Multiregional Brain Iron Deficiency in Restless Legs Syndrome
Identifieur interne : 001213 ( PascalFrancis/Corpus ); précédent : 001212; suivant : 001214Multiregional Brain Iron Deficiency in Restless Legs Syndrome
Auteurs : Jana Godau ; Uwe Klose ; Adriana Di Santo ; Katherine Schweitzer ; Daniela BergSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0357271 INIST |
---|---|
ET : | Multiregional Brain Iron Deficiency in Restless Legs Syndrome |
AU : | GODAU (Jana); KLOSE (Uwe); DI SANTO (Adriana); SCHWEITZER (Katherine); BERG (Daniela) |
AF : | Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen/Tuebingen/Allemagne (1 aut., 3 aut., 4 aut., 5 aut.); Section of Experimental MRI of the CNS, Department of Neuroradiology, University of Tuebingen/Tübingen/Allemagne (2 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 8; Pp. 1184-1187; Bibl. 16 ref. |
LA : | Anglais |
EA : | Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. |
CC : | 002B17; 002B17D |
FD : | Anémie ferriprive; Syndrome des jambes sans repos; Pathologie du système nerveux; Encéphale; Imagerie RMN; Fer; Ultrason; Elément minéral |
FG : | Système nerveux central; Hémopathie; Sidéropénie; Trouble neurologique; Trouble de la sensibilité; Maladie métabolique |
ED : | Iron deficiency anemia; Restless legs syndrome; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging; Iron; Ultrasound; Inorganic element |
EG : | Central nervous system; Hemopathy; Sideropenia; Neurological disorder; Sensitivity disorder; Metabolic diseases |
SD : | Anemia ferropénica; Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Imaginería RMN; Hierro; Ultrasonido; Elemento inorgánico |
LO : | INIST-20953.354000196042800160 |
ID : | 08-0357271 |
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Pascal:08-0357271Le document en format XML
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<front><div type="abstract" xml:lang="en">Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.</div>
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<ET>Multiregional Brain Iron Deficiency in Restless Legs Syndrome</ET>
<AU>GODAU (Jana); KLOSE (Uwe); DI SANTO (Adriana); SCHWEITZER (Katherine); BERG (Daniela)</AU>
<AF>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen/Tuebingen/Allemagne (1 aut., 3 aut., 4 aut., 5 aut.); Section of Experimental MRI of the CNS, Department of Neuroradiology, University of Tuebingen/Tübingen/Allemagne (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 8; Pp. 1184-1187; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.</EA>
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<ED>Iron deficiency anemia; Restless legs syndrome; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging; Iron; Ultrasound; Inorganic element</ED>
<EG>Central nervous system; Hemopathy; Sideropenia; Neurological disorder; Sensitivity disorder; Metabolic diseases</EG>
<SD>Anemia ferropénica; Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Imaginería RMN; Hierro; Ultrasonido; Elemento inorgánico</SD>
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