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Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Identifieur interne : 001213 ( PascalFrancis/Corpus ); précédent : 001212; suivant : 001214

Multiregional Brain Iron Deficiency in Restless Legs Syndrome

Auteurs : Jana Godau ; Uwe Klose ; Adriana Di Santo ; Katherine Schweitzer ; Daniela Berg

Source :

RBID : Pascal:08-0357271

Descripteurs français

English descriptors

Abstract

Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 23
A06       @2 8
A08 01  1  ENG  @1 Multiregional Brain Iron Deficiency in Restless Legs Syndrome
A11 01  1    @1 GODAU (Jana)
A11 02  1    @1 KLOSE (Uwe)
A11 03  1    @1 DI SANTO (Adriana)
A11 04  1    @1 SCHWEITZER (Katherine)
A11 05  1    @1 BERG (Daniela)
A14 01      @1 Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen @2 Tuebingen @3 DEU @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.
A14 02      @1 Section of Experimental MRI of the CNS, Department of Neuroradiology, University of Tuebingen @2 Tübingen @3 DEU @Z 2 aut.
A20       @1 1184-1187
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000196042800160
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 16 ref.
A47 01  1    @0 08-0357271
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.
C02 01  X    @0 002B17
C02 02  X    @0 002B17D
C03 01  X  FRE  @0 Anémie ferriprive @5 01
C03 01  X  ENG  @0 Iron deficiency anemia @5 01
C03 01  X  SPA  @0 Anemia ferropénica @5 01
C03 02  X  FRE  @0 Syndrome des jambes sans repos @5 02
C03 02  X  ENG  @0 Restless legs syndrome @5 02
C03 02  X  SPA  @0 Acroparestesia nocturna @5 02
C03 03  X  FRE  @0 Pathologie du système nerveux @5 03
C03 03  X  ENG  @0 Nervous system diseases @5 03
C03 03  X  SPA  @0 Sistema nervioso patología @5 03
C03 04  X  FRE  @0 Encéphale @5 09
C03 04  X  ENG  @0 Encephalon @5 09
C03 04  X  SPA  @0 Encéfalo @5 09
C03 05  X  FRE  @0 Imagerie RMN @5 10
C03 05  X  ENG  @0 Nuclear magnetic resonance imaging @5 10
C03 05  X  SPA  @0 Imaginería RMN @5 10
C03 06  X  FRE  @0 Fer @2 NC @5 11
C03 06  X  ENG  @0 Iron @2 NC @5 11
C03 06  X  SPA  @0 Hierro @2 NC @5 11
C03 07  X  FRE  @0 Ultrason @5 12
C03 07  X  ENG  @0 Ultrasound @5 12
C03 07  X  SPA  @0 Ultrasonido @5 12
C03 08  X  FRE  @0 Elément minéral @5 78
C03 08  X  ENG  @0 Inorganic element @5 78
C03 08  X  SPA  @0 Elemento inorgánico @5 78
C07 01  X  FRE  @0 Système nerveux central @5 37
C07 01  X  ENG  @0 Central nervous system @5 37
C07 01  X  SPA  @0 Sistema nervioso central @5 37
C07 02  X  FRE  @0 Hémopathie @5 38
C07 02  X  ENG  @0 Hemopathy @5 38
C07 02  X  SPA  @0 Hemopatía @5 38
C07 03  X  FRE  @0 Sidéropénie @5 39
C07 03  X  ENG  @0 Sideropenia @5 39
C07 03  X  SPA  @0 Sideropenia @5 39
C07 04  X  FRE  @0 Trouble neurologique @5 41
C07 04  X  ENG  @0 Neurological disorder @5 41
C07 04  X  SPA  @0 Trastorno neurológico @5 41
C07 05  X  FRE  @0 Trouble de la sensibilité @5 42
C07 05  X  ENG  @0 Sensitivity disorder @5 42
C07 05  X  SPA  @0 Trastorno sensibilidad @5 42
C07 06  X  FRE  @0 Maladie métabolique @5 43
C07 06  X  ENG  @0 Metabolic diseases @5 43
C07 06  X  SPA  @0 Metabolismo patología @5 43
N21       @1 224
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 08-0357271 INIST
ET : Multiregional Brain Iron Deficiency in Restless Legs Syndrome
AU : GODAU (Jana); KLOSE (Uwe); DI SANTO (Adriana); SCHWEITZER (Katherine); BERG (Daniela)
AF : Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen/Tuebingen/Allemagne (1 aut., 3 aut., 4 aut., 5 aut.); Section of Experimental MRI of the CNS, Department of Neuroradiology, University of Tuebingen/Tübingen/Allemagne (2 aut.)
DT : Publication en série; Courte communication, note brève; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 8; Pp. 1184-1187; Bibl. 16 ref.
LA : Anglais
EA : Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.
CC : 002B17; 002B17D
FD : Anémie ferriprive; Syndrome des jambes sans repos; Pathologie du système nerveux; Encéphale; Imagerie RMN; Fer; Ultrason; Elément minéral
FG : Système nerveux central; Hémopathie; Sidéropénie; Trouble neurologique; Trouble de la sensibilité; Maladie métabolique
ED : Iron deficiency anemia; Restless legs syndrome; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging; Iron; Ultrasound; Inorganic element
EG : Central nervous system; Hemopathy; Sideropenia; Neurological disorder; Sensitivity disorder; Metabolic diseases
SD : Anemia ferropénica; Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Imaginería RMN; Hierro; Ultrasonido; Elemento inorgánico
LO : INIST-20953.354000196042800160
ID : 08-0357271

Links to Exploration step

Pascal:08-0357271

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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<s0>Sideropenia</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="SPA">
<s0>Sideropenia</s0>
<s5>39</s5>
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<s0>Trouble neurologique</s0>
<s5>41</s5>
</fC07>
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<s0>Neurological disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Trastorno neurológico</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Trouble de la sensibilité</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Sensitivity disorder</s0>
<s5>42</s5>
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<fC07 i1="05" i2="X" l="SPA">
<s0>Trastorno sensibilidad</s0>
<s5>42</s5>
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<fC07 i1="06" i2="X" l="FRE">
<s0>Maladie métabolique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Metabolic diseases</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Metabolismo patología</s0>
<s5>43</s5>
</fC07>
<fN21>
<s1>224</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
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<s1>OTO</s1>
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<NO>PASCAL 08-0357271 INIST</NO>
<ET>Multiregional Brain Iron Deficiency in Restless Legs Syndrome</ET>
<AU>GODAU (Jana); KLOSE (Uwe); DI SANTO (Adriana); SCHWEITZER (Katherine); BERG (Daniela)</AU>
<AF>Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen/Tuebingen/Allemagne (1 aut., 3 aut., 4 aut., 5 aut.); Section of Experimental MRI of the CNS, Department of Neuroradiology, University of Tuebingen/Tübingen/Allemagne (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 8; Pp. 1184-1187; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9-7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = -0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status.</EA>
<CC>002B17; 002B17D</CC>
<FD>Anémie ferriprive; Syndrome des jambes sans repos; Pathologie du système nerveux; Encéphale; Imagerie RMN; Fer; Ultrason; Elément minéral</FD>
<FG>Système nerveux central; Hémopathie; Sidéropénie; Trouble neurologique; Trouble de la sensibilité; Maladie métabolique</FG>
<ED>Iron deficiency anemia; Restless legs syndrome; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging; Iron; Ultrasound; Inorganic element</ED>
<EG>Central nervous system; Hemopathy; Sideropenia; Neurological disorder; Sensitivity disorder; Metabolic diseases</EG>
<SD>Anemia ferropénica; Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Imaginería RMN; Hierro; Ultrasonido; Elemento inorgánico</SD>
<LO>INIST-20953.354000196042800160</LO>
<ID>08-0357271</ID>
</server>
</inist>
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