MovDisordV3, Main, Merge, bibRecord, 003801

Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Identifieur interne : 003801 ( Main/Merge ); précédent : 003800; suivant : 003802

Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Auteurs : David Maltete [France] ; Stéphane Derrey [France] ; Nathalie Chastan [France] ; Bertrand Debono [France] ; Emmanuel Gerardin [France] ; Pierre Freger [France] ; Bruno Mihout [France] ; Jean Francois Menard [France] ; Didier Hannequin [France]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0305155

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Long terme, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Long term, Nervous system diseases, Parkinson disease, Subthalamic nucleus.

Abstract

A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.

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Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</div>
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<name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name>
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<name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name>
<name sortKey="Francois Menard, Jean" sort="Francois Menard, Jean" uniqKey="Francois Menard J" first="Jean" last="Francois Menard">Jean Francois Menard</name>
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<name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gerardin">Emmanuel Gerardin</name>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri