Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Identifieur interne : 001368 ( PascalFrancis/Curation ); précédent : 001367; suivant : 001369Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Auteurs : Felipe Fregni [États-Unis] ; Paulo S. Boggio [Brésil] ; Marcelo C. Santos [Brésil] ; Moises Lima [Brésil] ; Adriana L. Vieira [Brésil] ; Sergio P. Rigonatti [Brésil] ; M. Teresa A. Silva [Brésil] ; Egberto R. Barbosa [Brésil] ; Michael A. Nitsche [Allemagne] ; Alvaro Pascual-Leone [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor-evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of Ml, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham-stimulation] and evaluated the effects on motor function-as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test-and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double-blinded manner. Anodal stimulation of Ml was associated with a significant improvement of motor function compared to sham-stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of Ml or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of Ml significantly increased MEP amplitude and area, cathodal stimulation of Ml significantly decreased them. There was a trend toward a significant correlation between motor function improvement after Ml anodal-tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD.
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Silva</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Nitsche, Michael A" sort="Nitsche, Michael A" uniqKey="Nitsche M" first="Michael A." last="Nitsche">Michael A. Nitsche</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Clinical Neurophysiology, Georg August University</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0538589</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0538589 INIST</idno><idno type="RBID">Pascal:06-0538589</idno><idno type="wicri:Area/PascalFrancis/Corpus">001953</idno><idno type="wicri:Area/PascalFrancis/Curation">001368</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease</title><author><name sortKey="Fregni, Felipe" sort="Fregni, Felipe" uniqKey="Fregni F" first="Felipe" last="Fregni">Felipe Fregni</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Neuroscience Department, Mackenzie University</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Santos, Marcelo C" sort="Santos, Marcelo C" uniqKey="Santos M" first="Marcelo C." last="Santos">Marcelo C. Santos</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Lima, Moises" sort="Lima, Moises" uniqKey="Lima M" first="Moises" last="Lima">Moises Lima</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Vieira, Adriana L" sort="Vieira, Adriana L" uniqKey="Vieira A" first="Adriana L." last="Vieira">Adriana L. Vieira</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Rigonatti, Sergio P" sort="Rigonatti, Sergio P" uniqKey="Rigonatti S" first="Sergio P." last="Rigonatti">Sergio P. Rigonatti</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Silva, M Teresa A" sort="Silva, M Teresa A" uniqKey="Silva M" first="M. Teresa A." last="Silva">M. Teresa A. Silva</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country></affiliation></author><author><name sortKey="Nitsche, Michael A" sort="Nitsche, Michael A" uniqKey="Nitsche M" first="Michael A." last="Nitsche">Michael A. Nitsche</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Clinical Neurophysiology, Georg August University</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Direct current</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Courant continu</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor-evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of Ml, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham-stimulation] and evaluated the effects on motor function-as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test-and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double-blinded manner. Anodal stimulation of Ml was associated with a significant improvement of motor function compared to sham-stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of Ml or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of Ml significantly increased MEP amplitude and area, cathodal stimulation of Ml significantly decreased them. There was a trend toward a significant correlation between motor function improvement after Ml anodal-tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>21</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>FREGNI (Felipe)</s1></fA11><fA11 i1="02" i2="1"><s1>BOGGIO (Paulo S.)</s1></fA11><fA11 i1="03" i2="1"><s1>SANTOS (Marcelo C.)</s1></fA11><fA11 i1="04" i2="1"><s1>LIMA (Moises)</s1></fA11><fA11 i1="05" i2="1"><s1>VIEIRA (Adriana L.)</s1></fA11><fA11 i1="06" i2="1"><s1>RIGONATTI (Sergio P.)</s1></fA11><fA11 i1="07" i2="1"><s1>SILVA (M. Teresa A.)</s1></fA11><fA11 i1="08" i2="1"><s1>BARBOSA (Egberto R.)</s1></fA11><fA11 i1="09" i2="1"><s1>NITSCHE (Michael A.)</s1></fA11><fA11 i1="10" i2="1"><s1>PASCUAL-LEONE (Alvaro)</s1></fA11><fA14 i1="01"><s1>Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Departments of Experimental Psychology (Institute of Psychology), Psychiatry, and Neurology, University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Neuroscience Department, Mackenzie University</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Clinical Neurophysiology, Georg August University</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>9 aut.</sZ></fA14><fA20><s1>1693-1702</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000158877800190</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>38 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0538589</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor-evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of Ml, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham-stimulation] and evaluated the effects on motor function-as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test-and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double-blinded manner. Anodal stimulation of Ml was associated with a significant improvement of motor function compared to sham-stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of Ml or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of Ml significantly increased MEP amplitude and area, cathodal stimulation of Ml significantly decreased them. There was a trend toward a significant correlation between motor function improvement after Ml anodal-tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Courant continu</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Direct current</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Corriente contínua</s0><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>353</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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