Augmentation of restless legs syndrome with long‐term tramadol treatment
Identifieur interne : 002D58 ( Istex/Corpus ); précédent : 002D57; suivant : 002D59Augmentation of restless legs syndrome with long‐term tramadol treatment
Auteurs : Roberto Vetrugno ; Chiara La Morgia ; Roberto D'Angelo ; Daniela Loi ; Federica Provini ; Giuseppe Plazzi ; Pasquale MontagnaSource :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
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Abstract
Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21342
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<p>Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</p>
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<!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Augmentation of restless legs syndrome with long‐term tramadol treatment</title>
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<titleInfo type="abbreviated" lang="en"><title>Tramadol and Restless Legs Syndrome Augmentation</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Augmentation of restless legs syndrome with long‐term tramadol treatment</title>
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<name type="personal"><namePart type="given">Roberto</namePart>
<namePart type="family">Vetrugno</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
<description>Correspondence: Dipartimento di Scienze Neurologiche dell'Università di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy</description>
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<name type="personal"><namePart type="given">Chiara</namePart>
<namePart type="family">La Morgia</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
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<name type="personal"><namePart type="given">Roberto</namePart>
<namePart type="family">D'Angelo</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
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<name type="personal"><namePart type="given">Daniela</namePart>
<namePart type="family">Loi</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, University of Cagliari, Cagliari, Italy</affiliation>
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<name type="personal"><namePart type="given">Federica</namePart>
<namePart type="family">Provini</namePart>
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<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
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<name type="personal"><namePart type="given">Giuseppe</namePart>
<namePart type="family">Plazzi</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
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<name type="personal"><namePart type="given">Pasquale</namePart>
<namePart type="family">Montagna</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurological Sciences, University of Bologna, Bologna, Italy</affiliation>
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<dateIssued encoding="w3cdtf">2007-02-15</dateIssued>
<dateCaptured encoding="w3cdtf">2006-10-26</dateCaptured>
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<abstract lang="en">Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long‐term treatment with tramadol, an opioid agonist with selectivity for μ‐receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. © 2006 Movement Disorder Society</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>restless legs syndrome</topic>
<topic>augmentation</topic>
<topic>opioids</topic>
<topic>tramadol</topic>
<topic>polysomnography</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
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<titleInfo type="abbreviated"><title>Mov. Disord.</title>
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<topic>Brief Report</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>22</number>
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<detail type="issue"><caption>no.</caption>
<number>3</number>
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<extent unit="pages"><start>424</start>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition>
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