GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
Identifieur interne : 004254 ( Main/Merge ); précédent : 004253; suivant : 004255GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
Auteurs : John C. Mchugh [Irlande (pays)] ; Brian Murray [Irlande (pays)] ; Radhakrishnan Renganathan [Irlande (pays)] ; Sean Connolly [Irlande (pays)] ; Tim Lynch [Irlande (pays)]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
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Abstract
Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.
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Mchugh</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neurophysiology, St Vincent's University Hospital, Elm Park</s1><s2>Dublin</s2><s3>IRL</s3><sZ>4 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0391090</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0391090 INIST</idno><idno type="RBID">Pascal:07-0391090</idno><idno type="wicri:Area/PascalFrancis/Corpus">001606</idno><idno type="wicri:Area/PascalFrancis/Curation">001715</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001664</idno><idno type="wicri:doubleKey">0885-3185:2007:Mchugh J:gad:antibody:positive</idno><idno type="wicri:Area/Main/Merge">004254</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma</title><author><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C." last="Mchugh">John C. Mchugh</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neurophysiology, St Vincent's University Hospital, Elm Park</s1><s2>Dublin</s2><s3>IRL</s3><sZ>4 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Mater Misericordiae University Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinoma</term><term>Grawitz tumor</term><term>Nervous system diseases</term><term>Paraneoplastic syndrome</term><term>Stiff man syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Paranéoplasique syndrome</term><term>Homme raide syndrome</term><term>Hypernéphrome</term><term>Carcinome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti-GAD positive PSPS in a 53-year-old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C." last="Mchugh">John C. Mchugh</name></noRegion><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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