Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features
Identifieur interne : 003124 ( Main/Merge ); précédent : 003123; suivant : 003125Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features
Auteurs : Lauren M. Myers [États-Unis] ; David R. Lynch [États-Unis] ; Jennifer M. Farmer [États-Unis] ; Lisa S. Friedman [États-Unis] ; John A. Lawson [États-Unis] ; Robert B. Wilson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-10-15.
English descriptors
- KwdEn :
- MESH :
- chemical , urine : Isoprostanes.
- urine : Friedreich Ataxia.
- Adult, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F2‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F2‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F2‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.
Url:
DOI: 10.1002/mds.22038
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Friedman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Children's Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lawson, John A" sort="Lawson, John A" uniqKey="Lawson J" first="John A." last="Lawson">John A. Lawson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Wilson, Robert B" sort="Wilson, Robert B" uniqKey="Wilson R" first="Robert B." last="Wilson">Robert B. Wilson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-10-15">2008-10-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1920">1920</biblScope><biblScope unit="page" to="1922">1922</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B9848DC061D01E81BC49CAFF39D2976CBC0FF5A3</idno><idno type="DOI">10.1002/mds.22038</idno><idno type="ArticleID">MDS22038</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Friedreich Ataxia (urine)</term><term>Humans</term><term>Isoprostanes (urine)</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term><term>ataxia</term><term>biomarker</term><term>neurogenetics</term><term>reactive oxygen species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Isoprostanes</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Friedreich Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F2‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F2‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F2‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.</div></front></TEI><double doi="10.1002/mds.22038"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features</title><author><name sortKey="Myers, Lauren M" sort="Myers, Lauren M" uniqKey="Myers L" first="Lauren M." last="Myers">Lauren M. Myers</name></author><author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R." last="Lynch">David R. Lynch</name></author><author><name sortKey="Farmer, Jennifer M" sort="Farmer, Jennifer M" uniqKey="Farmer J" first="Jennifer M." last="Farmer">Jennifer M. 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Wilson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B9848DC061D01E81BC49CAFF39D2976CBC0FF5A3</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22038</idno><idno type="url">https://api.istex.fr/document/B9848DC061D01E81BC49CAFF39D2976CBC0FF5A3/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001960</idno><idno type="wicri:Area/Istex/Curation">001960</idno><idno type="wicri:Area/Istex/Checkpoint">001102</idno><idno type="wicri:doubleKey">0885-3185:2008:Myers L:urinary:isoprostanes:in</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features</title><author><name sortKey="Myers, Lauren M" sort="Myers, Lauren M" uniqKey="Myers L" first="Lauren M." last="Myers">Lauren M. Myers</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Children's Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R." last="Lynch">David R. Lynch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Children's Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Farmer, Jennifer M" sort="Farmer, Jennifer M" uniqKey="Farmer J" first="Jennifer M." last="Farmer">Jennifer M. 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Friedman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Children's Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lawson, John A" sort="Lawson, John A" uniqKey="Lawson J" first="John A." last="Lawson">John A. Lawson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Wilson, Robert B" sort="Wilson, Robert B" uniqKey="Wilson R" first="Robert B." last="Wilson">Robert B. Wilson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-10-15">2008-10-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1920">1920</biblScope><biblScope unit="page" to="1922">1922</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B9848DC061D01E81BC49CAFF39D2976CBC0FF5A3</idno><idno type="DOI">10.1002/mds.22038</idno><idno type="ArticleID">MDS22038</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ataxia</term><term>biomarker</term><term>neurogenetics</term><term>reactive oxygen species</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F2‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F2‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F2‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Urinary isoprostanes in Friedreich ataxia: lack of correlation with disease features.</title><author><name sortKey="Myers, Lauren M" sort="Myers, Lauren M" uniqKey="Myers L" first="Lauren M" last="Myers">Lauren M. Myers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R" last="Lynch">David R. Lynch</name></author><author><name sortKey="Farmer, Jennifer M" sort="Farmer, Jennifer M" uniqKey="Farmer J" first="Jennifer M" last="Farmer">Jennifer M. Farmer</name></author><author><name sortKey="Friedman, Lisa S" sort="Friedman, Lisa S" uniqKey="Friedman L" first="Lisa S" last="Friedman">Lisa S. Friedman</name></author><author><name sortKey="Lawson, John A" sort="Lawson, John A" uniqKey="Lawson J" first="John A" last="Lawson">John A. Lawson</name></author><author><name sortKey="Wilson, Robert B" sort="Wilson, Robert B" uniqKey="Wilson R" first="Robert B" last="Wilson">Robert B. Wilson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22038</idno><idno type="RBID">pubmed:18671287</idno><idno type="pmid">18671287</idno><idno type="wicri:Area/PubMed/Corpus">002117</idno><idno type="wicri:Area/PubMed/Curation">002117</idno><idno type="wicri:Area/PubMed/Checkpoint">002003</idno><idno type="wicri:Area/Ncbi/Merge">002246</idno><idno type="wicri:Area/Ncbi/Curation">002246</idno><idno type="wicri:Area/Ncbi/Checkpoint">002246</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Urinary isoprostanes in Friedreich ataxia: lack of correlation with disease features.</title><author><name sortKey="Myers, Lauren M" sort="Myers, Lauren M" uniqKey="Myers L" first="Lauren M" last="Myers">Lauren M. Myers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R" last="Lynch">David R. Lynch</name></author><author><name sortKey="Farmer, Jennifer M" sort="Farmer, Jennifer M" uniqKey="Farmer J" first="Jennifer M" last="Farmer">Jennifer M. Farmer</name></author><author><name sortKey="Friedman, Lisa S" sort="Friedman, Lisa S" uniqKey="Friedman L" first="Lisa S" last="Friedman">Lisa S. Friedman</name></author><author><name sortKey="Lawson, John A" sort="Lawson, John A" uniqKey="Lawson J" first="John A" last="Lawson">John A. Lawson</name></author><author><name sortKey="Wilson, Robert B" sort="Wilson, Robert B" uniqKey="Wilson R" first="Robert B" last="Wilson">Robert B. Wilson</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Friedreich Ataxia (urine)</term><term>Humans</term><term>Isoprostanes (urine)</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Isoprostanes</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Friedreich Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F(2)-isoprostanes in patients with FA and healthy control subjects. Levels of urinary F(2)-isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F(2)-isoprostanes are not a useful biomarker in FA.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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