Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.
Identifieur interne : 001410 ( Ncbi/Curation ); précédent : 001409; suivant : 001411Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.
Auteurs : Katherine J. Schweitzer [Allemagne] ; Rüdiger Hilker ; Uwe Walter ; Lothar Burghaus ; Daniela BergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
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Abstract
Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7+/-26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.
DOI: 10.1002/mds.20669
PubMed: 16114024
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Schweitzer</name><affiliation wicri:level="1"><nlm:affiliation>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name></author><author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20669</idno><idno type="RBID">pubmed:16114024</idno><idno type="pmid">16114024</idno><idno type="wicri:Area/PubMed/Corpus">002F02</idno><idno type="wicri:Area/PubMed/Curation">002F02</idno><idno type="wicri:Area/PubMed/Checkpoint">002A77</idno><idno type="wicri:Area/Ncbi/Merge">001410</idno><idno type="wicri:Area/Ncbi/Curation">001410</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease.</title><author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J" last="Schweitzer">Katherine J. Schweitzer</name><affiliation wicri:level="1"><nlm:affiliation>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute of Clinical Brain Research, University of Tübingen, Tübingen, and Department of Neurology, University Hospital, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name></author><author><name sortKey="Burghaus, Lothar" sort="Burghaus, Lothar" uniqKey="Burghaus L" first="Lothar" last="Burghaus">Lothar Burghaus</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Echoencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Mathematical Computing</term><term>Middle Aged</term><term>Parkinson Disease (ultrasonography)</term><term>Positron-Emission Tomography</term><term>Prognosis</term><term>Sensitivity and Specificity</term><term>Substantia Nigra (ultrasonography)</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Echoencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Mathematical Computing</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Prognosis</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7+/-26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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