Increase in body weight after pramipexole treatment in Parkinson's disease
Identifieur interne : 004694 ( Main/Merge ); précédent : 004693; suivant : 004695Increase in body weight after pramipexole treatment in Parkinson's disease
Auteurs : Hatice Kumru [Espagne] ; Joan Santamaria [Espagne] ; Francesc Valldeoriola [Espagne] ; Maria J. Marti [Espagne] ; Eduardo Tolosa [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
English descriptors
- KwdEn :
- Affect (drug effects), Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Benzothiazoles (pharmacology), Benzothiazoles (therapeutic use), Body Mass Index, Body Weight (drug effects), Female, Follow-Up Studies, Humans, Male, Middle Aged, Movement (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson's disease, Severity of Illness Index, pramipexole, weight gain.
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Benzothiazoles.
- drug effects : Affect, Body Weight, Movement.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Antiparkinson Agents, Benzothiazoles.
- Aged, Body Mass Index, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS‐III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21086
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<front><div type="abstract" xml:lang="en">Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS‐III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS‐III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society</div>
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<term>Body Mass Index</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS-III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D(3) receptors involved in the control of feeding may be responsible for weight gain in PD.</div>
</front>
</TEI>
</PubMed>
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