Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
Identifieur interne : 004484 ( Main/Merge ); précédent : 004483; suivant : 004485Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
Auteurs : Katherine J. Schweitzer [Allemagne] ; Rüdiger Hilker [Allemagne] ; Uwe Walter [Allemagne] ; Lothar Burghaus [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-01.
English descriptors
- KwdEn :
- Adult, Aged, Disease Progression, Echoencephalography, Female, Humans, Male, Mathematical Computing, Middle Aged, Parkinson Disease (ultrasonography), Parkinson's disease, Positron-Emission Tomography, Prognosis, SN hyperechogenicity, Sensitivity and Specificity, Substantia Nigra (ultrasonography), disease progression, predisposition, transcranial sonography (TCS).
- MESH :
Abstract
Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18‐fluorodopa positron emission tomography over a follow‐up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right‐to‐left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20669
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002953
- to stream Istex, to step Curation: 002953
- to stream Istex, to step Checkpoint: 001C30
- to stream PubMed, to step Corpus: 002F02
- to stream PubMed, to step Curation: 002F02
- to stream PubMed, to step Checkpoint: 002A77
- to stream Ncbi, to step Merge: 001410
- to stream Ncbi, to step Curation: 001410
- to stream Ncbi, to step Checkpoint: 001410
Links to Exploration step
ISTEX:738D9B8A40CDE715620F856108F49C34D55105C4Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J." last="Schweitzer">Katherine J. Schweitzer</name>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:738D9B8A40CDE715620F856108F49C34D55105C4</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.20669</idno>
<idno type="url">https://api.istex.fr/document/738D9B8A40CDE715620F856108F49C34D55105C4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002953</idno>
<idno type="wicri:Area/Istex/Curation">002953</idno>
<idno type="wicri:Area/Istex/Checkpoint">001C30</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Schweitzer K:substantia:nigra:hyperechogenicity</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16114024</idno>
<idno type="wicri:Area/PubMed/Corpus">002F02</idno>
<idno type="wicri:Area/PubMed/Curation">002F02</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A77</idno>
<idno type="wicri:Area/Ncbi/Merge">001410</idno>
<idno type="wicri:Area/Ncbi/Curation">001410</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001410</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Schweitzer K:substantia:nigra:hyperechogenicity</idno>
<idno type="wicri:Area/Main/Merge">004484</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J." last="Schweitzer">Katherine J. Schweitzer</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Rostock, Rostock</wicri:regionArea>
<wicri:noRegion>Rostock</wicri:noRegion>
<wicri:noRegion>Rostock</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Genetics, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-01">2006-01</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="94">94</biblScope>
<biblScope unit="page" to="98">98</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">738D9B8A40CDE715620F856108F49C34D55105C4</idno>
<idno type="DOI">10.1002/mds.20669</idno>
<idno type="ArticleID">MDS20669</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mathematical Computing</term>
<term>Middle Aged</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Parkinson's disease</term>
<term>Positron-Emission Tomography</term>
<term>Prognosis</term>
<term>SN hyperechogenicity</term>
<term>Sensitivity and Specificity</term>
<term>Substantia Nigra (ultrasonography)</term>
<term>disease progression</term>
<term>predisposition</term>
<term>transcranial sonography (TCS)</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mathematical Computing</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prognosis</term>
<term>Sensitivity and Specificity</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18‐fluorodopa positron emission tomography over a follow‐up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right‐to‐left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD. © 2005 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.20669"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J." last="Schweitzer">Katherine J. Schweitzer</name>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:738D9B8A40CDE715620F856108F49C34D55105C4</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.20669</idno>
<idno type="url">https://api.istex.fr/document/738D9B8A40CDE715620F856108F49C34D55105C4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002953</idno>
<idno type="wicri:Area/Istex/Curation">002953</idno>
<idno type="wicri:Area/Istex/Checkpoint">001C30</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Schweitzer K:substantia:nigra:hyperechogenicity</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J." last="Schweitzer">Katherine J. Schweitzer</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Rostock, Rostock</wicri:regionArea>
<wicri:noRegion>Rostock</wicri:noRegion>
<wicri:noRegion>Rostock</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Genetics, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-01">2006-01</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="94">94</biblScope>
<biblScope unit="page" to="98">98</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">738D9B8A40CDE715620F856108F49C34D55105C4</idno>
<idno type="DOI">10.1002/mds.20669</idno>
<idno type="ArticleID">MDS20669</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>SN hyperechogenicity</term>
<term>disease progression</term>
<term>predisposition</term>
<term>transcranial sonography (TCS)</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18‐fluorodopa positron emission tomography over a follow‐up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right‐to‐left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD. © 2005 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J" last="Schweitzer">Katherine J. Schweitzer</name>
<affiliation wicri:level="1"><nlm:affiliation>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="doi">10.1002/mds.20669</idno>
<idno type="RBID">pubmed:16114024</idno>
<idno type="pmid">16114024</idno>
<idno type="wicri:Area/PubMed/Corpus">002F02</idno>
<idno type="wicri:Area/PubMed/Curation">002F02</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A77</idno>
<idno type="wicri:Area/Ncbi/Merge">001410</idno>
<idno type="wicri:Area/Ncbi/Curation">001410</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001410</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Schweitzer K:substantia:nigra:hyperechogenicity</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.</title>
<author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J" last="Schweitzer">Katherine J. Schweitzer</name>
<affiliation wicri:level="1"><nlm:affiliation>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
</author>
<author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name>
</author>
<author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name>
</author>
<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mathematical Computing</term>
<term>Middle Aged</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Positron-Emission Tomography</term>
<term>Prognosis</term>
<term>Sensitivity and Specificity</term>
<term>Substantia Nigra (ultrasonography)</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Echoencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mathematical Computing</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prognosis</term>
<term>Sensitivity and Specificity</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7+/-26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004484 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004484 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:738D9B8A40CDE715620F856108F49C34D55105C4 |texte= Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |