Augmentation of restless legs syndrome with long‐term tramadol treatment
Identifieur interne : 003F24 ( Main/Merge ); précédent : 003F23; suivant : 003F25Augmentation of restless legs syndrome with long‐term tramadol treatment
Auteurs : Roberto Vetrugno [Italie] ; Chiara La Morgia [Italie] ; Roberto D'Angelo [Italie] ; Daniela Loi [Italie] ; Federica Provini [Italie] ; Giuseppe Plazzi [Italie] ; Pasquale Montagna [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
English descriptors
- KwdEn :
- Aged, 80 and over, Analgesics, Opioid (adverse effects), Drug Synergism, Electroencephalography, Female, Follow-Up Studies, Humans, Paresthesia (drug therapy), Polysomnography, Restless Legs Syndrome (chemically induced), Tramadol (adverse effects), augmentation, opioids, polysomnography, restless legs syndrome, tramadol.
- MESH :
- chemical , adverse effects : Analgesics, Opioid, Tramadol.
- chemically induced : Restless Legs Syndrome.
- drug therapy : Paresthesia.
- Aged, 80 and over, Drug Synergism, Electroencephalography, Female, Follow-Up Studies, Humans, Polysomnography.
Abstract
Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21342
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wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-02-15">2007-02-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="424">424</biblScope><biblScope unit="page" to="427">427</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3D616CF951A1997078440AFD5E902424EC03724A</idno><idno type="DOI">10.1002/mds.21342</idno><idno type="ArticleID">MDS21342</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Analgesics, Opioid (adverse effects)</term><term>Drug Synergism</term><term>Electroencephalography</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Paresthesia (drug therapy)</term><term>Polysomnography</term><term>Restless Legs Syndrome (chemically induced)</term><term>Tramadol (adverse effects)</term><term>augmentation</term><term>opioids</term><term>polysomnography</term><term>restless legs syndrome</term><term>tramadol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Analgesics, Opioid</term><term>Tramadol</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Paresthesia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Drug Synergism</term><term>Electroencephalography</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Polysomnography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.21342"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Augmentation of restless legs syndrome with long‐term tramadol treatment</title><author><name sortKey="Vetrugno, Roberto" sort="Vetrugno, Roberto" uniqKey="Vetrugno R" first="Roberto" last="Vetrugno">Roberto Vetrugno</name></author><author><name sortKey="La Morgia, Chiara" sort="La Morgia, Chiara" uniqKey="La Morgia C" first="Chiara" last="La Morgia">Chiara La Morgia</name></author><author><name sortKey="D Angelo, Roberto" sort="D Angelo, Roberto" uniqKey="D Angelo R" first="Roberto" last="D'Angelo">Roberto D'Angelo</name></author><author><name sortKey="Loi, Daniela" sort="Loi, Daniela" uniqKey="Loi D" first="Daniela" 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level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-02-15">2007-02-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="424">424</biblScope><biblScope unit="page" to="427">427</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3D616CF951A1997078440AFD5E902424EC03724A</idno><idno type="DOI">10.1002/mds.21342</idno><idno type="ArticleID">MDS21342</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>augmentation</term><term>opioids</term><term>polysomnography</term><term>restless legs syndrome</term><term>tramadol</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Augmentation of restless legs syndrome with long-term tramadol treatment.</title><author><name sortKey="Vetrugno, Roberto" sort="Vetrugno, Roberto" uniqKey="Vetrugno R" first="Roberto" last="Vetrugno">Roberto Vetrugno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy. vetrugno@neuro.unibo.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="La Morgia, Chiara" sort="La Morgia, Chiara" uniqKey="La Morgia C" first="Chiara" last="La Morgia">Chiara La Morgia</name></author><author><name sortKey="D Angelo, Roberto" sort="D Angelo, Roberto" uniqKey="D Angelo R" first="Roberto" last="D'Angelo">Roberto D'Angelo</name></author><author><name sortKey="Loi, Daniela" sort="Loi, Daniela" uniqKey="Loi D" first="Daniela" last="Loi">Daniela Loi</name></author><author><name sortKey="Provini, Federica" sort="Provini, Federica" uniqKey="Provini F" first="Federica" last="Provini">Federica Provini</name></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21342</idno><idno type="RBID">pubmed:17230457</idno><idno 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Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="La Morgia, Chiara" sort="La Morgia, Chiara" uniqKey="La Morgia C" first="Chiara" last="La Morgia">Chiara La Morgia</name></author><author><name sortKey="D Angelo, Roberto" sort="D Angelo, Roberto" uniqKey="D Angelo R" first="Roberto" last="D'Angelo">Roberto D'Angelo</name></author><author><name sortKey="Loi, Daniela" sort="Loi, Daniela" uniqKey="Loi D" first="Daniela" last="Loi">Daniela Loi</name></author><author><name sortKey="Provini, Federica" sort="Provini, Federica" uniqKey="Provini F" first="Federica" last="Provini">Federica Provini</name></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Analgesics, Opioid (adverse effects)</term><term>Drug Synergism</term><term>Electroencephalography</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Paresthesia (drug therapy)</term><term>Polysomnography</term><term>Restless Legs Syndrome (chemically induced)</term><term>Tramadol (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Analgesics, Opioid</term><term>Tramadol</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Paresthesia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Drug Synergism</term><term>Electroencephalography</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Polysomnography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long-term treatment with tramadol, an opioid agonist with selectivity for mu-receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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