Pathophysiological concepts of restless legs syndrome
Identifieur interne : 001543 ( PascalFrancis/Checkpoint ); précédent : 001542; suivant : 001544Pathophysiological concepts of restless legs syndrome
Auteurs : Walter Paulus [Allemagne] ; Pascal Dowling [Allemagne] ; Roselyne Rijsman [Pays-Bas] ; Karin Stiasny-Kolster [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Al De Weerd [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing.
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MCHaaglanden, Westeinde Hospital</s1><s2>The Hague</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Philipps University of Marburg</s1><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Philipps University of Marburg</wicri:noRegion><wicri:noRegion>Department of Neurology, Philipps University of Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Paracelsus Elena Klinik, Centre of Parkinsonism and Movement Disorders</s1><s2>Kassel</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Sleepcenter and Department of Clinical Neurophysiology, SEIN Zwolle</s1><s2>Zwolle</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Zwolle</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0393266</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0393266 INIST</idno><idno type="RBID">Pascal:07-0393266</idno><idno type="wicri:Area/PascalFrancis/Corpus">001590</idno><idno type="wicri:Area/PascalFrancis/Curation">001731</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001543</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pathophysiological concepts of restless legs syndrome</title><author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Gottingen</s1><s2>Gottingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Gottingen</wicri:noRegion><wicri:noRegion>University of Gottingen</wicri:noRegion><wicri:noRegion>Gottingen</wicri:noRegion></affiliation></author><author><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neurophysiology, University of Gottingen</s1><s2>Gottingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Gottingen</wicri:noRegion><wicri:noRegion>University of Gottingen</wicri:noRegion><wicri:noRegion>Gottingen</wicri:noRegion></affiliation></author><author><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neurophysiology and Sleepcenter. MCHaaglanden, Westeinde Hospital</s1><s2>The Hague</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Philipps University of Marburg</s1><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Philipps University of Marburg</wicri:noRegion><wicri:noRegion>Department of Neurology, Philipps University of Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Paracelsus Elena Klinik, Centre of Parkinsonism and Movement Disorders</s1><s2>Kassel</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Sleepcenter and Department of Clinical Neurophysiology, SEIN Zwolle</s1><s2>Zwolle</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Zwolle</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term><term>Nervous system diseases</term><term>Opiates</term><term>Pathophysiology</term><term>Restless legs syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Impatience membre inférieur syndrome</term><term>Physiopathologie</term><term>Dopamine</term><term>Opiacés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. 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