Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease
Identifieur interne : 001230 ( PascalFrancis/Corpus ); précédent : 001229; suivant : 001231Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease
Auteurs : David Maltete ; Stéphane Derrey ; Nathalie Chastan ; Bertrand Debono ; Emmanuel Gerardin ; Pierre Freger ; Bruno Mihout ; Jean Francois Menard ; Didier HannequinSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.
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Format Inist (serveur)
NO : | PASCAL 08-0305155 INIST |
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ET : | Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease |
AU : | MALTETE (David); DERREY (Stéphane); CHASTAN (Nathalie); DEBONO (Bertrand); GERARDIN (Emmanuel); FREGER (Pierre); MIHOUT (Bruno); FRANCOIS MENARD (Jean); HANNEQUIN (Didier) |
AF : | Department of Neurology, Rouen University Hospital/Rouen/France (1 aut., 7 aut., 9 aut.); INSERM U614, Rouen Faculty of Medicine Rouen/France (1 aut., 9 aut.); Department of Neurosurgery, Rouen University Hospital/Rouen/France (2 aut., 4 aut., 6 aut.); Laboratory of Neurophysiology, Rouen University Hospital/Rouen/France (3 aut.); Department of Radiology, Rouen University Hospital/Rouen/France (5 aut.); Department of Biostatistics, Rouen University Hospital/Rouen/France (8 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1047-1050; Bibl. 21 ref. |
LA : | Anglais |
EA : | A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Long terme; Noyau sousthalamique; Stimulation cérébrale profonde |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Long term; Subthalamic nucleus; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system |
SD : | Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Núcleo subtalámico |
LO : | INIST-20953.354000200276040200 |
ID : | 08-0305155 |
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Pascal:08-0305155Le document en format XML
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<front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</div>
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</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21><s1>189</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0305155 INIST</NO>
<ET>Microsubthalamotomy : An Immediate Predictor of Long-Term Subthalamic Stimulation Efficacy in Parkinson Disease</ET>
<AU>MALTETE (David); DERREY (Stéphane); CHASTAN (Nathalie); DEBONO (Bertrand); GERARDIN (Emmanuel); FREGER (Pierre); MIHOUT (Bruno); FRANCOIS MENARD (Jean); HANNEQUIN (Didier)</AU>
<AF>Department of Neurology, Rouen University Hospital/Rouen/France (1 aut., 7 aut., 9 aut.); INSERM U614, Rouen Faculty of Medicine Rouen/France (1 aut., 9 aut.); Department of Neurosurgery, Rouen University Hospital/Rouen/France (2 aut., 4 aut., 6 aut.); Laboratory of Neurophysiology, Rouen University Hospital/Rouen/France (3 aut.); Department of Radiology, Rouen University Hospital/Rouen/France (5 aut.); Department of Biostatistics, Rouen University Hospital/Rouen/France (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1047-1050; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Long terme; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Long term; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Núcleo subtalámico</SD>
<LO>INIST-20953.354000200276040200</LO>
<ID>08-0305155</ID>
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