MovDisordV3, Main, Merge, bibRecord, 004133

Pathophysiological concepts of restless legs syndrome

Identifieur interne : 004133 ( Main/Merge ); précédent : 004132; suivant : 004134

Pathophysiological concepts of restless legs syndrome

Auteurs : Walter Paulus [Allemagne] ; Pascal Dowling [Allemagne] ; Roselyne Rijsman [Pays-Bas] ; Karin Stiasny-Kolster [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Al De Weerd [Pays-Bas]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393266

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Impatience membre inférieur syndrome, Physiopathologie, Dopamine, Opiacés.

English descriptors

KwdEn :
- Dopamine, Nervous system diseases, Opiates, Pathophysiology, Restless legs syndrome.

Abstract

Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing.

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Pascal:07-0393266

Le document en format XML

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<author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
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<country>Allemagne</country>
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<wicri:noRegion>University of Gottingen</wicri:noRegion>
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<author><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name>
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<author><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name>
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<author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pathophysiological concepts of restless legs syndrome</title>
<author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Gottingen</s1>
<s2>Gottingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>Allemagne</country>
<wicri:noRegion>Gottingen</wicri:noRegion>
<wicri:noRegion>University of Gottingen</wicri:noRegion>
<wicri:noRegion>Gottingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Gottingen</s1>
<s2>Gottingen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Gottingen</wicri:noRegion>
<wicri:noRegion>University of Gottingen</wicri:noRegion>
<wicri:noRegion>Gottingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neurophysiology and Sleepcenter. MCHaaglanden, Westeinde Hospital</s1>
<s2>The Hague</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>The Hague</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
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<s3>DEU</s3>
<sZ>4 aut.</sZ>
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<wicri:noRegion>Department of Neurology, Philipps University of Marburg</wicri:noRegion>
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</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
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<s3>DEU</s3>
<sZ>5 aut.</sZ>
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<author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Sleepcenter and Department of Clinical Neurophysiology, SEIN Zwolle</s1>
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<s3>NLD</s3>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term>
<term>Nervous system diseases</term>
<term>Opiates</term>
<term>Pathophysiology</term>
<term>Restless legs syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Impatience membre inférieur syndrome</term>
<term>Physiopathologie</term>
<term>Dopamine</term>
<term>Opiacés</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Pays-Bas</li>
</country>
<region><li>District de Kassel</li>
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<settlement><li>Cassel (Hesse)</li>
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<tree><country name="Allemagne"><noRegion><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name>
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<name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name>
<name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
<name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name>
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<name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name>
</country>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Pathophysiological concepts of restless legs syndrome

Pathophysiological concepts of restless legs syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri