MovDisordV3, Main, Merge, bibRecord, 003511

Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study

Identifieur interne : 003511 ( Main/Merge ); précédent : 003510; suivant : 003512

Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study

Auteurs : David Devos [France] ; Kathy Dujardin [France] ; Isabelle Poirot [France] ; Caroline Moreau [France] ; Olivier Cottencin [France] ; Pierre Thomas [France] ; Alain Destée [France] ; Regis Bordet [France] ; Luc Defebvre [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-04-30.

RBID : ISTEX:06154D74D83A89BE5059BABDAB5AF0211C913E45

English descriptors

KwdEn :
- Aged, Antidepressive Agents (adverse effects), Antidepressive Agents (therapeutic use), Citalopram (adverse effects), Citalopram (therapeutic use), Depression (drug therapy), Depression (etiology), Desipramine (adverse effects), Desipramine (therapeutic use), Double-Blind Method, Female, Humans, Male, Middle Aged, Parkinson Disease (psychology), Parkinson's disease, Placebos, Prevalence, Psychiatric Status Rating Scales, antidepressant treatment, depression, norepinephrine, serotonin.
MESH :
- chemical , adverse effects : Antidepressive Agents, Citalopram, Desipramine.
- chemical , therapeutic use : Antidepressive Agents, Citalopram, Desipramine.
- drug therapy : Depression.
- etiology : Depression.
- psychology : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Prevalence, Psychiatric Status Rating Scales.

Abstract

Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short‐term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short‐term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double‐blind, randomized, placebo‐ controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short‐term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short‐term clinical advantage. © 2008 Movement Disorder Society

Url:

DOI: 10.1002/mds.21966

Links to Exploration step

ISTEX:06154D74D83A89BE5059BABDAB5AF0211C913E45

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:06154D74D83A89BE5059BABDAB5AF0211C913E45</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21966</idno>
<idno type="url">https://api.istex.fr/document/06154D74D83A89BE5059BABDAB5AF0211C913E45/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001072</idno>
<idno type="wicri:Area/Istex/Curation">001072</idno>
<idno type="wicri:Area/Istex/Checkpoint">001489</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Devos D:comparison:of:desipramine</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00336977</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00336977</idno>
<idno type="wicri:Area/Hal/Corpus">000016</idno>
<idno type="wicri:Area/Hal/Curation">000016</idno>
<idno type="wicri:Area/Hal/Checkpoint">000037</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Devos D:comparison:of:desipramine</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18311826</idno>
<idno type="wicri:Area/PubMed/Corpus">002298</idno>
<idno type="wicri:Area/PubMed/Curation">002298</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002372</idno>
<idno type="wicri:Area/Ncbi/Merge">002063</idno>
<idno type="wicri:Area/Ncbi/Curation">002063</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002063</idno>
<idno type="wicri:Area/Main/Merge">003511</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurophysiology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pharmacology, IFR 114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-04-30">2008-04-30</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="850">850</biblScope>
<biblScope unit="page" to="857">857</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">06154D74D83A89BE5059BABDAB5AF0211C913E45</idno>
<idno type="DOI">10.1002/mds.21966</idno>
<idno type="ArticleID">MDS21966</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antidepressive Agents (adverse effects)</term>
<term>Antidepressive Agents (therapeutic use)</term>
<term>Citalopram (adverse effects)</term>
<term>Citalopram (therapeutic use)</term>
<term>Depression (drug therapy)</term>
<term>Depression (etiology)</term>
<term>Desipramine (adverse effects)</term>
<term>Desipramine (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson's disease</term>
<term>Placebos</term>
<term>Prevalence</term>
<term>Psychiatric Status Rating Scales</term>
<term>antidepressant treatment</term>
<term>depression</term>
<term>norepinephrine</term>
<term>serotonin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antidepressive Agents</term>
<term>Citalopram</term>
<term>Desipramine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term>
<term>Citalopram</term>
<term>Desipramine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Placebos</term>
<term>Prevalence</term>
<term>Psychiatric Status Rating Scales</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short‐term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short‐term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double‐blind, randomized, placebo‐ controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short‐term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short‐term clinical advantage. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.21966"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1296" status="VALID"><orgName>Institut d'électronique, de microélectronique et de nanotechnologie</orgName>
<orgName type="acronym">IEMN</orgName>
<desc><address><addrLine>avenue Poincaré, Cité scientifique, BP 69, 59652 Villeneuve d'Ascq cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.iemn.univ-lille1.fr/</ref>
</desc>
<listRelation><relation active="#struct-300066" type="direct"></relation>
<relation active="#struct-300279" type="direct"></relation>
<relation active="#struct-300996" type="direct"></relation>
<relation name="UMR8520" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300066" type="direct"><org type="institution" xml:id="struct-300066" status="VALID"><orgName>Institut supérieur de l'électronique et du nunérique (ISEN)</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300279" type="direct"><org type="institution" xml:id="struct-300279" status="VALID"><orgName>Université de Valenciennes et du Hainaut-Cambresis</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300996" type="direct"><org type="institution" xml:id="struct-300996" status="INCOMING"><orgName>Université Lille 1 - Sciences et technologies</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8520" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-94723" status="VALID"><orgName>Noyaux gris centraux</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300070" type="direct"></relation>
<relation active="#struct-300996" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300996" type="direct"><org type="institution" xml:id="struct-300996" status="INCOMING"><orgName>Université Lille 1 - Sciences et technologies</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-11323" status="VALID"><orgName>Laboratoire de Neurosciences Fonctionnelles et Pathologies</orgName>
<orgName type="acronym">LNFP</orgName>
<desc><address><addrLine>Service EFV Hôpital Roger Salengro CHRU Lille 59037 Lille Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://LNFP.dr18.cnrs.fr</ref>
</desc>
<listRelation><relation active="#struct-300277" type="direct"></relation>
<relation name="UMR8160" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8160" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-11323" status="VALID"><orgName>Laboratoire de Neurosciences Fonctionnelles et Pathologies</orgName>
<orgName type="acronym">LNFP</orgName>
<desc><address><addrLine>Service EFV Hôpital Roger Salengro CHRU Lille 59037 Lille Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://LNFP.dr18.cnrs.fr</ref>
</desc>
<listRelation><relation active="#struct-300277" type="direct"></relation>
<relation name="UMR8160" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8160" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-58976" status="INCOMING"><orgName>Clinique Neurologique</orgName>
<desc><address><addrLine>Lille</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300070" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2775" status="VALID"><orgName>Institut de médecine predictive et de recherche thérapeutique</orgName>
<orgName type="acronym">IMPRT</orgName>
<desc><address><addrLine>Faculte de Medecine 1, Place de Verdun 59045 LILLE CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation name="IFR114" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300070" type="direct"></relation>
<relation active="#struct-300166" type="direct"></relation>
<relation active="#struct-300277" type="direct"></relation>
<relation active="#struct-301886" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="IFR114" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"><orgName>Institut Pasteur de Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301886" type="direct"><org type="institution" xml:id="struct-301886" status="VALID"><orgName>CRLCC Oscar Lambret</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00336977</idno>
<idno type="halId">hal-00336977</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00336977</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00336977</idno>
<idno type="doi">10.1002/mds.21966</idno>
<date when="2008-04-30">2008-04-30</date>
<idno type="wicri:Area/Hal/Corpus">000016</idno>
<idno type="wicri:Area/Hal/Curation">000016</idno>
<idno type="wicri:Area/Hal/Checkpoint">000037</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Devos D:comparison:of:desipramine</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1296" status="VALID"><orgName>Institut d'électronique, de microélectronique et de nanotechnologie</orgName>
<orgName type="acronym">IEMN</orgName>
<desc><address><addrLine>avenue Poincaré, Cité scientifique, BP 69, 59652 Villeneuve d'Ascq cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.iemn.univ-lille1.fr/</ref>
</desc>
<listRelation><relation active="#struct-300066" type="direct"></relation>
<relation active="#struct-300279" type="direct"></relation>
<relation active="#struct-300996" type="direct"></relation>
<relation name="UMR8520" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300066" type="direct"><org type="institution" xml:id="struct-300066" status="VALID"><orgName>Institut supérieur de l'électronique et du nunérique (ISEN)</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300279" type="direct"><org type="institution" xml:id="struct-300279" status="VALID"><orgName>Université de Valenciennes et du Hainaut-Cambresis</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300996" type="direct"><org type="institution" xml:id="struct-300996" status="INCOMING"><orgName>Université Lille 1 - Sciences et technologies</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8520" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-94723" status="VALID"><orgName>Noyaux gris centraux</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300070" type="direct"></relation>
<relation active="#struct-300996" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300996" type="direct"><org type="institution" xml:id="struct-300996" status="INCOMING"><orgName>Université Lille 1 - Sciences et technologies</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-11323" status="VALID"><orgName>Laboratoire de Neurosciences Fonctionnelles et Pathologies</orgName>
<orgName type="acronym">LNFP</orgName>
<desc><address><addrLine>Service EFV Hôpital Roger Salengro CHRU Lille 59037 Lille Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://LNFP.dr18.cnrs.fr</ref>
</desc>
<listRelation><relation active="#struct-300277" type="direct"></relation>
<relation name="UMR8160" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8160" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-11323" status="VALID"><orgName>Laboratoire de Neurosciences Fonctionnelles et Pathologies</orgName>
<orgName type="acronym">LNFP</orgName>
<desc><address><addrLine>Service EFV Hôpital Roger Salengro CHRU Lille 59037 Lille Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://LNFP.dr18.cnrs.fr</ref>
</desc>
<listRelation><relation active="#struct-300277" type="direct"></relation>
<relation name="UMR8160" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR8160" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-58976" status="INCOMING"><orgName>Clinique Neurologique</orgName>
<desc><address><addrLine>Lille</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300070" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2775" status="VALID"><orgName>Institut de médecine predictive et de recherche thérapeutique</orgName>
<orgName type="acronym">IMPRT</orgName>
<desc><address><addrLine>Faculte de Medecine 1, Place de Verdun 59045 LILLE CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation name="IFR114" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300070" type="direct"></relation>
<relation active="#struct-300166" type="direct"></relation>
<relation active="#struct-300277" type="direct"></relation>
<relation active="#struct-301886" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="IFR114" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300070" type="direct"><org type="institution" xml:id="struct-300070" status="VALID"><orgName>CHRU Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID"><orgName>Institut Pasteur de Lille</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300277" type="direct"><org type="institution" xml:id="struct-300277" status="VALID"><orgName>Université Lille II - Droit et santé</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301886" type="direct"><org type="institution" xml:id="struct-301886" status="VALID"><orgName>CRLCC Oscar Lambret</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
</author>
</analytic>
<idno type="DOI">10.1002/mds.21966</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2008-04-30</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short-term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double-blind, randomized, placebo- controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage.</div>
</front>
</TEI>
</HAL>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:06154D74D83A89BE5059BABDAB5AF0211C913E45</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21966</idno>
<idno type="url">https://api.istex.fr/document/06154D74D83A89BE5059BABDAB5AF0211C913E45/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001072</idno>
<idno type="wicri:Area/Istex/Curation">001072</idno>
<idno type="wicri:Area/Istex/Checkpoint">001489</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Devos D:comparison:of:desipramine</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurophysiology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pharmacology, IFR 114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-04-30">2008-04-30</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="850">850</biblScope>
<biblScope unit="page" to="857">857</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">06154D74D83A89BE5059BABDAB5AF0211C913E45</idno>
<idno type="DOI">10.1002/mds.21966</idno>
<idno type="ArticleID">MDS21966</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>antidepressant treatment</term>
<term>depression</term>
<term>norepinephrine</term>
<term>serotonin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short‐term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short‐term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double‐blind, randomized, placebo‐ controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short‐term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short‐term clinical advantage. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille, France. d-devos@chru-lille.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.21966</idno>
<idno type="RBID">pubmed:18311826</idno>
<idno type="pmid">18311826</idno>
<idno type="wicri:Area/PubMed/Corpus">002298</idno>
<idno type="wicri:Area/PubMed/Curation">002298</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002372</idno>
<idno type="wicri:Area/Ncbi/Merge">002063</idno>
<idno type="wicri:Area/Ncbi/Curation">002063</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002063</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study.</title>
<author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille, France. d-devos@chru-lille.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
<author><name sortKey="Poirot, Isabelle" sort="Poirot, Isabelle" uniqKey="Poirot I" first="Isabelle" last="Poirot">Isabelle Poirot</name>
</author>
<author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
</author>
<author><name sortKey="Cottencin, Olivier" sort="Cottencin, Olivier" uniqKey="Cottencin O" first="Olivier" last="Cottencin">Olivier Cottencin</name>
</author>
<author><name sortKey="Thomas, Pierre" sort="Thomas, Pierre" uniqKey="Thomas P" first="Pierre" last="Thomas">Pierre Thomas</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antidepressive Agents (adverse effects)</term>
<term>Antidepressive Agents (therapeutic use)</term>
<term>Citalopram (adverse effects)</term>
<term>Citalopram (therapeutic use)</term>
<term>Depression (drug therapy)</term>
<term>Depression (etiology)</term>
<term>Desipramine (adverse effects)</term>
<term>Desipramine (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (psychology)</term>
<term>Placebos</term>
<term>Prevalence</term>
<term>Psychiatric Status Rating Scales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antidepressive Agents</term>
<term>Citalopram</term>
<term>Desipramine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term>
<term>Citalopram</term>
<term>Desipramine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Placebos</term>
<term>Prevalence</term>
<term>Psychiatric Status Rating Scales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Depression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short-term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double-blind, randomized, placebo- controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003511 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003511 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:06154D74D83A89BE5059BABDAB5AF0211C913E45
   |texte=   Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study

Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.