Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease
Identifieur interne : 000F51 ( PascalFrancis/Corpus ); précédent : 000F50; suivant : 000F52Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease
Auteurs : Greg T. Sutherland ; Gerhard A. Siebert ; Jeremy R. B. Newman ; Peter A. Silburn ; Richard S. Boyle ; John D. O'Sullivan ; George D. MellickSource :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 09-0136809 INIST |
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ET : | Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease |
AU : | SUTHERLAND (Greg T.); SIEBERT (Gerhard A.); NEWMAN (Jeremy R. B.); SILBURN (Peter A.); BOYLE (Richard S.); O'SULLIVAN (John D.); MELLICK (George D.) |
AF : | Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University/Brisbane, Queensland/Australie (1 aut., 2 aut., 3 aut., 4 aut., 7 aut.); UQ Centre for Clinical Research, School of Medicine, University of Queensland/Brisbane, Queensland/Australie (4 aut.); Department of Neurology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (5 aut., 7 aut.); Department of Neurology, Royal Brisbane and Women's Hospital/Brisbane, Queensland/Australie (6 aut., 7 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 3; Pp. 449-452; Bibl. 21 ref. |
LA : | Anglais |
EA : | Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Haplotype; Sporadique |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Haplotype; Sporadic |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Haplotipo; Esporádico |
LO : | INIST-20953.354000186999840220 |
ID : | 09-0136809 |
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Pascal:09-0136809Le document en format XML
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<front><div type="abstract" xml:lang="en">Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.</div>
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<server><NO>PASCAL 09-0136809 INIST</NO>
<ET>Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease</ET>
<AU>SUTHERLAND (Greg T.); SIEBERT (Gerhard A.); NEWMAN (Jeremy R. B.); SILBURN (Peter A.); BOYLE (Richard S.); O'SULLIVAN (John D.); MELLICK (George D.)</AU>
<AF>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University/Brisbane, Queensland/Australie (1 aut., 2 aut., 3 aut., 4 aut., 7 aut.); UQ Centre for Clinical Research, School of Medicine, University of Queensland/Brisbane, Queensland/Australie (4 aut.); Department of Neurology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (5 aut., 7 aut.); Department of Neurology, Royal Brisbane and Women's Hospital/Brisbane, Queensland/Australie (6 aut., 7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 3; Pp. 449-452; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Haplotype; Sporadique</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Haplotype; Sporadic</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Haplotipo; Esporádico</SD>
<LO>INIST-20953.354000186999840220</LO>
<ID>09-0136809</ID>
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