Diffusion‐weighted imaging study of patients with essential tremor
Identifieur interne : 003E15 ( Main/Merge ); précédent : 003E14; suivant : 003E16Diffusion‐weighted imaging study of patients with essential tremor
Auteurs : Paolo Martinelli [Italie] ; Giovanni Rizzo [Italie] ; David Manners [Italie] ; Caterina Tonon [Italie] ; Fabio Pizza [Italie] ; Claudia Testa [Italie] ; Cesa Scaglione [Italie] ; Bruno Barbiroli [Italie] ; Raffaele Lodi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Brain (pathology), Diffusion Magnetic Resonance Imaging (methods), Essential Tremor (diagnosis), Essential Tremor (epidemiology), Female, Humans, Male, Middle Aged, Severity of Illness Index, apparent diffusion coefficient, cerebellum, diffusion‐weighted imaging, essential tremor, neurodegeneration.
- MESH :
- diagnosis : Essential Tremor.
- epidemiology : Essential Tremor.
- methods : Diffusion Magnetic Resonance Imaging.
- pathology : Brain.
- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21287
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<front><div type="abstract" xml:lang="fr">The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="fr">The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</div>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion-weighted imaging study of patients with essential tremor.</title>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
</author>
<author><name sortKey="Pizza, Fabio" sort="Pizza, Fabio" uniqKey="Pizza F" first="Fabio" last="Pizza">Fabio Pizza</name>
</author>
<author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name>
</author>
<author><name sortKey="Scaglione, Cesa" sort="Scaglione, Cesa" uniqKey="Scaglione C" first="Cesa" last="Scaglione">Cesa Scaglione</name>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
</author>
</titleStmt>
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<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21287</idno>
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<idno type="wicri:doubleKey">0885-3185:2007:Martinelli P:diffusion:weighted:imaging</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Diffusion-weighted imaging study of patients with essential tremor.</title>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
</author>
<author><name sortKey="Pizza, Fabio" sort="Pizza, Fabio" uniqKey="Pizza F" first="Fabio" last="Pizza">Fabio Pizza</name>
</author>
<author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name>
</author>
<author><name sortKey="Scaglione, Cesa" sort="Scaglione, Cesa" uniqKey="Scaglione C" first="Cesa" last="Scaglione">Cesa Scaglione</name>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Brain (pathology)</term>
<term>Diffusion Magnetic Resonance Imaging (methods)</term>
<term>Essential Tremor (diagnosis)</term>
<term>Essential Tremor (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and (1)H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out.</div>
</front>
</TEI>
</PubMed>
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