MovDisordV3, Main, Merge, bibRecord, 003787

Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Identifieur interne : 003787 ( Main/Merge ); précédent : 003786; suivant : 003788

Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Auteurs : Jana Godau [Allemagne] ; Uwe Klose [Allemagne] ; Adriana Di Santo [Allemagne] ; Katherine Schweitzer [Allemagne] ; Daniela Berg [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0357271

Descripteurs français

Pascal (Inist)
- Anémie ferriprive, Syndrome des jambes sans repos, Pathologie du système nerveux, Encéphale, Imagerie RMN, Fer, Ultrason, Elément minéral.
Wicri :
- topic : Fer.

English descriptors

KwdEn :
- Encephalon, Inorganic element, Iron, Iron deficiency anemia, Nervous system diseases, Nuclear magnetic resonance imaging, Restless legs syndrome, Ultrasound.

Abstract

Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.

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Pascal:08-0357271

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Multiregional Brain Iron Deficiency in Restless Legs Syndrome</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Encephalon</term>
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<term>Imagerie RMN</term>
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<front><div type="abstract" xml:lang="en">Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name>
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<name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
<name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name>
<name sortKey="Klose, Uwe" sort="Klose, Uwe" uniqKey="Klose U" first="Uwe" last="Klose">Uwe Klose</name>
<name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri