The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease
Identifieur interne : 002373 ( Main/Merge ); précédent : 002372; suivant : 002374The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease
Auteurs : HYE YOUNG SUNG [Corée du Sud] ; Joong-Seok Kim [Corée du Sud] ; Kwang-Soo Lee [Corée du Sud] ; Yeong-In Kim [Corée du Sud] ; In-Uk Song [Corée du Sud] ; Sung-Woo Chung [Corée du Sud] ; Dong-Won Yang [Corée du Sud] ; YU KYUNG CHO [Corée du Sud] ; JAE MYUNG PARK [Corée du Sud] ; IN SEOK LEE [Corée du Sud] ; SANG WOO KIM [Corée du Sud] ; In-Sik Chung [Corée du Sud] ; Myung-Gyu Choi [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease</title><author><name sortKey="Hye Young Sung" sort="Hye Young Sung" uniqKey="Hye Young Sung" last="Hye Young Sung">HYE YOUNG SUNG</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Health Promotion, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement 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type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sung Woo" sort="Chung, Sung Woo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yang, Dong Won" sort="Yang, Dong Won" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yu Kyung Cho" sort="Yu Kyung Cho" uniqKey="Yu Kyung Cho" last="Yu Kyung Cho">YU KYUNG CHO</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Jae Myung Park" sort="Jae Myung Park" uniqKey="Jae Myung Park" last="Jae Myung Park">JAE MYUNG PARK</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 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Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0491595</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0491595 INIST</idno><idno type="RBID">Pascal:10-0491595</idno><idno type="wicri:Area/PascalFrancis/Corpus">000841</idno><idno type="wicri:Area/PascalFrancis/Curation">002478</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000786</idno><idno type="wicri:doubleKey">0885-3185:2010:Hye Young Sung:the:prevalence:and</idno><idno type="wicri:Area/Main/Merge">002373</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease</title><author><name sortKey="Hye Young Sung" sort="Hye Young Sung" uniqKey="Hye Young Sung" last="Hye Young Sung">HYE YOUNG SUNG</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Health Promotion, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Joong Seok" sort="Kim, Joong Seok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Kwang Soo" sort="Lee, Kwang Soo" uniqKey="Lee K" first="Kwang-Soo" last="Lee">Kwang-Soo Lee</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Yeong In" sort="Kim, Yeong In" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Song, In Uk" sort="Song, In Uk" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sung Woo" sort="Chung, Sung Woo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yang, Dong Won" sort="Yang, Dong Won" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Yu Kyung Cho" sort="Yu Kyung Cho" uniqKey="Yu Kyung Cho" last="Yu Kyung Cho">YU KYUNG CHO</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Jae Myung Park" sort="Jae Myung Park" uniqKey="Jae Myung Park" last="Jae Myung Park">JAE MYUNG PARK</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="In Seok Lee" sort="In Seok Lee" uniqKey="In Seok Lee" last="In Seok Lee">IN SEOK LEE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Sang Woo Kim" sort="Sang Woo Kim" uniqKey="Sang Woo Kim" last="Sang Woo Kim">SANG WOO KIM</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, In Sik" sort="Chung, In Sik" uniqKey="Chung I" first="In-Sik" last="Chung">In-Sik Chung</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Choi, Myung Gyu" sort="Choi, Myung Gyu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dysphagia</term><term>Early stage</term><term>Esophagus</term><term>Human</term><term>Manometry</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Prevalence</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Dysphagie</term><term>Pathologie du système nerveux</term><term>Prévalence</term><term>Homme</term><term>Stade précoce</term><term>Oesophage</term><term>Manométrie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Hye Young Sung" sort="Hye Young Sung" uniqKey="Hye Young Sung" last="Hye Young Sung">HYE YOUNG SUNG</name></noRegion><name sortKey="Choi, Myung Gyu" sort="Choi, Myung Gyu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name><name sortKey="Chung, In Sik" sort="Chung, In Sik" uniqKey="Chung I" first="In-Sik" last="Chung">In-Sik Chung</name><name sortKey="Chung, Sung Woo" sort="Chung, Sung Woo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name><name sortKey="Hye Young Sung" sort="Hye Young Sung" uniqKey="Hye Young Sung" last="Hye Young Sung">HYE YOUNG SUNG</name><name sortKey="In Seok Lee" sort="In Seok Lee" uniqKey="In Seok Lee" last="In Seok Lee">IN SEOK LEE</name><name sortKey="Jae Myung Park" sort="Jae Myung Park" uniqKey="Jae Myung Park" last="Jae Myung Park">JAE MYUNG PARK</name><name sortKey="Kim, Joong Seok" sort="Kim, Joong Seok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name><name sortKey="Kim, Yeong In" sort="Kim, Yeong In" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name><name sortKey="Lee, Kwang Soo" sort="Lee, Kwang Soo" uniqKey="Lee K" first="Kwang-Soo" last="Lee">Kwang-Soo Lee</name><name sortKey="Sang Woo Kim" sort="Sang Woo Kim" uniqKey="Sang Woo Kim" last="Sang Woo Kim">SANG WOO KIM</name><name sortKey="Song, In Uk" sort="Song, In Uk" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name><name sortKey="Yang, Dong Won" sort="Yang, Dong Won" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name><name sortKey="Yu Kyung Cho" sort="Yu Kyung Cho" uniqKey="Yu Kyung Cho" last="Yu Kyung Cho">YU KYUNG CHO</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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