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Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

Identifieur interne : 002F54 ( Main/Merge ); précédent : 002F53; suivant : 002F55

Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

Auteurs : Greg T. Sutherland [Australie] ; Gerhard A. Siebert [Australie] ; Jeremy R. B. Newman [Australie] ; Peter A. Silburn [Australie] ; Richard S. Boyle [Australie] ; John D. O'Sullivan [Australie] ; George D. Mellick [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0136809

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Haplotype, Sporadique.

English descriptors

KwdEn :
- Haplotype, Nervous system diseases, Parkinson disease, Sporadic.

Abstract

Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.

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Le document en format XML

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<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Haplotype</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
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<tree><country name="Australie"><noRegion><name sortKey="Sutherland, Greg T" sort="Sutherland, Greg T" uniqKey="Sutherland G" first="Greg T." last="Sutherland">Greg T. Sutherland</name>
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<name sortKey="Boyle, Richard S" sort="Boyle, Richard S" uniqKey="Boyle R" first="Richard S." last="Boyle">Richard S. Boyle</name>
<name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<name sortKey="Newman, Jeremy R B" sort="Newman, Jeremy R B" uniqKey="Newman J" first="Jeremy R. B." last="Newman">Jeremy R. B. Newman</name>
<name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
<name sortKey="Siebert, Gerhard A" sort="Siebert, Gerhard A" uniqKey="Siebert G" first="Gerhard A." last="Siebert">Gerhard A. Siebert</name>
<name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
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</country>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri