Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Identifieur interne : 004A93 ( Main/Merge ); précédent : 004A92; suivant : 004A94Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Auteurs : Felipe Fregni [États-Unis] ; Paulo S. Boggio [Brésil] ; Marcelo C. Santos [Brésil] ; Moises Lima [Brésil] ; Adriana L. Vieira [Brésil] ; Sergio P. Rigonatti [Brésil] ; M. Teresa A. Silva [Brésil] ; Egberto R. Barbosa [Brésil] ; Michael A. Nitsche [Allemagne] ; Alvaro Pascual-Leone [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor-evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of Ml, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham-stimulation] and evaluated the effects on motor function-as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test-and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double-blinded manner. Anodal stimulation of Ml was associated with a significant improvement of motor function compared to sham-stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of Ml or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of Ml significantly increased MEP amplitude and area, cathodal stimulation of Ml significantly decreased them. There was a trend toward a significant correlation between motor function improvement after Ml anodal-tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD.
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Rigonatti</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Silva, M Teresa A" sort="Silva, M Teresa A" uniqKey="Silva M" first="M. Teresa A." last="Silva">M. Teresa A. 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Boggio</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Neuroscience Department, Mackenzie University</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Santos, Marcelo C" sort="Santos, Marcelo C" uniqKey="Santos M" first="Marcelo C." last="Santos">Marcelo C. Santos</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Lima, Moises" sort="Lima, Moises" uniqKey="Lima M" first="Moises" last="Lima">Moises Lima</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Vieira, Adriana L" sort="Vieira, Adriana L" uniqKey="Vieira A" first="Adriana L." last="Vieira">Adriana L. Vieira</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Rigonatti, Sergio P" sort="Rigonatti, Sergio P" uniqKey="Rigonatti S" first="Sergio P." last="Rigonatti">Sergio P. Rigonatti</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Silva, M Teresa A" sort="Silva, M Teresa A" uniqKey="Silva M" first="M. Teresa A." last="Silva">M. Teresa A. Silva</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Nitsche, Michael A" sort="Nitsche, Michael A" uniqKey="Nitsche M" first="Michael A." last="Nitsche">Michael A. Nitsche</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Clinical Neurophysiology, Georg August University</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Georg August University</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Direct current</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Courant continu</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor-evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of Ml, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham-stimulation] and evaluated the effects on motor function-as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test-and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double-blinded manner. Anodal stimulation of Ml was associated with a significant improvement of motor function compared to sham-stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of Ml or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of Ml significantly increased MEP amplitude and area, cathodal stimulation of Ml significantly decreased them. There was a trend toward a significant correlation between motor function improvement after Ml anodal-tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Brésil</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Fregni, Felipe" sort="Fregni, Felipe" uniqKey="Fregni F" first="Felipe" last="Fregni">Felipe Fregni</name></region><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name></region><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name><name sortKey="Lima, Moises" sort="Lima, Moises" uniqKey="Lima M" first="Moises" last="Lima">Moises Lima</name><name sortKey="Rigonatti, Sergio P" sort="Rigonatti, Sergio P" uniqKey="Rigonatti S" first="Sergio P." last="Rigonatti">Sergio P. Rigonatti</name><name sortKey="Santos, Marcelo C" sort="Santos, Marcelo C" uniqKey="Santos M" first="Marcelo C." last="Santos">Marcelo C. Santos</name><name sortKey="Silva, M Teresa A" sort="Silva, M Teresa A" uniqKey="Silva M" first="M. Teresa A." last="Silva">M. Teresa A. Silva</name><name sortKey="Vieira, Adriana L" sort="Vieira, Adriana L" uniqKey="Vieira A" first="Adriana L." last="Vieira">Adriana L. Vieira</name></country><country name="Allemagne"><noRegion><name sortKey="Nitsche, Michael A" sort="Nitsche, Michael A" uniqKey="Nitsche M" first="Michael A." last="Nitsche">Michael A. Nitsche</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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