MovDisordV3, Main, Merge, bibRecord, 003C46

Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]‐PK11195 PET

Identifieur interne : 003C46 ( Main/Merge ); précédent : 003C45; suivant : 003C47

Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]‐PK11195 PET

Auteurs : Anna L. Bartels [Pays-Bas] ; Klaus L. Leenders [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-10-15.

RBID : ISTEX:7B3CD30B96FB51BA2CC4049A6453CF0843C98704

English descriptors

KwdEn :
- Animals, Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Brain (immunology), Brain (radionuclide imaging), COX‐2 inhibition, Cyclooxygenase 2 (blood), Cytokines (blood), Disease Models, Animal, Humans, Inflammation Mediators (blood), Isoquinolines (diagnostic use), Microglia (immunology), Nerve Degeneration (immunology), Nerve Degeneration (radionuclide imaging), Nitric Oxide Synthase Type II (blood), PK11195 PET, Parkinson's disease, Parkinsonian Disorders (immunology), Parkinsonian Disorders (radionuclide imaging), Positron-Emission Tomography, Reactive Oxygen Species (immunology), microglia, neuroinflammation, neuroprotection.
MESH :
- chemical , blood : Cyclooxygenase 2, Cytokines, Inflammation Mediators, Nitric Oxide Synthase Type II.
- chemical , diagnostic use : Isoquinolines.
- chemical , immunology : Reactive Oxygen Species.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal.
- immunology : Brain, Microglia, Nerve Degeneration, Parkinsonian Disorders.
- radionuclide imaging : Brain, Nerve Degeneration, Parkinsonian Disorders.
- Animals, Disease Models, Animal, Humans, Positron-Emission Tomography.

Abstract

Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up‐regulation of inflammatory‐associated factors as cyclo‐oxygenase‐2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/7B3CD30B96FB51BA2CC4049A6453CF0843C98704/fulltext/pdf

DOI: 10.1002/mds.21552

Links to Exploration step

ISTEX:7B3CD30B96FB51BA2CC4049A6453CF0843C98704

Le document en format XML

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<front><div type="abstract" xml:lang="en">Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up‐regulation of inflammatory‐associated factors as cyclo‐oxygenase‐2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up-regulation of inflammatory-associated factors as cyclo-oxygenase-2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD.</div>
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Movement Disorders (revue)

Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]‐PK11195 PET

Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]‐PK11195 PET

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English descriptors

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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