Movement Disorders (revue)

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Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Identifieur interne : 001230 ( PascalFrancis/Corpus ); précédent : 001229; suivant : 001231

Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease

Auteurs : David Maltete ; Stéphane Derrey ; Nathalie Chastan ; Bertrand Debono ; Emmanuel Gerardin ; Pierre Freger ; Bruno Mihout ; Jean Francois Menard ; Didier Hannequin

Source :

RBID : Pascal:08-0305155

Descripteurs français

English descriptors

Abstract

A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 23
A06       @2 7
A08 01  1  ENG  @1 Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease
A11 01  1    @1 MALTETE (David)
A11 02  1    @1 DERREY (Stéphane)
A11 03  1    @1 CHASTAN (Nathalie)
A11 04  1    @1 DEBONO (Bertrand)
A11 05  1    @1 GERARDIN (Emmanuel)
A11 06  1    @1 FREGER (Pierre)
A11 07  1    @1 MIHOUT (Bruno)
A11 08  1    @1 FRANCOIS MENARD (Jean)
A11 09  1    @1 HANNEQUIN (Didier)
A14 01      @1 Department of Neurology, Rouen University Hospital @2 Rouen @3 FRA @Z 1 aut. @Z 7 aut. @Z 9 aut.
A14 02      @1 INSERM U614, Rouen Faculty of Medicine Rouen @3 FRA @Z 1 aut. @Z 9 aut.
A14 03      @1 Department of Neurosurgery, Rouen University Hospital @2 Rouen @3 FRA @Z 2 aut. @Z 4 aut. @Z 6 aut.
A14 04      @1 Laboratory of Neurophysiology, Rouen University Hospital @2 Rouen @3 FRA @Z 3 aut.
A14 05      @1 Department of Radiology, Rouen University Hospital @2 Rouen @3 FRA @Z 5 aut.
A14 06      @1 Department of Biostatistics, Rouen University Hospital @2 Rouen @3 FRA @Z 8 aut.
A20       @1 1047-1050
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000200276040200
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 21 ref.
A47 01  1    @0 08-0305155
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C03 01  X  FRE  @0 Maladie de Parkinson @2 NM @5 01
C03 01  X  ENG  @0 Parkinson disease @2 NM @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @2 NM @5 01
C03 02  X  FRE  @0 Pathologie du système nerveux @5 02
C03 02  X  ENG  @0 Nervous system diseases @5 02
C03 02  X  SPA  @0 Sistema nervioso patología @5 02
C03 03  X  FRE  @0 Long terme @5 09
C03 03  X  ENG  @0 Long term @5 09
C03 03  X  SPA  @0 Largo plazo @5 09
C03 04  X  FRE  @0 Noyau sousthalamique @5 10
C03 04  X  ENG  @0 Subthalamic nucleus @5 10
C03 04  X  SPA  @0 Núcleo subtalámico @5 10
C03 05  X  FRE  @0 Stimulation cérébrale profonde @4 CD @5 96
C03 05  X  ENG  @0 Deep brain stimulation @4 CD @5 96
C07 01  X  FRE  @0 Pathologie de l'encéphale @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Syndrome extrapyramidal @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
C07 05  X  FRE  @0 Encéphale @5 42
C07 05  X  ENG  @0 Encephalon @5 42
C07 05  X  SPA  @0 Encéfalo @5 42
C07 06  X  FRE  @0 Système nerveux central @5 43
C07 06  X  ENG  @0 Central nervous system @5 43
C07 06  X  SPA  @0 Sistema nervioso central @5 43
N21       @1 189
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 08-0305155 INIST
ET : Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease
AU : MALTETE (David); DERREY (Stéphane); CHASTAN (Nathalie); DEBONO (Bertrand); GERARDIN (Emmanuel); FREGER (Pierre); MIHOUT (Bruno); FRANCOIS MENARD (Jean); HANNEQUIN (Didier)
AF : Department of Neurology, Rouen University Hospital/Rouen/France (1 aut., 7 aut., 9 aut.); INSERM U614, Rouen Faculty of Medicine Rouen/France (1 aut., 9 aut.); Department of Neurosurgery, Rouen University Hospital/Rouen/France (2 aut., 4 aut., 6 aut.); Laboratory of Neurophysiology, Rouen University Hospital/Rouen/France (3 aut.); Department of Radiology, Rouen University Hospital/Rouen/France (5 aut.); Department of Biostatistics, Rouen University Hospital/Rouen/France (8 aut.)
DT : Publication en série; Courte communication, note brève; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1047-1050; Bibl. 21 ref.
LA : Anglais
EA : A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.
CC : 002B17; 002B17G
FD : Maladie de Parkinson; Pathologie du système nerveux; Long terme; Noyau sousthalamique; Stimulation cérébrale profonde
FG : Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central
ED : Parkinson disease; Nervous system diseases; Long term; Subthalamic nucleus; Deep brain stimulation
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system
SD : Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Núcleo subtalámico
LO : INIST-20953.354000200276040200
ID : 08-0305155

Links to Exploration step

Pascal:08-0305155

Le document en format XML

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<div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</div>
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<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Laboratory of Neurophysiology, Rouen University Hospital</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>Department of Radiology, Rouen University Hospital</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06">
<s1>Department of Biostatistics, Rouen University Hospital</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20>
<s1>1047-1050</s1>
</fA20>
<fA21>
<s1>2008</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
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<s1>INIST</s1>
<s2>20953</s2>
<s5>354000200276040200</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>21 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>08-0305155</s0>
</fA47>
<fA60>
<s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Movement disorders</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Pathologie du système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Long terme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Long term</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Largo plazo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Noyau sousthalamique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Subthalamic nucleus</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Núcleo subtalámico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21>
<s1>189</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
<server>
<NO>PASCAL 08-0305155 INIST</NO>
<ET>Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease</ET>
<AU>MALTETE (David); DERREY (Stéphane); CHASTAN (Nathalie); DEBONO (Bertrand); GERARDIN (Emmanuel); FREGER (Pierre); MIHOUT (Bruno); FRANCOIS MENARD (Jean); HANNEQUIN (Didier)</AU>
<AF>Department of Neurology, Rouen University Hospital/Rouen/France (1 aut., 7 aut., 9 aut.); INSERM U614, Rouen Faculty of Medicine Rouen/France (1 aut., 9 aut.); Department of Neurosurgery, Rouen University Hospital/Rouen/France (2 aut., 4 aut., 6 aut.); Laboratory of Neurophysiology, Rouen University Hospital/Rouen/France (3 aut.); Department of Radiology, Rouen University Hospital/Rouen/France (5 aut.); Department of Biostatistics, Rouen University Hospital/Rouen/France (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1047-1050; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Long terme; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Long term; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Núcleo subtalámico</SD>
<LO>INIST-20953.354000200276040200</LO>
<ID>08-0305155</ID>
</server>
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