Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease
Identifieur interne : 004211 ( Main/Merge ); précédent : 004210; suivant : 004212Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease
Auteurs : Lindsy N. Williams [États-Unis] ; Paul Seignourel [États-Unis] ; Gregory P. Crucian [États-Unis] ; Michael S. Okun [États-Unis] ; Ramon L. Rodriguez [États-Unis] ; Frank M. Skidmore [États-Unis] ; Paul S. Foster [États-Unis] ; Charles E. Iv Jacobson [États-Unis] ; Janet Romrell [États-Unis] ; Dawn Bowers [États-Unis] ; Hubert H. Fernandez [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = -0.57, t(104) # -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized β # -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β= -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized β= - 0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized β= - 0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β= - 0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function.
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Williams</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Seignourel, Paul" sort="Seignourel, Paul" uniqKey="Seignourel P" first="Paul" last="Seignourel">Paul Seignourel</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Clinical and Health Psychology, University of Florida</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Crucian, Gregory P" sort="Crucian, Gregory P" uniqKey="Crucian G" first="Gregory P." last="Crucian">Gregory P. 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Foster</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Jacobson, Charles E Iv" sort="Jacobson, Charles E Iv" uniqKey="Jacobson C" first="Charles E. Iv" last="Jacobson">Charles E. Iv Jacobson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Romrell, Janet" sort="Romrell, Janet" uniqKey="Romrell J" first="Janet" last="Romrell">Janet Romrell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Clinical and Health Psychology, University of Florida</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. 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Williams</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Seignourel, Paul" sort="Seignourel, Paul" uniqKey="Seignourel P" first="Paul" last="Seignourel">Paul Seignourel</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Clinical and Health Psychology, University of Florida</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Crucian, Gregory P" sort="Crucian, Gregory P" uniqKey="Crucian G" first="Gregory P." last="Crucian">Gregory P. Crucian</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Skidmore, Frank M" sort="Skidmore, Frank M" uniqKey="Skidmore F" first="Frank M." last="Skidmore">Frank M. Skidmore</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Foster, Paul S" sort="Foster, Paul S" uniqKey="Foster P" first="Paul S." last="Foster">Paul S. Foster</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Jacobson, Charles E Iv" sort="Jacobson, Charles E Iv" uniqKey="Jacobson C" first="Charles E. Iv" last="Jacobson">Charles E. Iv Jacobson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Romrell, Janet" sort="Romrell, Janet" uniqKey="Romrell J" first="Janet" last="Romrell">Janet Romrell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Clinical and Health Psychology, University of Florida</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1><s2>Gainesville, Florida</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term><term>Cognitive disorder</term><term>Dementia</term><term>Instability</term><term>Laterality</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Trouble cognition</term><term>Parkinson maladie</term><term>Démence</term><term>Latéralité</term><term>Cognition</term><term>Instabilité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = -0.57, t(104) # -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized β # -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β= -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized β= - 0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized β= - 0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β= - 0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Williams, Lindsy N" sort="Williams, Lindsy N" uniqKey="Williams L" first="Lindsy N." last="Williams">Lindsy N. Williams</name></region><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Crucian, Gregory P" sort="Crucian, Gregory P" uniqKey="Crucian G" first="Gregory P." last="Crucian">Gregory P. Crucian</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><name sortKey="Foster, Paul S" sort="Foster, Paul S" uniqKey="Foster P" first="Paul S." last="Foster">Paul S. Foster</name><name sortKey="Jacobson, Charles E Iv" sort="Jacobson, Charles E Iv" uniqKey="Jacobson C" first="Charles E. Iv" last="Jacobson">Charles E. Iv Jacobson</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name><name sortKey="Romrell, Janet" sort="Romrell, Janet" uniqKey="Romrell J" first="Janet" last="Romrell">Janet Romrell</name><name sortKey="Seignourel, Paul" sort="Seignourel, Paul" uniqKey="Seignourel P" first="Paul" last="Seignourel">Paul Seignourel</name><name sortKey="Skidmore, Frank M" sort="Skidmore, Frank M" uniqKey="Skidmore F" first="Frank M." last="Skidmore">Frank M. 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