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Manganic encephalopathy due to "ephedrone" abuse

Identifieur interne : 004186 ( Main/Merge ); précédent : 004185; suivant : 004187

Manganic encephalopathy due to "ephedrone" abuse

Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk [Ukraine] ; Lyudmyla Fedoryshyn [Ukraine] ; Iryna Komnatska [Ukraine] ; Yuriy Matviyenko [Ukraine] ; Stanley Fahn [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0391089

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Encéphalopathie, Parkinsonisme, Toxicomanie, Abus, Manganèse, Intoxication.
Wicri :
- topic : Toxicomanie, Manganèse.

English descriptors

KwdEn :
- Abuse, Drug addiction, Encephalopathy, Manganese, Nervous system diseases, Parkinsonism, Poisoning.

Abstract

We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.

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Pascal:07-0391089

Le document en format XML

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<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
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<s2>Lviv</s2>
<s3>UKR</s3>
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<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Manganic encephalopathy due to "ephedrone" abuse</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
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<wicri:noRegion>Lviv</wicri:noRegion>
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<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University</s1>
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<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
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<sZ>3 aut.</sZ>
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<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of MRI, Central Hospital of the Lviv Regional Railway</s1>
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<s3>UKR</s3>
<sZ>4 aut.</sZ>
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<wicri:noRegion>Lviv</wicri:noRegion>
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<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
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<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>5 aut.</sZ>
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<wicri:noRegion>Lviv</wicri:noRegion>
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<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Columbia University Medical Center</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abuse</term>
<term>Drug addiction</term>
<term>Encephalopathy</term>
<term>Manganese</term>
<term>Nervous system diseases</term>
<term>Parkinsonism</term>
<term>Poisoning</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Encéphalopathie</term>
<term>Parkinsonisme</term>
<term>Toxicomanie</term>
<term>Abus</term>
<term>Manganèse</term>
<term>Intoxication</term>
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<front><div type="abstract" xml:lang="en">We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</div>
</front>
</TEI>
<affiliations><list><country><li>Ukraine</li>
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<tree><country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
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<name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
<name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
<name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
<name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
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<country name="États-Unis"><region name="État de New York"><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Manganic encephalopathy due to "ephedrone" abuse

Manganic encephalopathy due to "ephedrone" abuse

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri