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Botulinum Neurotoxin Type A Injections Reduce Spasticity in Mild to Moderate Hereditary Spastic Paraplegia : Report of 19 Cases

Identifieur interne : 003952 ( Main/Merge ); précédent : 003951; suivant : 003953

Botulinum Neurotoxin Type A Injections Reduce Spasticity in Mild to Moderate Hereditary Spastic Paraplegia : Report of 19 Cases

Auteurs : Martin J. Hecht [Allemagne] ; Henning Stolze [Allemagne] ; Matthias Auf Dem Brinke [Allemagne] ; Ralf Giess [Allemagne] ; Thoams Treig [Allemagne] ; Martin Winterholler [Allemagne] ; Jorg Wissel [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0133665

Descripteurs français

Pascal (Inist)
- Hypertonie spastique, Paraplégie spasmodique héréditaire de Strümpell-Lorrain, Pathologie du système nerveux, Bontoxilysin, Etude cas, Traitement.

English descriptors

KwdEn :
- Bontoxilysin, Case study, Hereditary spastic paraplegia, Nervous system diseases, Spasticity, Treatment.

Abstract

Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT-A) might also be considered for patients with HSP. We report the effect of BoNT-A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT-A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT-A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT-A injections in HSP.

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Pascal:08-0133665

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Botulinum Neurotoxin Type A Injections Reduce Spasticity in Mild to Moderate Hereditary Spastic Paraplegia : Report of 19 Cases</title>
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<term>Hereditary spastic paraplegia</term>
<term>Nervous system diseases</term>
<term>Spasticity</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertonie spastique</term>
<term>Paraplégie spasmodique héréditaire de Strümpell-Lorrain</term>
<term>Pathologie du   système nerveux</term>
<term>Bontoxilysin</term>
<term>Etude cas</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT-A) might also be considered for patients with HSP. We report the effect of BoNT-A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT-A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT-A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT-A injections in HSP.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Basse-Saxe</li>
<li>Bavière</li>
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<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J." last="Hecht">Martin J. Hecht</name>
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<name sortKey="Dem Brinke, Matthias Auf" sort="Dem Brinke, Matthias Auf" uniqKey="Dem Brinke M" first="Matthias Auf" last="Dem Brinke">Matthias Auf Dem Brinke</name>
<name sortKey="Giess, Ralf" sort="Giess, Ralf" uniqKey="Giess R" first="Ralf" last="Giess">Ralf Giess</name>
<name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J." last="Hecht">Martin J. Hecht</name>
<name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name>
<name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name>
<name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name>
<name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name>
<name sortKey="Winterholler, Martin" sort="Winterholler, Martin" uniqKey="Winterholler M" first="Martin" last="Winterholler">Martin Winterholler</name>
<name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jorg" last="Wissel">Jorg Wissel</name>
</country>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Botulinum Neurotoxin Type A Injections Reduce Spasticity in Mild to Moderate Hereditary Spastic Paraplegia : Report of 19 Cases

Botulinum Neurotoxin Type A Injections Reduce Spasticity in Mild to Moderate Hereditary Spastic Paraplegia : Report of 19 Cases

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri