MovDisordV3, Main, Merge, bibRecord, 003D59

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Identifieur interne : 003D59 ( Main/Merge ); précédent : 003D58; suivant : 003D60

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Auteurs : Irena Rektorova [République tchèque] ; Jennifer Barrett [Canada] ; Michal Mikl [République tchèque] ; Ivan Rektor [République tchèque] ; Tomas Paus [Canada, Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-10-31.

RBID : ISTEX:897AF6BEA47119314C32CE08B2768E58EEA5EE2E

English descriptors

KwdEn :
- Acoustic Stimulation (methods), Aged, Brain Mapping, Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Middle Aged, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson's disease, Somatosensory Cortex (blood supply), Somatosensory Cortex (physiopathology), Speech (physiology), Speech Acoustics, Statistics as Topic, functional magnetic resonance imaging, overt reading, paralinguistic aspects of speech.
MESH :
- chemical , blood : Oxygen.
- blood supply : Somatosensory Cortex.
- methods : Acoustic Stimulation, Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Speech.
- physiopathology : Parkinson Disease, Somatosensory Cortex.
- Aged, Brain Mapping, Case-Control Studies, Female, Humans, Middle Aged, Speech Acoustics, Statistics as Topic.

Abstract

Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level‐dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 ± 11.6 years, mean levodopa equivalent 583.3 ± 397.9 mg) and (2) 8 age‐matched healthy female controls (age; mean 62.2 years ± 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading‐baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age‐matched controls. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/897AF6BEA47119314C32CE08B2768E58EEA5EE2E/fulltext/pdf

DOI: 10.1002/mds.21548

Links to Exploration step

ISTEX:897AF6BEA47119314C32CE08B2768E58EEA5EE2E

Le document en format XML

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<term>Statistics as Topic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Somatosensory Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Speech</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Somatosensory Cortex</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Brain Mapping</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Speech Acoustics</term>
<term>Statistics as Topic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level-dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 +/- 11.6 years, mean levodopa equivalent 583.3 +/- 397.9 mg) and (2) 8 age-matched healthy female controls (age; mean 62.2 years +/- 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading-baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age-matched controls.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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Movement Disorders (revue)

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

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