MovDisordV3, PubMed, Checkpoint, bibRecord, 002696

Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.

Identifieur interne : 002696 ( PubMed/Checkpoint ); précédent : 002695; suivant : 002697

Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.

Auteurs : Anna L. Bartels [Pays-Bas] ; Klaus L. Leenders

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17592621

English descriptors

KwdEn :
- Animals, Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Brain (immunology), Brain (radionuclide imaging), Cyclooxygenase 2 (blood), Cytokines (blood), Disease Models, Animal, Humans, Inflammation Mediators (blood), Isoquinolines (diagnostic use), Microglia (immunology), Nerve Degeneration (immunology), Nerve Degeneration (radionuclide imaging), Nitric Oxide Synthase Type II (blood), Parkinsonian Disorders (immunology), Parkinsonian Disorders (radionuclide imaging), Positron-Emission Tomography, Reactive Oxygen Species (immunology).
MESH :
- chemical , blood : Cyclooxygenase 2, Cytokines, Inflammation Mediators, Nitric Oxide Synthase Type II.
- chemical , diagnostic use : Isoquinolines.
- chemical , immunology : Reactive Oxygen Species.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal.
- immunology : Brain, Microglia, Nerve Degeneration, Parkinsonian Disorders.
- radionuclide imaging : Brain, Nerve Degeneration, Parkinsonian Disorders.
- Animals, Disease Models, Animal, Humans, Positron-Emission Tomography.

Abstract

Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up-regulation of inflammatory-associated factors as cyclo-oxygenase-2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD.

DOI: 10.1002/mds.21552
PubMed: 17592621

Affiliations:

Pays-Bas

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Le document en format XML

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<author><name sortKey="Bartels, Anna L" sort="Bartels, Anna L" uniqKey="Bartels A" first="Anna L" last="Bartels">Anna L. Bartels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. a.l.bartels@neuro.umcg.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up-regulation of inflammatory-associated factors as cyclo-oxygenase-2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD.</div>
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<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.

Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki