Diffusion‐weighted imaging study of patients with essential tremor
Identifieur interne : 002F91 ( Istex/Corpus ); précédent : 002F90; suivant : 002F92Diffusion‐weighted imaging study of patients with essential tremor
Auteurs : Paolo Martinelli ; Giovanni Rizzo ; David Manners ; Caterina Tonon ; Fabio Pizza ; Claudia Testa ; Cesa Scaglione ; Bruno Barbiroli ; Raffaele LodiSource :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
English descriptors
- KwdEn :
Abstract
The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21287
Links to Exploration step
ISTEX:D7A20BE7828EE8391AF77CD53430AE61405865CALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion‐weighted imaging study of patients with essential tremor</title>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Pizza, Fabio" sort="Pizza, Fabio" uniqKey="Pizza F" first="Fabio" last="Pizza">Fabio Pizza</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Scaglione, Cesa" sort="Scaglione, Cesa" uniqKey="Scaglione C" first="Cesa" last="Scaglione">Cesa Scaglione</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D7A20BE7828EE8391AF77CD53430AE61405865CA</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21287</idno>
<idno type="url">https://api.istex.fr/document/D7A20BE7828EE8391AF77CD53430AE61405865CA/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002F91</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diffusion‐weighted imaging study of patients with essential tremor</title>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Pizza, Fabio" sort="Pizza, Fabio" uniqKey="Pizza F" first="Fabio" last="Pizza">Fabio Pizza</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Scaglione, Cesa" sort="Scaglione, Cesa" uniqKey="Scaglione C" first="Cesa" last="Scaglione">Cesa Scaglione</name>
<affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-06-15">2007-06-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1182">1182</biblScope>
<biblScope unit="page" to="1185">1185</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">D7A20BE7828EE8391AF77CD53430AE61405865CA</idno>
<idno type="DOI">10.1002/mds.21287</idno>
<idno type="ArticleID">MDS21287</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>apparent diffusion coefficient</term>
<term>cerebellum</term>
<term>diffusion‐weighted imaging</term>
<term>essential tremor</term>
<term>neurodegeneration</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="fr">The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<istex><corpusName>wiley</corpusName>
<author><json:item><name>Paolo Martinelli MD</name>
<affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Giovanni Rizzo MD</name>
<affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>David Manners DPhil</name>
<affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Caterina Tonon MD</name>
<affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Fabio Pizza MD</name>
<affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Claudia Testa PhD</name>
<affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Cesa Scaglione MD</name>
<affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Bruno Barbiroli MD</name>
<affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
<json:item><name>Raffaele Lodi MD</name>
<affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>essential tremor</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>diffusion‐weighted imaging</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>cerebellum</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>apparent diffusion coefficient</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>neurodegeneration</value>
</json:item>
</subject>
<language><json:string>eng</json:string>
</language>
<abstract>The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</abstract>
<qualityIndicators><score>3.968</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>594 x 792 pts</pdfPageSize>
<refBibsNative>true</refBibsNative>
<abstractCharCount>1085</abstractCharCount>
<pdfWordCount>2108</pdfWordCount>
<pdfCharCount>14324</pdfCharCount>
<pdfPageCount>4</pdfPageCount>
<abstractWordCount>155</abstractWordCount>
</qualityIndicators>
<title>Diffusion‐weighted imaging study of patients with essential tremor</title>
<genre><json:string>Serial article</json:string>
</genre>
<host><volume>22</volume>
<pages><total>5</total>
<last>1185</last>
<first>1182</first>
</pages>
<issn><json:string>0885-3185</json:string>
</issn>
<issue>8</issue>
<subject><json:item><value>Brief Report</value>
</json:item>
</subject>
<genre></genre>
<language><json:string>unknown</json:string>
</language>
<title>Movement Disorders</title>
<doi><json:string>10.1002/(ISSN)1531-8257</json:string>
</doi>
</host>
<publicationDate>2007</publicationDate>
<copyrightDate>2007</copyrightDate>
<doi><json:string>10.1002/mds.21287</json:string>
</doi>
<id>D7A20BE7828EE8391AF77CD53430AE61405865CA</id>
<fulltext><json:item><original>true</original>
<mimetype>application/pdf</mimetype>
<extension>pdf</extension>
<uri>https://api.istex.fr/document/D7A20BE7828EE8391AF77CD53430AE61405865CA/fulltext/pdf</uri>
</json:item>
<json:item><original>false</original>
<mimetype>application/zip</mimetype>
<extension>zip</extension>
<uri>https://api.istex.fr/document/D7A20BE7828EE8391AF77CD53430AE61405865CA/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/D7A20BE7828EE8391AF77CD53430AE61405865CA/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Diffusion‐weighted imaging study of patients with essential tremor</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<availability><p>Wiley Subscription Services, Inc., A Wiley Company</p>
</availability>
<date>2007</date>
</publicationStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Diffusion‐weighted imaging study of patients with essential tremor</title>
<author><persName><forename type="first">Paolo</forename>
<surname>Martinelli</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Giovanni</forename>
<surname>Rizzo</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">David</forename>
<surname>Manners</surname>
<roleName type="degree">DPhil</roleName>
</persName>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Caterina</forename>
<surname>Tonon</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Fabio</forename>
<surname>Pizza</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Claudia</forename>
<surname>Testa</surname>
<roleName type="degree">PhD</roleName>
</persName>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Cesa</forename>
<surname>Scaglione</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Bruno</forename>
<surname>Barbiroli</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
</author>
<author><persName><forename type="first">Raffaele</forename>
<surname>Lodi</surname>
<roleName type="degree">MD</roleName>
</persName>
<note type="correspondence"><p>Correspondence: Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci,” Università di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy</p>
</note>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
</author>
</analytic>
<monogr><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="pISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<idno type="DOI">10.1002/(ISSN)1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-06-15"></date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1182">1182</biblScope>
<biblScope unit="page" to="1185">1185</biblScope>
</imprint>
</monogr>
<idno type="istex">D7A20BE7828EE8391AF77CD53430AE61405865CA</idno>
<idno type="DOI">10.1002/mds.21287</idno>
<idno type="ArticleID">MDS21287</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>2007</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="fr"><p>The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</p>
</abstract>
<textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head>
<item><term>essential tremor</term>
</item>
<item><term>diffusion‐weighted imaging</term>
</item>
<item><term>cerebellum</term>
</item>
<item><term>apparent diffusion coefficient</term>
</item>
<item><term>neurodegeneration</term>
</item>
</list>
</keywords>
</textClass>
<textClass><keywords scheme="Journal Subject"><list><head>Article category</head>
<item><term>Brief Report</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="2006-06-20">Received</change>
<change when="2006-09-17">Registration</change>
<change when="2007-06-15">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><original>false</original>
<mimetype>text/plain</mimetype>
<extension>txt</extension>
<uri>https://api.istex.fr/document/D7A20BE7828EE8391AF77CD53430AE61405865CA/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName>
<publisherLoc>Hoboken</publisherLoc>
</publisherInfo>
<doi registered="yes">10.1002/(ISSN)1531-8257</doi>
<issn type="print">0885-3185</issn>
<issn type="electronic">1531-8257</issn>
<idGroup><id type="product" value="MDS"></id>
</idGroup>
<titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title>
<title type="short">Mov. Disord.</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/mds.v22:8</doi>
<numberingGroup><numbering type="journalVolume" number="22">22</numbering>
<numbering type="journalIssue">8</numbering>
</numberingGroup>
<coverDate startDate="2007-06-15">15 June 2007</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="article" position="210" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21287</doi>
<idGroup><id type="unit" value="MDS21287"></id>
</idGroup>
<countGroup><count type="pageTotal" number="5"></count>
</countGroup>
<titleGroup><title type="articleCategory">Brief Report</title>
<title type="tocHeading1">Brief Reports</title>
</titleGroup>
<copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright>
<eventGroup><event type="manuscriptReceived" date="2006-06-20"></event>
<event type="manuscriptRevised" date="2006-09-09"></event>
<event type="manuscriptAccepted" date="2006-09-17"></event>
<event type="firstOnline" date="2007-04-27"></event>
<event type="publishedOnlineFinalForm" date="2007-06-19"></event>
<event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2007-04-27"></event>
<event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event>
</eventGroup>
<numberingGroup><numbering type="pageFirst">1182</numbering>
<numbering type="pageLast">1185</numbering>
</numberingGroup>
<correspondenceTo>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci,” Università di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy</correspondenceTo>
<linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21287.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta><countGroup><count type="figureTotal" number="1"></count>
<count type="tableTotal" number="2"></count>
<count type="referenceTotal" number="17"></count>
<count type="wordTotal" number="2584"></count>
</countGroup>
<titleGroup><title type="main" xml:lang="en">Diffusion‐weighted imaging study of patients with essential tremor</title>
<title type="short" xml:lang="en">Diffusion‐Weighted Imaging Study</title>
</titleGroup>
<creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paolo</givenNames>
<familyName>Martinelli</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Giovanni</givenNames>
<familyName>Rizzo</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>David</givenNames>
<familyName>Manners</familyName>
<degrees>DPhil</degrees>
</personName>
</creator>
<creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Caterina</givenNames>
<familyName>Tonon</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Fabio</givenNames>
<familyName>Pizza</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Claudia</givenNames>
<familyName>Testa</familyName>
<degrees>PhD</degrees>
</personName>
</creator>
<creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Cesa</givenNames>
<familyName>Scaglione</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Bruno</givenNames>
<familyName>Barbiroli</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au9" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Raffaele</givenNames>
<familyName>Lodi</familyName>
<degrees>MD</degrees>
</personName>
<contactDetails><email>raffaele.lodi@unibo.it</email>
</contactDetails>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">essential tremor</keyword>
<keyword xml:id="kwd2">diffusion‐weighted imaging</keyword>
<keyword xml:id="kwd3">cerebellum</keyword>
<keyword xml:id="kwd4">apparent diffusion coefficient</keyword>
<keyword xml:id="kwd5">neurodegeneration</keyword>
</keywordGroup>
<abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title>
<p>The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and <sup>1</sup>
H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Diffusion‐weighted imaging study of patients with essential tremor</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Diffusion‐Weighted Imaging Study</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diffusion‐weighted imaging study of patients with essential tremor</title>
</titleInfo>
<name type="personal"><namePart type="given">Paolo</namePart>
<namePart type="family">Martinelli</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Giovanni</namePart>
<namePart type="family">Rizzo</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">David</namePart>
<namePart type="family">Manners</namePart>
<namePart type="termsOfAddress">DPhil</namePart>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Caterina</namePart>
<namePart type="family">Tonon</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Fabio</namePart>
<namePart type="family">Pizza</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Claudia</namePart>
<namePart type="family">Testa</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Cesa</namePart>
<namePart type="family">Scaglione</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Bruno</namePart>
<namePart type="family">Barbiroli</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Raffaele</namePart>
<namePart type="family">Lodi</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata, Università di Bologna, Bologna, Italy</affiliation>
<description>Correspondence: Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci,” Università di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre authority="originalCategForm">article</genre>
<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2007-06-15</dateIssued>
<dateCaptured encoding="w3cdtf">2006-06-20</dateCaptured>
<dateValid encoding="w3cdtf">2006-09-17</dateValid>
<copyrightDate encoding="w3cdtf">2007</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
<extent unit="figures">1</extent>
<extent unit="tables">2</extent>
<extent unit="references">17</extent>
<extent unit="words">2584</extent>
</physicalDescription>
<abstract lang="fr">The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H‐MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion‐weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. © 2007 Movement Disorder Society</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>essential tremor</topic>
<topic>diffusion‐weighted imaging</topic>
<topic>cerebellum</topic>
<topic>apparent diffusion coefficient</topic>
<topic>neurodegeneration</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<subject><genre>article category</genre>
<topic>Brief Report</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>22</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>8</number>
</detail>
<extent unit="pages"><start>1182</start>
<end>1185</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">D7A20BE7828EE8391AF77CD53430AE61405865CA</identifier>
<identifier type="DOI">10.1002/mds.21287</identifier>
<identifier type="ArticleID">MDS21287</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F91 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002F91 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:D7A20BE7828EE8391AF77CD53430AE61405865CA |texte= Diffusion‐weighted imaging study of patients with essential tremor }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |