Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.
Identifieur interne : 002567 ( PubMed/Corpus ); précédent : 002566; suivant : 002568Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.
Auteurs : Irena Rektorova ; Jennifer Barrett ; Michal Mikl ; Ivan Rektor ; Tomas PausSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Aged, Brain Mapping, Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Middle Aged, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Somatosensory Cortex (blood supply), Somatosensory Cortex (physiopathology), Speech (physiology), Speech Acoustics, Statistics as Topic.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Somatosensory Cortex.
- methods : Acoustic Stimulation, Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Speech.
- physiopathology : Parkinson Disease, Somatosensory Cortex.
- Aged, Brain Mapping, Case-Control Studies, Female, Humans, Middle Aged, Speech Acoustics, Statistics as Topic.
Abstract
Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level-dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 +/- 11.6 years, mean levodopa equivalent 583.3 +/- 397.9 mg) and (2) 8 age-matched healthy female controls (age; mean 62.2 years +/- 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading-baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age-matched controls.
DOI: 10.1002/mds.21548
PubMed: 17683056
Links to Exploration step
pubmed:17683056Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.</title><author><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name><affiliation><nlm:affiliation>1st Department of Neurology, Masaryk University, St Anne's Hospital, Brno, Czech Republic. irena.rektorova@fnusa.cz</nlm:affiliation></affiliation></author><author><name sortKey="Barrett, Jennifer" sort="Barrett, Jennifer" uniqKey="Barrett J" first="Jennifer" last="Barrett">Jennifer Barrett</name></author><author><name sortKey="Mikl, Michal" sort="Mikl, Michal" uniqKey="Mikl M" first="Michal" last="Mikl">Michal Mikl</name></author><author><name sortKey="Rektor, Ivan" sort="Rektor, Ivan" uniqKey="Rektor I" first="Ivan" last="Rektor">Ivan Rektor</name></author><author><name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomas" last="Paus">Tomas Paus</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21548</idno><idno type="RBID">pubmed:17683056</idno><idno type="pmid">17683056</idno><idno type="wicri:Area/PubMed/Corpus">002567</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.</title><author><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name><affiliation><nlm:affiliation>1st Department of Neurology, Masaryk University, St Anne's Hospital, Brno, Czech Republic. irena.rektorova@fnusa.cz</nlm:affiliation></affiliation></author><author><name sortKey="Barrett, Jennifer" sort="Barrett, Jennifer" uniqKey="Barrett J" first="Jennifer" last="Barrett">Jennifer Barrett</name></author><author><name sortKey="Mikl, Michal" sort="Mikl, Michal" uniqKey="Mikl M" first="Michal" last="Mikl">Michal Mikl</name></author><author><name sortKey="Rektor, Ivan" sort="Rektor, Ivan" uniqKey="Rektor I" first="Ivan" last="Rektor">Ivan Rektor</name></author><author><name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomas" last="Paus">Tomas Paus</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (methods)</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Middle Aged</term><term>Oxygen (blood)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Somatosensory Cortex (blood supply)</term><term>Somatosensory Cortex (physiopathology)</term><term>Speech (physiology)</term><term>Speech Acoustics</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Speech</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Speech Acoustics</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level-dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 +/- 11.6 years, mean levodopa equivalent 583.3 +/- 397.9 mg) and (2) 8 age-matched healthy female controls (age; mean 62.2 years +/- 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading-baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age-matched controls.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17683056</PMID><DateCreated><Year>2007</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2008</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>14</Issue><PubDate><Year>2007</Year><Month>Oct</Month><Day>31</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2043-51</MedlinePgn></Pagination><Abstract><AbstractText>Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level-dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 +/- 11.6 years, mean levodopa equivalent 583.3 +/- 397.9 mg) and (2) 8 age-matched healthy female controls (age; mean 62.2 years +/- 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading-baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age-matched controls.</AbstractText><CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rektorova</LastName><ForeName>Irena</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>1st Department of Neurology, Masaryk University, St Anne's Hospital, Brno, Czech Republic. irena.rektorova@fnusa.cz</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barrett</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mikl</LastName><ForeName>Michal</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rektor</LastName><ForeName>Ivan</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Paus</LastName><ForeName>Tomas</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000161">Acoustic Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010100">Oxygen</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013003">Somatosensory Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000098">blood supply</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013060">Speech</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013061">Speech Acoustics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013223">Statistics as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>2</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21548</ArticleId><ArticleId IdType="pubmed">17683056</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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