Augmentation of restless legs syndrome with long‐term tramadol treatment
Identifieur interne : 003F24 ( Main/Merge ); précédent : 003F23; suivant : 003F25Augmentation of restless legs syndrome with long‐term tramadol treatment
Auteurs : Roberto Vetrugno [Italie] ; Chiara La Morgia [Italie] ; Roberto D'Angelo [Italie] ; Daniela Loi [Italie] ; Federica Provini [Italie] ; Giuseppe Plazzi [Italie] ; Pasquale Montagna [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
English descriptors
- KwdEn :
- Aged, 80 and over, Analgesics, Opioid (adverse effects), Drug Synergism, Electroencephalography, Female, Follow-Up Studies, Humans, Paresthesia (drug therapy), Polysomnography, Restless Legs Syndrome (chemically induced), Tramadol (adverse effects), augmentation, opioids, polysomnography, restless legs syndrome, tramadol.
- MESH :
- chemical , adverse effects : Analgesics, Opioid, Tramadol.
- chemically induced : Restless Legs Syndrome.
- drug therapy : Paresthesia.
- Aged, 80 and over, Drug Synergism, Electroencephalography, Female, Follow-Up Studies, Humans, Polysomnography.
Abstract
Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21342
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<term>Tramadol (adverse effects)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Analgesics, Opioid</term>
<term>Tramadol</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Paresthesia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term>
<term>Drug Synergism</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Polysomnography</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long-term treatment with tramadol, an opioid agonist with selectivity for mu-receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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