MovDisordV3, PascalFrancis, Curation, bibRecord, 002478

The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease

Identifieur interne : 002478 ( PascalFrancis/Curation ); précédent : 002477; suivant : 002479

The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease

Auteurs : HYE YOUNG SUNG [Corée du Sud] ; Joong-Seok Kim [Corée du Sud] ; Kwang-Soo Lee [Corée du Sud] ; Yeong-In Kim [Corée du Sud] ; In-Uk Song [Corée du Sud] ; Sung-Woo Chung [Corée du Sud] ; Dong-Won Yang [Corée du Sud] ; YU KYUNG CHO [Corée du Sud] ; JAE MYUNG PARK [Corée du Sud] ; IN SEOK LEE [Corée du Sud] ; SANG WOO KIM [Corée du Sud] ; In-Sik Chung [Corée du Sud] ; Myung-Gyu Choi [Corée du Sud]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0491595

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Dysphagie, Pathologie du système nerveux, Prévalence, Homme, Stade précoce, Oesophage, Manométrie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Dysphagia, Early stage, Esophagus, Human, Manometry, Nervous system diseases, Parkinson disease, Prevalence.

Abstract

Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease</title>
<author><name sortKey="Hye Young Sung" sort="Hye Young Sung" uniqKey="Hye Young Sung" last="Hye Young Sung">HYE YOUNG SUNG</name>
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<term>Parkinson disease</term>
<term>Prevalence</term>
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<front><div type="abstract" xml:lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease

The Prevalence and Patterns of Pharyngoesophageal Dysmotility in Patients with Early Stage Parkinson's Disease

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