Augmentation of restless legs syndrome with long‐term tramadol treatment
Identifieur interne : 002D58 ( Istex/Corpus ); précédent : 002D57; suivant : 002D59Augmentation of restless legs syndrome with long‐term tramadol treatment
Auteurs : Roberto Vetrugno ; Chiara La Morgia ; Roberto D'Angelo ; Daniela Loi ; Federica Provini ; Giuseppe Plazzi ; Pasquale MontagnaSource :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
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Abstract
Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21342
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ISTEX:3D616CF951A1997078440AFD5E902424EC03724ALe document en format XML
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Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v22:3</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2007-02-15">15 February 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="270" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21342</doi><idGroup><id type="unit" value="MDS21342"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2006 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2006-10-26"></event><event type="manuscriptAccepted" date="2006-10-28"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-01-17"></event><event type="firstOnline" date="2007-01-17"></event><event type="publishedOnlineFinalForm" date="2007-02-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">424</numbering><numbering type="pageLast">427</numbering></numberingGroup><correspondenceTo>Dipartimento di Scienze Neurologiche dell'Università di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21342.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="19"></count><count type="wordTotal" number="2581"></count></countGroup><titleGroup><title type="main" xml:lang="en">Augmentation of restless legs syndrome with long‐term tramadol treatment</title><title type="short" xml:lang="en">Tramadol and Restless Legs Syndrome Augmentation</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Roberto</givenNames><familyName>Vetrugno</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>vetrugno@neuro.unibo.it</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Chiara</givenNames><familyName>La Morgia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roberto</givenNames><familyName>D'Angelo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Daniela</givenNames><familyName>Loi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Federica</givenNames><familyName>Provini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Giuseppe</givenNames><familyName>Plazzi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Pasquale</givenNames><familyName>Montagna</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, University of Cagliari, Cagliari, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">restless legs syndrome</keyword><keyword xml:id="kwd2">augmentation</keyword><keyword xml:id="kwd3">opioids</keyword><keyword xml:id="kwd4">tramadol</keyword><keyword xml:id="kwd5">polysomnography</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Augmentation of restless legs syndrome with long‐term tramadol treatment</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Tramadol and Restless Legs Syndrome Augmentation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Augmentation of restless legs syndrome with long‐term tramadol treatment</title></titleInfo><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Vetrugno</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><description>Correspondence: Dipartimento di Scienze Neurologiche dell'Università di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chiara</namePart><namePart type="family">La Morgia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">D'Angelo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Loi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Cagliari, Cagliari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Federica</namePart><namePart type="family">Provini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Plazzi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pasquale</namePart><namePart type="family">Montagna</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-02-15</dateIssued><dateCaptured encoding="w3cdtf">2006-10-26</dateCaptured><dateValid encoding="w3cdtf">2006-10-28</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">19</extent><extent unit="words">2581</extent></physicalDescription><abstract lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>restless legs syndrome</topic><topic>augmentation</topic><topic>opioids</topic><topic>tramadol</topic><topic>polysomnography</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>424</start><end>427</end><total>4</total></extent></part></relatedItem><identifier type="istex">3D616CF951A1997078440AFD5E902424EC03724A</identifier><identifier type="DOI">10.1002/mds.21342</identifier><identifier type="ArticleID">MDS21342</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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