MovDisordV3, PascalFrancis, Curation, bibRecord, 001503

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Identifieur interne : 001503 ( PascalFrancis/Curation ); précédent : 001502; suivant : 001504

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Auteurs : Lindsy N. Williams [États-Unis] ; Paul Seignourel [États-Unis] ; Gregory P. Crucian [États-Unis] ; Michael S. Okun [États-Unis] ; Ramon L. Rodriguez [États-Unis] ; Frank M. Skidmore [États-Unis] ; Paul S. Foster [États-Unis] ; Charles E. Iv Jacobson [États-Unis] ; Janet Romrell [États-Unis] ; Dawn Bowers [États-Unis] ; Hubert H. Fernandez [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0133234

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Trouble cognition, Parkinson maladie, Démence, Latéralité, Cognition, Instabilité.

English descriptors

KwdEn :
- Cognition, Cognitive disorder, Dementia, Instability, Laterality, Nervous system diseases, Parkinson disease.

Abstract

We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = -0.57, t(104) # -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized β # -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β= -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized β= - 0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized β= - 0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β= - 0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function.

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A08	`01`	`1`	`ENG`	`@1 Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease`
A11	`01`	`1`		`@1 WILLIAMS (Lindsy N.)`
A11	`02`	`1`		`@1 SEIGNOUREL (Paul)`
A11	`03`	`1`		`@1 CRUCIAN (Gregory P.)`
A11	`04`	`1`		`@1 OKUN (Michael S.)`
A11	`05`	`1`		`@1 RODRIGUEZ (Ramon L.)`
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C01	`01`		`ENG`	@0 We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = -0.57, t(104) # -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized β # -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β= -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized β= - 0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized β= - 0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β= - 0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function.
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease</title>
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<author><name sortKey="Jacobson, Charles E Iv" sort="Jacobson, Charles E Iv" uniqKey="Jacobson C" first="Charles E. Iv" last="Jacobson">Charles E. Iv Jacobson</name>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Florida College of Medicine</s1>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Nervous system diseases</term>
<term>Parkinson disease</term>
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<front><div type="abstract" xml:lang="en">We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = -0.57, t(104) # -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized β # -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β= -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized β= - 0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized β= - 0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β= - 0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease

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