MovDisordV3, Main, Merge, bibRecord, 002C83

Bowel movement frequency in late‐life and substantia nigra neuron density at death

Identifieur interne : 002C83 ( Main/Merge ); précédent : 002C82; suivant : 002C84

Bowel movement frequency in late‐life and substantia nigra neuron density at death

Auteurs : Helen Petrovitch [États-Unis] ; Robert D. Abbott [États-Unis, Japon] ; G. Webster Ross [États-Unis] ; James Nelson [États-Unis] ; Kamal H. Masaki [États-Unis] ; Caroline M. Tanner [États-Unis] ; Lenore J. Launer [États-Unis] ; Lon R. White [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-02-15.

RBID : ISTEX:A787CEEBA3ED38B1F489FC646FA5F72765C42C64

English descriptors

KwdEn :
- Aged, Cell Count, Constipation (epidemiology), Constipation (pathology), Diagnosis, Humans, Lewy Bodies (pathology), Lewy body, Locus Coeruleus (pathology), Male, Neurons (pathology), Parkinson Disease (epidemiology), Parkinson Disease (pathology), Parkinson's disease, Prevalence, Substantia Nigra (pathology), constipation, neuron density, substantia nigra.
MESH :
- epidemiology : Constipation, Parkinson Disease.
- pathology : Constipation, Lewy Bodies, Locus Coeruleus, Neurons, Parkinson Disease, Substantia Nigra.
- Aged, Cell Count, Diagnosis, Humans, Male, Prevalence.

Abstract

Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late‐life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu‐Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm2) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB. © 2008 Movement Disorder Society

Url:

DOI: 10.1002/mds.22360

Links to Exploration step

ISTEX:A787CEEBA3ED38B1F489FC646FA5F72765C42C64

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cell Count</term>
<term>Constipation (epidemiology)</term>
<term>Constipation (pathology)</term>
<term>Diagnosis</term>
<term>Humans</term>
<term>Lewy Bodies (pathology)</term>
<term>Lewy body</term>
<term>Locus Coeruleus (pathology)</term>
<term>Male</term>
<term>Neurons (pathology)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson's disease</term>
<term>Prevalence</term>
<term>Substantia Nigra (pathology)</term>
<term>constipation</term>
<term>neuron density</term>
<term>substantia nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Constipation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Constipation</term>
<term>Lewy Bodies</term>
<term>Locus Coeruleus</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cell Count</term>
<term>Diagnosis</term>
<term>Humans</term>
<term>Male</term>
<term>Prevalence</term>
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<front><div type="abstract" xml:lang="en">Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late‐life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu‐Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm2) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB. © 2008 Movement Disorder Society</div>
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<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Health Research Institute, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Honolulu‐Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Health Research Institute, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Honolulu‐Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Health Research Institute, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Honolulu‐Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson's Institute, Sunnyvale, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Health Research Institute, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Honolulu‐Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-02-15">2009-02-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="371">371</biblScope>
<biblScope unit="page" to="376">376</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A787CEEBA3ED38B1F489FC646FA5F72765C42C64</idno>
<idno type="DOI">10.1002/mds.22360</idno>
<idno type="ArticleID">MDS22360</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body</term>
<term>Parkinson's disease</term>
<term>constipation</term>
<term>neuron density</term>
<term>substantia nigra</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late‐life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu‐Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm2) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</title>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Health Science, Shiga University of Medical Science, Otsu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Health Science, Shiga University of Medical Science, Otsu</wicri:regionArea>
<wicri:noRegion>Otsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Parkinson’s Institute, Sunnyvale, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A10">National Institute on Aging, National Institutes of Health, Bethesda, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19006191</idno>
<idno type="pmc">3272050</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272050</idno>
<idno type="RBID">PMC:3272050</idno>
<idno type="doi">10.1002/mds.22360</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000154</idno>
<idno type="wicri:Area/Pmc/Curation">000154</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000418</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001F30</idno>
<idno type="wicri:Area/PubMed/Curation">001F30</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F25</idno>
<idno type="wicri:Area/Ncbi/Merge">002434</idno>
<idno type="wicri:Area/Ncbi/Curation">002434</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002434</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Petrovitch H:bowel:movement:frequency</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</title>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Health Science, Shiga University of Medical Science, Otsu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Health Science, Shiga University of Medical Science, Otsu</wicri:regionArea>
<wicri:noRegion>Otsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Parkinson’s Institute, Sunnyvale, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A10">National Institute on Aging, National Institutes of Health, Bethesda, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cell Count</term>
<term>Constipation (epidemiology)</term>
<term>Constipation (pathology)</term>
<term>Diagnosis</term>
<term>Humans</term>
<term>Lewy Bodies (pathology)</term>
<term>Locus Coeruleus (pathology)</term>
<term>Male</term>
<term>Neurons (pathology)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Prevalence</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Constipation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Constipation</term>
<term>Lewy Bodies</term>
<term>Locus Coeruleus</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cell Count</term>
<term>Diagnosis</term>
<term>Humans</term>
<term>Male</term>
<term>Prevalence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Constipation is associated with future risk of Parkinson’s disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and post mortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In non-smokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (p<0.001) for dorsomedial; 15.3, 16.4, 10.2 (p<0.03) for ventromedial; and 18.6, 18.3, 10.9 (p=0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</p>
</div>
</front>
</TEI>
</PMC>
</double>
</record>

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Movement Disorders (revue)

Bowel movement frequency in late‐life and substantia nigra neuron density at death

Bowel movement frequency in late‐life and substantia nigra neuron density at death

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	Movement Disorders (revue)
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