Long-Term Effects of Pallidal or Subthalamic Deep Brain Stimulation on Quality of Life in Parkinson's Disease
Identifieur interne : 002F18 ( Main/Merge ); précédent : 002F17; suivant : 002F19Long-Term Effects of Pallidal or Subthalamic Deep Brain Stimulation on Quality of Life in Parkinson's Disease
Auteurs : Jens Volkmann [Allemagne] ; Alberto Albanese [Italie] ; Jaime Kulisevsky [Espagne] ; Aana-Lena Tornqvist [Suède] ; Jean-Luc Houeto [France] ; Bernard Pidoux [France] ; Anne-Marie Bonnet [France] ; Alexandre Mendes [France] ; Alim-Louis Benabid [France] ; Valerie Fraix [France] ; Nadege Van Blercom [France] ; JING XIE [France] ; José Obeso [Espagne] ; Maria Cruz Rodriguez-Oroz [Espagne] ; Jurge Guridi [Espagne] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Alexandre A. Gironell [Espagne] ; Juan Molet [Espagne] ; Benta Pascual-Sedano [Espagne] ; Stig Rehncrona [Suède] ; Elena Moro [Canada] ; Anthony C. Lang [Canada] ; Andres M. Lozano [Canada] ; Anna Rita Bentivoglio [Italie] ; Massimo Scerrati [Italie] ; Maria Fiorella Contarino [Pays-Bas] ; Luigi Romito [Italie] ; Marc Janssens [Pays-Bas] ; Yves Agid [France]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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- Pascal (Inist)
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Abstract
We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi-DBS and n = 45/49 patients with STN-DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off-period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN-DBS and M, SI after GPi-DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN-DBS and GPi-DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health-related wellbeing over time.
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Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Tornqvist, Aana Lena" sort="Tornqvist, Aana Lena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation wicri:level="1"><inist:fA14 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aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Rodriguez Oroz, Maria" sort="Cruz Rodriguez Oroz, Maria" uniqKey="Cruz Rodriguez Oroz M" first="Maria" last="Cruz Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Neurologische Klinik, Heinrich-Heine-Universität Düsseldorf</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universität Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurologische Klinik, Universität zu Köln</s1><s2>Köln</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName><orgName type="university">Université de Cologne</orgName></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Sedano, Benta" sort="Pascual Sedano, Benta" uniqKey="Pascual Sedano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>4 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Movement Disorders Center, Toronto Western Hospital, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Movement Disorders Center, Toronto Western Hospital, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Division of Neurosurgery, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>24 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rita Bentivoglio, Anna" sort="Rita Bentivoglio, Anna" uniqKey="Rita Bentivoglio A" first="Anna" last="Rita Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neuroscience, Catholic University</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fiorella Contarino, Maria" sort="Fiorella Contarino, Maria" uniqKey="Fiorella Contarino M" first="Maria" last="Fiorella Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academisch Medisch Centrum</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Bakken Research Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bakken Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0301986</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0301986 INIST</idno><idno type="RBID">Pascal:09-0301986</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E52</idno><idno type="wicri:Area/PascalFrancis/Curation">001E67</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E21</idno><idno type="wicri:doubleKey">0885-3185:2009:Volkmann J:long:term:effects</idno><idno type="wicri:Area/Main/Merge">002F18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-Term Effects of Pallidal or Subthalamic Deep Brain Stimulation on Quality of Life in Parkinson's Disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Neurologische Klinik der Christian-Albrechts-Universität</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Tornqvist, Aana Lena" sort="Tornqvist, Aana Lena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>4 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology or Neurosurgery, University Hospital of Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Rodriguez Oroz, Maria" sort="Cruz Rodriguez Oroz, Maria" uniqKey="Cruz Rodriguez Oroz M" first="Maria" last="Cruz Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Neurologische Klinik, Heinrich-Heine-Universität Düsseldorf</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine-Universität Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurologische Klinik, Universität zu Köln</s1><s2>Köln</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName><orgName type="university">Université de Cologne</orgName></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Sedano, Benta" sort="Pascual Sedano, Benta" uniqKey="Pascual Sedano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de Sant Pau and CIBERNED</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>4 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Movement Disorders Center, Toronto Western Hospital, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Movement Disorders Center, Toronto Western Hospital, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Division of Neurosurgery, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>24 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rita Bentivoglio, Anna" sort="Rita Bentivoglio, Anna" uniqKey="Rita Bentivoglio A" first="Anna" last="Rita Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neuroscience, Catholic University</s1><s2>Rome</s2><s3>ITA</s3><sZ>25 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fiorella Contarino, Maria" sort="Fiorella Contarino, Maria" uniqKey="Fiorella Contarino M" first="Maria" last="Fiorella Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academisch Medisch Centrum</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>26 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Bakken Research Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bakken Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Long term</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Quality of life</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Long terme</term><term>Qualité de vie</term><term>Noyau sousthalamique</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi-DBS and n = 45/49 patients with STN-DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off-period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN-DBS and M, SI after GPi-DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN-DBS and GPi-DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health-related wellbeing over time.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Suède</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>District de Cologne</li><li>Hollande-Septentrionale</li><li>Latium</li><li>Lombardie</li><li>Ontario</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li><li>Schleswig-Holstein</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Cologne</li><li>Grenoble</li><li>Kiel</li><li>Milan</li><li>Paris</li><li>Rome</li><li>Toronto</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li><li>Hôpital de la Salpêtrière</li><li>Université de Cologne</li><li>Université de Toronto</li></orgName></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></region><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></region><name sortKey="Rita Bentivoglio, Anna" sort="Rita Bentivoglio, Anna" uniqKey="Rita Bentivoglio A" first="Anna" last="Rita Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></region><name sortKey="Cruz Rodriguez Oroz, Maria" sort="Cruz Rodriguez Oroz, Maria" uniqKey="Cruz Rodriguez Oroz M" first="Maria" last="Cruz Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><name sortKey="Pascual Sedano, Benta" sort="Pascual Sedano, Benta" uniqKey="Pascual Sedano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name></country><country name="Suède"><noRegion><name sortKey="Tornqvist, Aana Lena" sort="Tornqvist, Aana Lena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name></noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></country><country name="France"><noRegion><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></noRegion><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name></country><country name="Canada"><region name="Ontario"><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></region><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Fiorella Contarino, Maria" sort="Fiorella Contarino, Maria" uniqKey="Fiorella Contarino M" first="Maria" last="Fiorella Contarino">Maria Fiorella Contarino</name></region><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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