Manganic encephalopathy due to "ephedrone" abuse
Identifieur interne : 004186 ( Main/Merge ); précédent : 004185; suivant : 004187Manganic encephalopathy due to "ephedrone" abuse
Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk [Ukraine] ; Lyudmyla Fedoryshyn [Ukraine] ; Iryna Komnatska [Ukraine] ; Yuriy Matviyenko [Ukraine] ; Stanley Fahn [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Toxicomanie, Manganèse.
English descriptors
- KwdEn :
Abstract
We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001607
- to stream PascalFrancis, to step Curation: 001714
- to stream PascalFrancis, to step Checkpoint: 001596
Links to Exploration step
Pascal:07-0391089Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Manganic encephalopathy due to "ephedrone" abuse</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Lviv Regional Clinical Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Lviv Regional Clinical Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of MRI, Central Hospital of the Lviv Regional Railway</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Danylo Halytsky Lviv National Medical University</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Columbia University Medical Center</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0391089</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0391089 INIST</idno>
<idno type="RBID">Pascal:07-0391089</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001607</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001714</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001596</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Sanotsky Y:manganic:encephalopathy:due</idno>
<idno type="wicri:Area/Main/Merge">004186</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Manganic encephalopathy due to "ephedrone" abuse</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Lviv Regional Clinical Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Lviv Regional Clinical Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of MRI, Central Hospital of the Lviv Regional Railway</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Danylo Halytsky Lviv National Medical University</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Columbia University Medical Center</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abuse</term>
<term>Drug addiction</term>
<term>Encephalopathy</term>
<term>Manganese</term>
<term>Nervous system diseases</term>
<term>Parkinsonism</term>
<term>Poisoning</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Encéphalopathie</term>
<term>Parkinsonisme</term>
<term>Toxicomanie</term>
<term>Abus</term>
<term>Manganèse</term>
<term>Intoxication</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Toxicomanie</term>
<term>Manganèse</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</div>
</front>
</TEI>
<affiliations><list><country><li>Ukraine</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
</noRegion>
<name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
<name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
<name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
<name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004186 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004186 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= Pascal:07-0391089 |texte= Manganic encephalopathy due to "ephedrone" abuse }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |