Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Identifieur interne : 002566 ( Main/Merge ); précédent : 002565; suivant : 002567Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Auteurs : Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Pierre Pollak [France] ; Yves Agid [France] ; Stig Rehncrona [Suède] ; Jens Volkmann [Allemagne] ; Jaime Kulisevsky [Espagne] ; Jose A. Obeso [Espagne] ; Alberto Albanese [Italie] ; Marwan I. Hariz [Royaume-Uni, Suède] ; Niall P. Quinn [Canada] ; Jans D. Speelman [Pays-Bas] ; Alim-Louis Benabid [France] ; Valerie Fraix [France] ; Alexandre Mendes [France] ; Marie-Laure Welter [France] ; Jean-Luc Houeto [France] ; Philippe Cornu [France] ; Didier Dormont [France] ; Annalena L. Tornqvist [Suède] ; Ron Ekberg [Suède] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Lars Wojtecki [Allemagne] ; Andres Gironell [Espagne] ; Maria C. Rodriguez-Oroz [Espagne] ; Jorge Guridi [Espagne] ; Anna R. Bentivoglio [Italie] ; Maria F. Contarino [Italie, Pays-Bas] ; Luigi Romito [Italie] ; Massimo Scerrati [Italie] ; Marc Janssens [Pays-Bas] ; Anthony E. Lang [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
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<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
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<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name>
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<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
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<author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
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<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
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<author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
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<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
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<author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1>
<s2>London</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1>
<s2>Umeå</s2>
<s3>SWE</s3>
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<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
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<author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
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<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
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</placeName>
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</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
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<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
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<author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
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<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1>
<s2>Poitiers</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
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</inist:fA14>
<country>Suède</country>
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</affiliation>
</author>
<author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, University Hospital</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
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<country>Allemagne</country>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>University Hospital</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Ancona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Bakken Research Center</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Bakken Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0233216</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0233216 INIST</idno>
<idno type="RBID">Pascal:10-0233216</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000B40</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002179</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000979</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Moro E:long:term:results</idno>
<idno type="wicri:Area/Main/Merge">002566</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</title>
<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1>
<s2>Umeå</s2>
<s3>SWE</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
</affiliation>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1>
<s2>Poitiers</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, University Hospital</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>University Hospital</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Heinrich-Heine-Universitat Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto Nazionale Neurologico C. Besta and Università Cattolica</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Ancona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Bakken Research Center</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Bakken Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Long term</term>
<term>Multicenter study</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Long terme</term>
<term>Etude multicentrique</term>
<term>Noyau sousthalamique</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Catalogne</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Latium</li>
<li>Rhône-Alpes</li>
<li>Schleswig-Holstein</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Barcelone</li>
<li>Grenoble</li>
<li>Kiel</li>
<li>Londres</li>
<li>Paris</li>
<li>Poitiers</li>
<li>Rome</li>
</settlement>
<orgName><li>Centre hospitalier universitaire Grenoble Alpes</li>
<li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
</noRegion>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
</country>
<country name="France"><noRegion><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
</noRegion>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name>
<name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name>
<name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
<name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
<name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name>
<name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
</country>
<country name="Suède"><noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name>
</noRegion>
<name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name>
<name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name>
<name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name>
</country>
<country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
</region>
<name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
</region>
<name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name>
<name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name>
</country>
<country name="Italie"><noRegion><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
</noRegion>
<name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name>
<name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name>
<name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name>
<name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
<name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name>
</region>
<name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name>
<name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name>
</country>
</tree>
</affiliations>
</record>
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