Autonomic dysfunction in different subtypes of multiple system atrophy.
Identifieur interne : 002228 ( Ncbi/Checkpoint ); précédent : 002227; suivant : 002229Autonomic dysfunction in different subtypes of multiple system atrophy.
Auteurs : Claudia Schmidt [Allemagne] ; Birgit Herting ; Silke Prieur ; Susann Junghanns ; Katherine Schweitzer ; Christoph Globas ; Ludger Schöls ; Heinz Reichmann ; Daniela Berg ; Tjalf ZiemssenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- classification : Multiple System Atrophy.
- complications : Multiple System Atrophy.
- diagnosis : Autonomic Nervous System Diseases.
- etiology : Autonomic Nervous System Diseases.
- physiopathology : Autonomic Nervous System.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA-C and 26 with MSA-P in comparison with 27 age- and sex-matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA-P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA-C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes.
DOI: 10.1002/mds.22187
PubMed: 18661564
Affiliations:
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<front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variant. However, till now, it is unknown whether autonomic dysfunction in these two entities differs regarding severity and profile. We compared the pattern of autonomic dysfunction in 12 patients with MSA-C and 26 with MSA-P in comparison with 27 age- and sex-matched healthy controls using a standard battery of autonomic function tests and a structured anamnesis of the autonomic nervous system. MSA-P patients complained significantly more often about the symptoms of autonomic dysfunctions than MSA-C patients, especially regarding vasomotor, secretomotor, and gastrointestinal subsystems. However, regarding cardiovascular, sudomotor pupil, urogenital, and sleep subsystems, there were no significant quantitative or qualitative differences as analyzed by autonomic anamnesis and testing. Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes.</div>
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<name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
<name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name>
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<name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
<name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name>
<name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
<name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name>
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