ; Jan Petter Larsen [Norvège] ; Murat Emre [Turquie] ; Tore Wentzel-Larsen [Norvège] ; Dag Aarsland [Norvège]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0435080

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Démence, Parkinson maladie, Trouble marche, Trouble cognition, Soustype, Facteur risque, Instabilité.

English descriptors

KwdEn :
- Cognitive disorder, Dementia, Gait disorder, Instability, Nervous system diseases, Parkinson disease, Risk factor, Subtype.

Abstract

The objective of this study was to assess the temporal relationship between changes in predominant motor symptoms and incident dementia in Parkinson's disease (PD). A community-based sample of 171 nondemented patients with PD was followed prospectively and examined at baseline and after 4 and 8 years. The motor subtype of Parkinsonism was classified into tremor-dominant (TD), indeterminate, or postural instability gait difficulty (PIGD) subtype at each visit, based on defined items in the Unified Parkinson's Disease Rating Scale, subscales II and III. Dementia was diagnosed according to DSM-III-R criteria, based on clinical interview, cognitive rating scales, and neuropsychological examination. Logistic regression was used to analyze the relationship between subtype of Parkinsonism and dementia. Transition from TD to PIGD subtype was associated with a more than threefold increase in the rate of Mini-Mental State Examination decline. Compared to patients with persistent TD or indeterminate subtype, the odds ratio for dementia was 56.7 (95% CI: 4.0- 808.4; P = 0.003) for patients changing from TD or indeterminate subtype to PIGD subtype, and 80.0 (95% CI: 4.6-1400.1; P = 0.003) for patients with persistent PIGD subtype. Patients with TD subtype at baseline did not become demented until they developed PIGD subtype, and dementia did not occur among patients with persistent TD subtype of Parkinsonism. In a substantial proportion of PD patients who develop postural instability and gait disorder during the course of the disease, this transition is associated with accelerated cognitive decline and highly increased risk for subsequent dementia. These findings raise the question whether PIGD and dementia share common or parallel neuropathology.

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Pascal:06-0435080

Le document en format XML

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<author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Norwegian Center for Movement Disorders</s1>
<s2>Stavanger</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Stavanger University Hospital</s1>
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<author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
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<author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name>
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<author><name sortKey="Wentzel Larsen, Tore" sort="Wentzel Larsen, Tore" uniqKey="Wentzel Larsen T" first="Tore" last="Wentzel-Larsen">Tore Wentzel-Larsen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Changes in motor subtype and risk for incident dementia in Parkinson's disease</title>
<author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Norwegian Center for Movement Disorders</s1>
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<author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Norwegian Center for Movement Disorders</s1>
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<author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Istanbul Faculty of Medicine, Department of Neurology, Istanbul University</s1>
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<author><name sortKey="Wentzel Larsen, Tore" sort="Wentzel Larsen, Tore" uniqKey="Wentzel Larsen T" first="Tore" last="Wentzel-Larsen">Tore Wentzel-Larsen</name>
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<author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term>
<term>Dementia</term>
<term>Gait disorder</term>
<term>Instability</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
<term>Subtype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Démence</term>
<term>Parkinson maladie</term>
<term>Trouble marche</term>
<term>Trouble cognition</term>
<term>Soustype</term>
<term>Facteur risque</term>
<term>Instabilité</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The objective of this study was to assess the temporal relationship between changes in predominant motor symptoms and incident dementia in Parkinson's disease (PD). A community-based sample of 171 nondemented patients with PD was followed prospectively and examined at baseline and after 4 and 8 years. The motor subtype of Parkinsonism was classified into tremor-dominant (TD), indeterminate, or postural instability gait difficulty (PIGD) subtype at each visit, based on defined items in the Unified Parkinson's Disease Rating Scale, subscales II and III. Dementia was diagnosed according to DSM-III-R criteria, based on clinical interview, cognitive rating scales, and neuropsychological examination. Logistic regression was used to analyze the relationship between subtype of Parkinsonism and dementia. Transition from TD to PIGD subtype was associated with a more than threefold increase in the rate of Mini-Mental State Examination decline. Compared to patients with persistent TD or indeterminate subtype, the odds ratio for dementia was 56.7 (95% CI: 4.0- 808.4; P = 0.003) for patients changing from TD or indeterminate subtype to PIGD subtype, and 80.0 (95% CI: 4.6-1400.1; P = 0.003) for patients with persistent PIGD subtype. Patients with TD subtype at baseline did not become demented until they developed PIGD subtype, and dementia did not occur among patients with persistent TD subtype of Parkinsonism. In a substantial proportion of PD patients who develop postural instability and gait disorder during the course of the disease, this transition is associated with accelerated cognitive decline and highly increased risk for subsequent dementia. These findings raise the question whether PIGD and dementia share common or parallel neuropathology.</div>
</front>
</TEI>
<affiliations><list><country><li>Norvège</li>
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</list>
<tree><country name="Norvège"><noRegion><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name>
</noRegion>
<name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
<name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
<name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name>
<name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
<name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
<name sortKey="Wentzel Larsen, Tore" sort="Wentzel Larsen, Tore" uniqKey="Wentzel Larsen T" first="Tore" last="Wentzel-Larsen">Tore Wentzel-Larsen</name>
</country>
<country name="Turquie"><noRegion><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name>
</noRegion>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Changes in motor subtype and risk for incident dementia in Parkinson's disease

Changes in motor subtype and risk for incident dementia in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri