Autonomic dysfunction in different subtypes of multiple system atrophy
Identifieur interne : 003561 ( Main/Merge ); précédent : 003560; suivant : 003562Autonomic dysfunction in different subtypes of multiple system atrophy
Auteurs : Claudia Schmidt [Allemagne] ; Birgit Herting [Allemagne] ; Silke Prieur [Allemagne] ; Susann Junghanns [Allemagne] ; Katherine Schweitzer [Allemagne] ; Christoph Globas [Allemagne] ; Ludger Schöls [Allemagne] ; Heinz Reichmann [Allemagne] ; Daniela Berg [Allemagne] ; Tjalf Ziemssen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
English descriptors
- KwdEn :
- Aged, Autonomic Nervous System (physiopathology), Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (etiology), Female, Humans, MSA subtypes, Male, Middle Aged, Multiple System Atrophy (classification), Multiple System Atrophy (complications), autonomic dysfunction, autonomic nervous system, multiple system atrophy.
- MESH :
- classification : Multiple System Atrophy.
- complications : Multiple System Atrophy.
- diagnosis : Autonomic Nervous System Diseases.
- etiology : Autonomic Nervous System Diseases.
- physiopathology : Autonomic Nervous System.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA‐C) and the parkinsonian (MSA‐P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA‐C and 26 with MSA‐P in comparison with 27 age‐ and sex‐matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA‐P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA‐C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22187
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Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1766">1766</biblScope><biblScope unit="page" to="1772">1772</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">725C3392D497BA6250201A73255EA228FF648036</idno><idno type="DOI">10.1002/mds.22187</idno><idno type="ArticleID">MDS22187</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Autonomic Nervous System (physiopathology)</term><term>Autonomic Nervous System Diseases (diagnosis)</term><term>Autonomic Nervous System Diseases (etiology)</term><term>Female</term><term>Humans</term><term>MSA subtypes</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (classification)</term><term>Multiple System Atrophy (complications)</term><term>autonomic dysfunction</term><term>autonomic nervous system</term><term>multiple system atrophy</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Autonomic Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA‐C) and the parkinsonian (MSA‐P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA‐C and 26 with MSA‐P in comparison with 27 age‐ and sex‐matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA‐P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA‐C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes. © 2008 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.22187"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autonomic dysfunction in different subtypes of multiple system atrophy</title><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name></author><author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name></author><author><name sortKey="Prieur, Silke" sort="Prieur, Silke" uniqKey="Prieur S" first="Silke" last="Prieur">Silke Prieur</name></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:725C3392D497BA6250201A73255EA228FF648036</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22187</idno><idno type="url">https://api.istex.fr/document/725C3392D497BA6250201A73255EA228FF648036/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D73</idno><idno type="wicri:Area/Istex/Curation">000D73</idno><idno type="wicri:Area/Istex/Checkpoint">001539</idno><idno type="wicri:doubleKey">0885-3185:2008:Schmidt C:autonomic:dysfunction:in</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Autonomic dysfunction in different subtypes of multiple system atrophy</title><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Parkinson Research group, Department of Neurology, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Prieur, Silke" sort="Prieur, Silke" uniqKey="Prieur S" first="Silke" last="Prieur">Silke Prieur</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Parkinson Research group, Department of Neurology, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Disorders, Hertie Institute of Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Disorders, Hertie Institute of Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Disorders, Hertie Institute of Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Parkinson Research group, Department of Neurology, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Disorders, Hertie Institute of Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1766">1766</biblScope><biblScope unit="page" to="1772">1772</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">725C3392D497BA6250201A73255EA228FF648036</idno><idno type="DOI">10.1002/mds.22187</idno><idno type="ArticleID">MDS22187</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MSA subtypes</term><term>autonomic dysfunction</term><term>autonomic nervous system</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA‐C) and the parkinsonian (MSA‐P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA‐C and 26 with MSA‐P in comparison with 27 age‐ and sex‐matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA‐P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA‐C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes. © 2008 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autonomic dysfunction in different subtypes of multiple system atrophy.</title><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Autonomic and neuroendocrinological laboratory, University of Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name></author><author><name sortKey="Prieur, Silke" sort="Prieur, Silke" uniqKey="Prieur S" first="Silke" last="Prieur">Silke Prieur</name></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22187</idno><idno type="RBID">pubmed:18661564</idno><idno type="pmid">18661564</idno><idno type="wicri:Area/PubMed/Corpus">002135</idno><idno type="wicri:Area/PubMed/Curation">002135</idno><idno type="wicri:Area/PubMed/Checkpoint">002416</idno><idno type="wicri:Area/Ncbi/Merge">002228</idno><idno type="wicri:Area/Ncbi/Curation">002228</idno><idno type="wicri:Area/Ncbi/Checkpoint">002228</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Autonomic dysfunction in different subtypes of multiple system atrophy.</title><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Autonomic and neuroendocrinological laboratory, University of Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Autonomic and neuroendocrinological laboratory, University of Dresden</wicri:regionArea><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion><wicri:noRegion>University of Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name></author><author><name sortKey="Prieur, Silke" sort="Prieur, Silke" uniqKey="Prieur S" first="Silke" last="Prieur">Silke Prieur</name></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Autonomic Nervous System (physiopathology)</term><term>Autonomic Nervous System Diseases (diagnosis)</term><term>Autonomic Nervous System Diseases (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (classification)</term><term>Multiple System Atrophy (complications)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Autonomic Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA-C and 26 with MSA-P in comparison with 27 age- and sex-matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA-P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA-C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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