Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death
Identifieur interne : 000418 ( Pmc/Checkpoint ); précédent : 000417; suivant : 000419Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death
Auteurs : Helen Petrovitch [États-Unis] ; Robert D. Abbott [États-Unis, Japon] ; G. Webster Ross [États-Unis] ; James Nelson [États-Unis] ; Kamal H. Masaki [États-Unis] ; Caroline M. Tanner [États-Unis] ; Lenore J. Launer [États-Unis] ; Lon R. White [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009.
Abstract
Constipation is associated with future risk of Parkinson’s disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and post mortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In non-smokers, neuron densities (counts/mm2) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (p<0.001) for dorsomedial; 15.3, 16.4, 10.2 (p<0.03) for ventromedial; and 18.6, 18.3, 10.9 (p=0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.
Url:
DOI: 10.1002/mds.22360
PubMed: 19006191
PubMed Central: 3272050
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</title>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
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<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
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<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
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<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
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<placeName><region type="state">Hawaï</region>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A3">Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville</wicri:cityArea>
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<affiliation wicri:level="1"><nlm:aff id="A4">Department of Health Science, Shiga University of Medical Science, Otsu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Health Science, Shiga University of Medical Science, Otsu</wicri:regionArea>
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<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
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<author><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
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<placeName><region type="state">Hawaï</region>
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<author><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
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<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
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<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
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<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Parkinson’s Institute, Sunnyvale, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A10">National Institute on Aging, National Institutes of Health, Bethesda, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pacific Health Research Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
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<wicri:cityArea>Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
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<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">Constipation is associated with future risk of Parkinson’s disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and post mortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In non-smokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (p<0.001) for dorsomedial; 15.3, 16.4, 10.2 (p<0.03) for ventromedial; and 18.6, 18.3, 10.9 (p=0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title-group><journal-title>Movement Disorders</journal-title>
</journal-title-group>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19006191</article-id>
<article-id pub-id-type="pmc">3272050</article-id>
<article-id pub-id-type="doi">10.1002/mds.22360</article-id>
<article-id pub-id-type="manuscript">NIHMS100661</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Petrovitch</surname>
<given-names>Helen</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abbott</surname>
<given-names>Robert D.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ross</surname>
<given-names>G. Webster</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nelson</surname>
<given-names>James</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Masaki</surname>
<given-names>Kamal H.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tanner</surname>
<given-names>Caroline M.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Launer</surname>
<given-names>Lenore J.</given-names>
</name>
<degrees>Ph.D</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>White</surname>
<given-names>Lon R.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Pacific Health Research Institute, Honolulu, Hawaii</aff>
<aff id="A2"><label>2</label>
The Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, Hawaii</aff>
<aff id="A3"><label>3</label>
Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia</aff>
<aff id="A4"><label>4</label>
Department of Health Science, Shiga University of Medical Science, Otsu, Japan</aff>
<aff id="A5"><label>5</label>
Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</aff>
<aff id="A6"><label>6</label>
Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</aff>
<aff id="A7"><label>7</label>
Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</aff>
<aff id="A8"><label>8</label>
Department of Pathology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</aff>
<aff id="A9"><label>9</label>
Parkinson’s Institute, Sunnyvale, California</aff>
<aff id="A10"><label>10</label>
National Institute on Aging, National Institutes of Health, Bethesda, MD</aff>
<author-notes><corresp id="cor1">Address for correspondence: Helen Petrovitch, MD, 846 South Hotel Street, Suite 307, Honolulu, Hawaii, 96813, USA, Telephone: 808 564-5420, Fax: 808-524-4315, <email>hpetrovitch@phrihawaii.org</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>26</day>
<month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>2</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>2</month>
<year>2012</year>
</pub-date>
<volume>24</volume>
<issue>3</issue>
<fpage>371</fpage>
<lpage>376</lpage>
<abstract><p id="P1">Constipation is associated with future risk of Parkinson’s disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and post mortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In non-smokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (p<0.001) for dorsomedial; 15.3, 16.4, 10.2 (p<0.03) for ventromedial; and 18.6, 18.3, 10.9 (p=0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</p>
</abstract>
<kwd-group><kwd>Parkinson’s disease</kwd>
<kwd>constipation</kwd>
<kwd>Lewy body</kwd>
<kwd>substantia nigra</kwd>
<kwd>neuron density</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source>
<award-id>U01 AG019349-07 || AG</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source>
<award-id>U01 AG017155-08 || AG</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source>
<award-id>R01 NS041265-09 || NS</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Japon</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Hawaï</li>
<li>Maryland</li>
<li>Virginie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Hawaï"><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
</region>
<name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H." last="Masaki">Kamal H. Masaki</name>
<name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
</country>
<country name="Japon"><noRegion><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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