Juvenile levodopa‐responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment
Identifieur interne : 002052 ( Main/Merge ); précédent : 002051; suivant : 002053Juvenile levodopa‐responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment
Auteurs : Alberto J. Espay [États-Unis] ; Dominic C. Paviour [Royaume-Uni] ; John D. O'Sullivan [Australie] ; Robert E. Schmidt [États-Unis] ; Fredy J. Revilla [États-Unis] ; Leo Verhagen Metman [États-Unis] ; David Williams [États-Unis, Royaume-Uni, Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
- Adolescent, Brain (surgery), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Cognition Disorders (therapy), Deep Brain Stimulation, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (physiopathology), Female, Humans, Intranuclear Inclusion Bodies, Levodopa (adverse effects), Levodopa (therapeutic use), Magnetic Resonance Imaging, Neurodegenerative Diseases (complications), Neurodegenerative Diseases (diagnosis), Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (therapy), Parkinsonian Disorders (etiology), Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (therapy), Parkinsonism pathology, Young Adult, juvenile Parkinsonism, neuronal intranuclear inclusion disease.
- MESH :
- chemical , adverse effects : Levodopa.
- complications : Neurodegenerative Diseases.
- diagnosis : Dyskinesia, Drug-Induced, Neurodegenerative Diseases.
- etiology : Cognition Disorders, Parkinsonian Disorders.
- physiopathology : Cognition Disorders, Dyskinesia, Drug-Induced, Neurodegenerative Diseases, Parkinsonian Disorders.
- surgery : Brain.
- chemical , therapeutic use : Levodopa.
- therapy : Cognition Disorders, Neurodegenerative Diseases, Parkinsonian Disorders.
- Adolescent, Deep Brain Stimulation, Female, Humans, Intranuclear Inclusion Bodies, Magnetic Resonance Imaging, Young Adult.
Abstract
A 13‐year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug‐induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23194
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ISTEX:78422B2EF2963DA60256D44D2E9C07CD1308B47DLe document en format XML
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<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (therapy)</term>
<term>Deep Brain Stimulation</term>
<term>Dyskinesia, Drug-Induced (diagnosis)</term>
<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
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<term>Neurodegenerative Diseases (diagnosis)</term>
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<term>Parkinsonian Disorders (physiopathology)</term>
<term>Parkinsonian Disorders (therapy)</term>
<term>Parkinsonism pathology</term>
<term>Young Adult</term>
<term>juvenile Parkinsonism</term>
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<front><div type="abstract" xml:lang="en">A 13‐year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug‐induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2010 Movement Disorder Society</div>
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<idno type="ISSN">0885-3185</idno>
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<idno type="istex">78422B2EF2963DA60256D44D2E9C07CD1308B47D</idno>
<idno type="DOI">10.1002/mds.23194</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinsonism pathology</term>
<term>juvenile Parkinsonism</term>
<term>neuronal intranuclear inclusion disease</term>
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<front><div type="abstract" xml:lang="en">A 13‐year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug‐induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2010 Movement Disorder Society</div>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment.</title>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio, USA. espayaj@ucmail.uc.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
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<author><name sortKey="Paviour, Dominic C" sort="Paviour, Dominic C" uniqKey="Paviour D" first="Dominic C" last="Paviour">Dominic C. Paviour</name>
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<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name>
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<author><name sortKey="Schmidt, Robert E" sort="Schmidt, Robert E" uniqKey="Schmidt R" first="Robert E" last="Schmidt">Robert E. Schmidt</name>
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<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
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<author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name>
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<date when="2010">2010</date>
<idno type="doi">10.1002/mds.23194</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment.</title>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio, USA. espayaj@ucmail.uc.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
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<author><name sortKey="Paviour, Dominic C" sort="Paviour, Dominic C" uniqKey="Paviour D" first="Dominic C" last="Paviour">Dominic C. Paviour</name>
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<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name>
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<author><name sortKey="Schmidt, Robert E" sort="Schmidt, Robert E" uniqKey="Schmidt R" first="Robert E" last="Schmidt">Robert E. Schmidt</name>
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<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
</author>
<author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
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<term>Brain (surgery)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (therapy)</term>
<term>Deep Brain Stimulation</term>
<term>Dyskinesia, Drug-Induced (diagnosis)</term>
<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Intranuclear Inclusion Bodies</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Magnetic Resonance Imaging</term>
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<term>Neurodegenerative Diseases (diagnosis)</term>
<term>Neurodegenerative Diseases (physiopathology)</term>
<term>Neurodegenerative Diseases (therapy)</term>
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<term>Parkinsonian Disorders (physiopathology)</term>
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<term>Neurodegenerative Diseases</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term>
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<term>Deep Brain Stimulation</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</div>
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